{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T04:09:55Z","timestamp":1793333395853,"version":"4.5.0"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,3,20]]},"abstract":"\n Background<\/jats:title>\n \n Percutaneous mitral valve edge\u2010to\u2010edge repair (\n pMVR<\/jats:styled-content>\n ) with a MitraClip is beneficial for the clinical symptoms of patients irrespective of the ejection fraction (\n EF<\/jats:styled-content>\n ). Nevertheless, the consequences on hemodynamics are poorly understood. Therefore, we used data from noninvasive pressure\u2010volume loops to investigate the left ventricular (LV) remodeling of patients after\n pMVR<\/jats:styled-content>\n dependent on their baseline EF.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n In 130 patients with successful\n pMVR<\/jats:styled-content>\n , the end\u2010diastolic pressure\u2010volume relationship (EDPVR) and end\u2010systolic pressure\u2010volume relationship were estimated noninvasively from echocardiographic data. We compared\n EDPVR<\/jats:styled-content>\n and end\u2010systolic pressure\u2010volume relationship at discharge and follow\u2010up between patients with a reduced\n EF<\/jats:styled-content>\n (<40%) and patients with a mid\u2010ranged or preserved\n EF<\/jats:styled-content>\n (\u226540%). Reduced\n EF<\/jats:styled-content>\n was present in 71 patients (54%). Mean follow\u2010up duration was 277\u00b1117 days. We observed a significant reduction in degree of mitral regurgitation and an improvement in functional status at follow\u2010up irrespective of baseline\n EF<\/jats:styled-content>\n . In patients with a mid\u2010ranged or preserved\n EF<\/jats:styled-content>\n , the\n EDPVR<\/jats:styled-content>\n and end\u2010systolic pressure\u2010volume relationship were shifted leftwards, suggesting an improvement in\n LV<\/jats:styled-content>\n function. In contrast, in patients with a reduced\n EF<\/jats:styled-content>\n ,\n EDPVR<\/jats:styled-content>\n and end\u2010systolic pressure\u2010volume relationship remained stable, although comparison with the baseline data indicates a rightward shift of the\n EDPVR<\/jats:styled-content>\n . This indicates that there is no improvement in\n LV<\/jats:styled-content>\n function after\n pMVR<\/jats:styled-content>\n in patients with reduced EF.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The pMVR is associated with improved clinical symptoms in all patient subgroups. However, it leads to different hemodynamic responses. In patients with mid\u2010ranged or preserved\n EF<\/jats:styled-content>\n , we found reverse remodeling with reduced\n LV<\/jats:styled-content>\n dilatation and increased contractility. In contrast, in patients with reduced\n EF<\/jats:styled-content>\n , we observed no reverse remodeling and no improvement in\n LV<\/jats:styled-content>\n function.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.117.007963","type":"journal-article","created":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T09:15:14Z","timestamp":1521105314000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Distinct Hemodynamic Changes After Interventional Mitral Valve Edge\u2010to\u2010Edge Repair in Different Phenotypes of Heart Failure: An Integrated Hemodynamic Analysis"],"prefix":"10.1161","volume":"7","author":[{"given":"Benedikt","family":"Schrage","sequence":"first","affiliation":[{"name":"Department of General and Interventional Cardiology, University Heart Center Hamburg Eppendorf, Hamburg, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner site Hamburg\/Kiel\/L\u00fcbeck, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Kalbacher","sequence":"additional","affiliation":[{"name":"Department of General and Interventional Cardiology, University Heart Center Hamburg Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schwarzl","sequence":"additional","affiliation":[{"name":"Department of General and Interventional Cardiology, University Heart Center Hamburg Eppendorf, Hamburg, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner site Hamburg\/Kiel\/L\u00fcbeck, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"R\u00fcbsamen","sequence":"additional","affiliation":[{"name":"Department of General and Interventional Cardiology, University Heart Center Hamburg Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Waldeyer","sequence":"additional","affiliation":[{"name":"Department of General and Interventional Cardiology, University Heart Center Hamburg Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Moritz","family":"Becher","sequence":"additional","affiliation":[{"name":"Department of General and Interventional Cardiology, University Heart Center Hamburg Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eike","family":"Tigges","sequence":"additional","affiliation":[{"name":"Department of General and Interventional Cardiology, University Heart Center Hamburg Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Burkhoff","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation and Columbia University, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Blankenberg","sequence":"additional","affiliation":[{"name":"Department of General and Interventional Cardiology, University Heart Center Hamburg Eppendorf, Hamburg, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner site Hamburg\/Kiel\/L\u00fcbeck, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Lubos","sequence":"additional","affiliation":[{"name":"Department of General and Interventional Cardiology, University Heart Center Hamburg Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Sch\u00e4fer","sequence":"additional","affiliation":[{"name":"Department of General and Interventional Cardiology, University Heart Center Hamburg Eppendorf, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Westermann","sequence":"additional","affiliation":[{"name":"Department of General and Interventional Cardiology, University Heart Center Hamburg Eppendorf, Hamburg, Germany"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner site Hamburg\/Kiel\/L\u00fcbeck, Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezs455"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(99)00175-7"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm001"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.10.018"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.06.1166"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.11.241"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hft046"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jeq031"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01240.2005"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01651-5"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.102.15.1788"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00138.2005"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2009.176248"},{"key":"e_1_3_2_15_2","volume-title":"Applied Longitudinal Data Analysis for Epidemiology: A Practical Guide","author":"Twisk JWR","year":"2003","unstructured":"Twisk JWR. Applied Longitudinal Data Analysis for Epidemiology: A Practical Guide. Cambridge, England: Cambridge University Press; 2003."},{"key":"e_1_3_2_16_2","volume-title":"Fixed Effects Regression Methods for Longitudinal Data: Using SAS","author":"Allison PD","year":"2005","unstructured":"Allison PD. Fixed Effects Regression Methods for Longitudinal Data: Using SAS. Cary, North Carolina, USA: SAS Institute; 2005."},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.135061"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw120"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.12.062"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.07.047"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1512913"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2016.06.036"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.117.007963","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:08:08Z","timestamp":1715598488000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.117.007963"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,20]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,3,20]]}},"alternative-id":["10.1161\/JAHA.117.007963"],"URL":"https:\/\/doi.org\/10.1161\/jaha.117.007963","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,20]]},"assertion":[{"value":"2017-10-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e007963"}}