{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:12:38Z","timestamp":1791821558931,"version":"4.3.4"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,4,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Subgroup analyses from randomized trials indicate that the time interval between the neurologic index event and carotid artery stenting is associated with periprocedural stroke and death rates in patients with symptomatic carotid stenosis. The aim of this article is to analyze whether this observation holds true under routine conditions in Germany.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Secondary data analysis was done on 4717 elective carotid artery stenting procedures that were performed for symptomatic carotid stenosis. The patient cohort was divided into 4 groups according to the time interval between the index event and intervention (group I 0\u20102,\n              <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\n              3\u20107,\n              <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\n              8\u201014, and\n              <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\n              15\u2010180\u00a0days). Primary outcome was any in\u2010hospital stroke or death. For risk\u2010adjusted analyses, a multilevel multivariable regression model was used. The in\u2010hospital stroke or death rate was 3.7% in total and 6.0%, 4.4%, 2.4%, and 3.0% in groups I,\n              <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\n              ,\n              <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\n              , and\n              <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\n              , respectively. Adjusted analysis showed a decreased risk for any stroke or death in group\n              <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\n              , a decreased risk for any major stroke or death in groups\n              <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\n              and\n              <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>\n              , and a decreased risk for any death in groups\n              <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\n              and\n              <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\n              compared to the reference group I.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">A short time interval between the neurologic index event and carotid artery stenting of up to 7\u00a0days is associated with an increased risk for stroke or death under routine conditions in Germany. Although results cannot prove causal relationships,\u00a0carotid artery stenting may be accompanied by an increased risk of stroke or death during the early period after the index event.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.117.007983","type":"journal-article","created":{"date-parts":[[2018,3,27]],"date-time":"2018-03-27T15:20:11Z","timestamp":1522164011000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":25,"title":["Risk of Stroke or Death Is Associated With the Timing of Carotid Artery Stenting for Symptomatic Carotid Stenosis: A Secondary Data Analysis of the German Statutory Quality Assurance Database"],"prefix":"10.1161","volume":"7","author":[{"given":"Pavlos","family":"Tsantilas","sequence":"first","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Kuehnl","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kallmayer","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Knappich","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofie","family":"Schmid","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorben","family":"Breitkreuz","sequence":"additional","affiliation":[{"name":"aQua\u2014Institute for Applied Quality Improvement and Research in Health GmbH, G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans\u2010Henning","family":"Eckstein","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","first-page":"845","article-title":"Stroke risk in the early period after carotid related symptoms: a systematic review","volume":"56","author":"Tsantilas P","year":"2015","unstructured":"Tsantilas P, Kuhnl A, Kallmayer M, Knappich C, Schmid S, Kuetchou A, Zimmermann A, Eckstein HH. 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