{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T02:27:26Z","timestamp":1786760846173,"version":"build-2736575974"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,6,19]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The treatment of mycotic abdominal aortic aneurysm requires surgery and antimicrobial therapy. Since prosthetic reconstructions carry a considerable risk of reinfection, biological grafts are noteworthy alternatives. The current study evaluated the durability, infection resistance, and midterm outcome of biological grafts in treatment of mycotic abdominal aortic aneurysm.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">All patients treated with biological graft in 6 countries between 2006 and 2016 were included. Primary outcome measures were 30\u2010 and 90\u2010day survival, treatment\u2010related mortality, and reinfection rate. Secondary outcome measures were overall mortality and graft patency. Fifty\u2010six patients (46 males) with median age of 69\u00a0years (range 35\u201385) were included. Sixteen patients were immunocompromised (29%), 24 (43%) had concomitant infection, and 12 (21%) presented with rupture. Bacterial culture was isolated from 43 (77%). In\u2010situ aortic reconstruction was performed using autologous femoral veins in 30 patients (54%), xenopericardial tube\u2010grafts in 12 (21%), cryopreserved arterial\/venous allografts in 9 (16%), and fresh arterial allografts in 5 (9%) patients. During a median follow\u2010up of 26\u00a0months (range 3\u00a0weeks\u2013172\u00a0months) there were no reinfections and only 3 patients (5%) required assistance with graft patency. Thirty\u2010day survival was 95% (n=53) and 90\u2010day survival was 91% (n=51). Treatment\u2010related mortality was 9% (n=5). Kaplan\u2013Meier estimation of survival at 1\u00a0year was 83% (95% confidence interval, 73%\u201394%) and at 5\u00a0years was 71% (52%\u201389%).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Mycotic abdominal aortic aneurysm repair with biological grafts is a durable option for patients fit for surgery presenting an excellent infection resistance and good overall survival.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.117.008104","type":"journal-article","created":{"date-parts":[[2018,6,9]],"date-time":"2018-06-09T09:15:11Z","timestamp":1528535711000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":58,"title":["Open Repair of Mycotic Abdominal Aortic Aneurysms With Biological Grafts: An International Multicenter Study"],"prefix":"10.1161","volume":"7","author":[{"given":"Ivika","family":"Heinola","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"S\u00f6relius","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences Section\u00a0of Vascular Surgery Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R.","family":"Wyss","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Inselspital, Bern University Hospital University of Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaj","family":"Eldrup","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicla","family":"Settembre","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Nancy University Hospital Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Setacci","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical and Neurosciences University of Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Mani","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences Section\u00a0of Vascular Surgery Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilkka","family":"Kantonen","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarit","family":"Venermo","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery University of Helsinki and Helsinki University Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.1262.467"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2008.08.004"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1067\/mva.2001.118084"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-011-1104-9"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2004.02.024"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2014.04.023"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1583\/13-4222MR.1"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0741-5214(84)90040-5"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1983.01390050059011"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.009481"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.024021"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2007.07.025"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2009.08.004"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2011.07.050"},{"key":"e_1_3_1_16_2","first-page":"514","article-title":"Primary infected aortic aneurysm: clinical presentation, pathogen, and outcome","volume":"30","author":"Lin CH","year":"2014","unstructured":"Lin CH, Hsu RB. 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