{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:50:01Z","timestamp":1792191001778,"version":"4.4.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,3,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Virtually no reports on the effects of exercise in patients with a small abdominal aortic aneurysm (\n              <jats:styled-content style=\"fixed-case\">AAA<\/jats:styled-content>\n              ) exist.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We conducted a retrospective cohort study on 1515 patients with a small\n              <jats:styled-content style=\"fixed-case\">AAA<\/jats:styled-content>\n              before surgery at 2 high\u2010volume hospitals in Tokyo, Japan, from April 2004 to September 2015. A carefully modified cardiac rehabilitation program without excessive blood pressure elevation during exercise was prescribed to 50 patients with an\n              <jats:styled-content style=\"fixed-case\">AAA<\/jats:styled-content>\n              . Using propensity score matching, mortality and clinical outcomes, including\n              <jats:styled-content style=\"fixed-case\">AAA<\/jats:styled-content>\n              expansion rate, were compared between 2 groups: rehabilitation group and nonrehabilitation group. The background characteristics of the rehabilitation group (n=49) and the nonrehabilitation group (n=163) were almost identical. The risk for\n              <jats:styled-content style=\"fixed-case\">AAA<\/jats:styled-content>\n              repair was much lower in the rehabilitation group after matching (before matching: hazard ratio, 0.43; 95% confidence interval, 0.25\u20130.72;\n              <jats:italic>P<\/jats:italic>\n              =0.001; and after matching: hazard ratio, 0.19; 95% confidence interval, 0.07\u20130.50;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001).\n              <jats:styled-content style=\"fixed-case\">AAA<\/jats:styled-content>\n              expansion rate was slower in the rehabilitation group (before matching: rehabilitation versus nonrehabilitation group, 2.3\u00b13.7\u00a0versus 3.8\u00b13.4\u00a0mm\/y [\n              <jats:italic>P<\/jats:italic>\n              =0.008]; after matching: rehabilitation versus nonrehabilitation group, 2.1\u00b13.0 versus 4.5\u00b14.0\u00a0mm\/y [\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001]). Elevation of blood pressure during exercise was positively correlated with\n              <jats:styled-content style=\"fixed-case\">AAA<\/jats:styled-content>\n              expansion rate after the rehabilitation program (\n              <jats:italic>r<\/jats:italic>\n              =0.569,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Cardiac rehabilitation protects against the expansion of small\n              <jats:styled-content style=\"fixed-case\">AAA<\/jats:styled-content>\n              s and mitigates the risk associated with\n              <jats:styled-content style=\"fixed-case\">AAA<\/jats:styled-content>\n              repair, possibly because of the decreased elevation of blood pressure during exercise.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Clinical Trial Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/upload.umin.ac.jp\">upload.umin.ac.jp<\/jats:ext-link>\n              . Unique identifier:\n              <jats:styled-content style=\"fixed-case\">UMIN<\/jats:styled-content>\n              000028237.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.117.007959","type":"journal-article","created":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T01:10:24Z","timestamp":1519780224000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":32,"title":["Cardiac Rehabilitation Protects Against the Expansion of Abdominal Aortic Aneurysm"],"prefix":"10.1161","volume":"7","author":[{"given":"Atsuko","family":"Nakayama","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, The University of Tokyo, Japan"},{"name":"Sakakibara Heart Institute, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The University of Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Nagayama","sequence":"additional","affiliation":[{"name":"Sakakibara Heart Institute, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuyuki","family":"Hoshina","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery, Graduate School of Medicine, The University of Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukari","family":"Uemura","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Central Coordinating Unit, Clinical Research Support Center, The University of Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitonobu","family":"Tomoike","sequence":"additional","affiliation":[{"name":"Sakakibara Heart Institute, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Issei","family":"Komuro","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The University of Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/M13-1844"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1401430"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.817619"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2013.12.011"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000075572.40158.77"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.17.1764"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-66-0094"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aep205"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2013.09.001"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3182a088b8"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.892224"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001547"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1191\/0269215502cr524oa"},{"key":"e_1_3_3_15_2","first-page":"1249","article-title":"Guidelines for diagnosis and treatment of aortic aneurysm and aortic dissection (JCS 1988)","volume":"64","author":"JCS Joint Working Group","year":"2000","unstructured":"JCS Joint Working Group . 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