{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T15:49:40Z","timestamp":1770220180252,"version":"3.49.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,3,20]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In atrial fibrillation (\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              ), a more extensively fibrotic left atrium (\n              <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>\n              ) provides a substrate for arrhythmias and increases risk of relapse following ablation. Fibrocytes are bone marrow\u2013derived circulating mesenchymal progenitors that have been identified in the atrium of patients with AF who have valvular diseases. The present study investigates the associations between circulating fibrocytes and\n              <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>\n              fibrosis or the prevalence of recurrence after ablation in patients with persistent\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              .\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We measured the proportion, differentiation, and migration of circulating fibrocytes from patients with persistent\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              (n=40), those with paroxysmal\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              (n=30), and sinus rhythm controls (n=30).\n              <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>\n              low\u2010voltage (fibrosis) area was identified by an electroanatomic mapping system, and patients were followed up for 1\u00a0year after ablation. The relationship between circulating fibrocyte percentage and\n              <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>\n              low\u2010voltage area or recurrence was assessed by multivariate regression analysis. Circulating fibrocyte percentage positively associated with\n              <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>\n              low\u2010voltage area in the persistent\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              group, and circulating fibrocyte (\u22654.05%) was a significant predictor of 1\u2010year recurrence after ablation. Cultured fibrocytes exhibited enhanced potential of differentiation in the persistent\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              group (67.58\u00b11.54%) versus the paroxysmal\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              group (56.67\u00b11.52%) and sinus rhythm controls (48.43\u00b11.79%). Furthermore, expression of fibroblast activation markers and cell migratory ability were also elevated in differentiated fibrocytes from patients with persistent\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              . Transforming growth factor \u03b21 and stromal cell\u2013derived factor 1 were elevated in the plasma of patients with persistent AF and were shown to promote fibrocyte differentiation and migration, respectively.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In patients with persistent\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              , increased circulating fibrocytes served as a marker of\n              <jats:styled-content style=\"fixed-case\">LA<\/jats:styled-content>\n              fibrosis and recurrence.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.117.008083","type":"journal-article","created":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T00:10:30Z","timestamp":1520986230000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":33,"title":["Elevated Circulating Fibrocytes Is a Marker of Left Atrial Fibrosis and Recurrence of Persistent Atrial Fibrillation"],"prefix":"10.1161","volume":"7","author":[{"given":"Yang","family":"Liu","sequence":"first","affiliation":[{"name":"Institute of Cardiovascular Diseases, The First Affiliated Hospital of Dalian Medical University, Dalian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Hui","family":"Niu","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Diseases, The First Affiliated Hospital of Dalian Medical University, Dalian, China"},{"name":"Department of Cardiology, The First Affiliated Hospital of Dalian Medical University, Dalian, 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Health, School of Public Health, Dalian Medical University, Dalian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Diseases, The First Affiliated Hospital of Dalian Medical University, Dalian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohong","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianjun","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Dalian Medical University, Dalian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan\u2010Zong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of 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