{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T03:43:32Z","timestamp":1774323812417,"version":"3.50.1"},"reference-count":53,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,3,20]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Prenatal hypoxia is suggested to be associated with increased risks of hypertension in offspring. This study tested whether prenatal hypoxia resulted in salt\u2010sensitive offspring and its related mechanisms of vascular ion channel remodeling.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Pregnant rats were housed in a normoxic (21% O\n              <jats:sub>2<\/jats:sub>\n              ) or hypoxic (10.5% O\n              <jats:sub>2<\/jats:sub>\n              ) chamber from gestation days 5 to 21. A subset of male offspring received a high\u2010salt diet (8% NaCl) from 4 to 12\u00a0weeks after birth. Blood pressure was significantly increased only in the salt\u2010loading offspring exposed to prenatal hypoxia, not in the offspring that received regular diets and in control offspring provided with high\u2010salt diets. In mesenteric artery myocytes from the salt\u2010loading offspring with prenatal hypoxia, depolarized resting membrane potential was associated with decreased density of L\u2010type voltage\u2010gated Ca\n              <jats:sup>2+<\/jats:sup>\n              (Cav1.2) and voltage\u2010gated K\n              <jats:sup>+<\/jats:sup>\n              channel currents and decreased calcium sensitive to the large\u2010conductance Ca\n              <jats:sup>2+<\/jats:sup>\n              \u2010activated K\n              <jats:sup>+<\/jats:sup>\n              channels. Protein expression of the L\u2010type voltage\u2010gated Ca\n              <jats:sup>2+<\/jats:sup>\n              \u03b11C subunit, large\u2010conductance calcium\u2010activated K\n              <jats:sup>+<\/jats:sup>\n              channel (\u03b21, not \u03b1 subunits), and voltage\u2010gated K\n              <jats:sup>+<\/jats:sup>\n              channel (\n              <jats:styled-content style=\"fixed-case\">\n                K\n                <jats:sub>V<\/jats:sub>\n              <\/jats:styled-content>\n              2.1, not\n              <jats:styled-content style=\"fixed-case\">\n                K\n                <jats:sub>V<\/jats:sub>\n              <\/jats:styled-content>\n              1.5 subunits) was also decreased in the arteries of salt\u2010loading offspring with prenatal hypoxia.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">The results demonstrated that chronic prenatal hypoxia may program salt\u2010sensitive hypertension in male offspring, providing new information of ion channel remodeling in hypertensive myocytes. This information paves the way for early prevention and treatments of salt\u2010induced hypertension related to developmental problems in fetal origins.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.117.008148","type":"journal-article","created":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T09:15:14Z","timestamp":1521105314000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Downregulation of L\u2010Type Voltage\u2010Gated Ca\n            <sup>2+<\/sup>\n            , Voltage\u2010Gated K\n            <sup>+<\/sup>\n            , and Large\u2010Conductance Ca\n            <sup>2+<\/sup>\n            \u2010Activated K\n            <sup>+<\/sup>\n            Channels in Vascular Myocytes From Salt\u2010Loading Offspring Rats Exposed to Prenatal Hypoxia"],"prefix":"10.1161","volume":"7","author":[{"given":"Bailin","family":"Liu","sequence":"first","affiliation":[{"name":"Institute for Fetology, First Hospital of Soochow University, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruixiu","family":"Shi","sequence":"additional","affiliation":[{"name":"Institute for Fetology, First Hospital of Soochow University, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Li","sequence":"additional","affiliation":[{"name":"Institute for Fetology, First Hospital of Soochow University, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanping","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute for Fetology, First Hospital of Soochow University, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueqin","family":"Feng","sequence":"additional","affiliation":[{"name":"Institute for Fetology, First Hospital of Soochow University, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueyi","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute for Fetology, First Hospital of Soochow University, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaorong","family":"Fan","sequence":"additional","affiliation":[{"name":"Institute for Fetology, First Hospital of Soochow University, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute for Fetology, First Hospital of Soochow University, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenna","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute for Fetology, First Hospital of Soochow University, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqi","family":"Tang","sequence":"additional","affiliation":[{"name":"Institute for Fetology, First Hospital of Soochow University, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuwen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute for Fetology, First Hospital of Soochow University, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[{"name":"Institute for Fetology, First Hospital of Soochow University, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiyuan","family":"Lu","sequence":"additional","affiliation":[{"name":"Institute for Fetology, First Hospital of Soochow University, Suzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhice","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute for Fetology, First Hospital of Soochow University, Suzhou, China"},{"name":"Center for Perinatal Biology, Loma Linda University, Loma Linda, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","first-page":"520","article-title":"Causes de l'hypertension arterielle","volume":"1","author":"Ambard L","year":"1904","unstructured":"Ambard L, Beaujard E. 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