{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:39:14Z","timestamp":1791639554569,"version":"4.3.4"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,3,20]]},"abstract":"\n Background<\/jats:title>\n \n Recent studies demonstrated a strong association between atrial fibrillation (\n AF<\/jats:styled-content>\n ) and epicardial fat around the left atrium (\n LA<\/jats:styled-content>\n ). We sought to assess whether epicardial fat volume around the\n LA<\/jats:styled-content>\n is associated with\n AF<\/jats:styled-content>\n , and to determine the additive value of\n LA<\/jats:styled-content>\n \u2010epicardial fat measurements to\n LA<\/jats:styled-content>\n structural remodeling for identifying patients with\n AF<\/jats:styled-content>\n using 3\u2010dimensional multi\u2010echo Dixon fat\u2013water separated cardiovascular magnetic resonance.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n A total of 105 subjects were studied: 53 patients with a history of\n AF<\/jats:styled-content>\n and 52 age\u2010matched patients with other cardiovascular diseases but no history of\n AF<\/jats:styled-content>\n . The 3\u2010dimensional multi\u2010echo Dixon fat\u2010water separated sequence was performed for\n LA<\/jats:styled-content>\n \u2010epicardial fat measurements.\n AF<\/jats:styled-content>\n patients had significantly greater\n LA<\/jats:styled-content>\n \u2010epicardial fat (28.9\u00b112.3 and 14.2\u00b17.3\u00a0mL for\n AF<\/jats:styled-content>\n and non\u2010\n AF<\/jats:styled-content>\n , respectively;\n P<\/jats:italic>\n <0.001) and\n LA<\/jats:styled-content>\n volume (110.8\u00b138.2 and 89.7\u00b130.3\u00a0mL for\n AF<\/jats:styled-content>\n and non\u2010\n AF<\/jats:styled-content>\n , respectively;\n P<\/jats:italic>\n =0.002).\n LA<\/jats:styled-content>\n \u2010epicardial fat adjusted for\n LA<\/jats:styled-content>\n volume was still higher in patients with\n AF<\/jats:styled-content>\n compared with those without\n AF<\/jats:styled-content>\n (\n P<\/jats:italic>\n <0.001).\n LA<\/jats:styled-content>\n \u2010epicardial fat and hypertension were independently associated with the risk of\n AF<\/jats:styled-content>\n (odds ratio, 1.17; 95% confidence interval, 1.10%\u20131.25%,\n P<\/jats:italic>\n <0.001, and odds ratio, 3.29; 95% confidence interval, 1.17%\u20139.27%,\n P<\/jats:italic>\n =0.03, respectively). In multivariable logistic regression analysis adjusted for body surface area,\n LA<\/jats:styled-content>\n \u2010epicardial fat remained significant and an increase per mL was associated with a 42% increase in the odds of\n AF<\/jats:styled-content>\n presence (odds ratio, 1.42; 95% confidence interval, 1.23%\u20131.62%,\n P<\/jats:italic>\n <0.001). Combined assessment of\n LA<\/jats:styled-content>\n \u2010epicardial fat and\n LA<\/jats:styled-content>\n volume provided greater discriminatory performance for detecting\n AF<\/jats:styled-content>\n than\n LA<\/jats:styled-content>\n volume alone (c\u2010statistic=0.88 and 0.74, respectively, DeLong test;\n P<\/jats:italic>\n <0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Cardiovascular magnetic resonance 3\u2010dimensional Dixon\u2010based\n LA<\/jats:styled-content>\n \u2010epicardial fat volume is significantly increased in\n AF<\/jats:styled-content>\n patients.\n LA<\/jats:styled-content>\n \u2010epicardial fat measured by 3\u2010dimensional Dixon provides greater performance for detecting\n AF<\/jats:styled-content>\n beyond\n LA<\/jats:styled-content>\n structural remodeling.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.117.008232","type":"journal-article","created":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T09:30:18Z","timestamp":1521797418000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":69,"title":["Left Atrial Epicardial Fat Volume Is Associated With Atrial Fibrillation: A Prospective Cardiovascular Magnetic Resonance 3D Dixon Study"],"prefix":"10.1161","volume":"7","author":[{"given":"Shiro","family":"Nakamori","sequence":"first","affiliation":[{"name":"Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Nezafat","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long H.","family":"Ngo","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren J.","family":"Manning","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA"},{"name":"Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Nezafat","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.10.946"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)01107-4"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.008201"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.03.054"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.02.048"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2007.00626.x"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.09.026"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.055"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.828970"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.109.912055"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.110.957241"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.116.004378"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.03.071"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2005.02054.x"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.743062"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv625"},{"key":"e_1_3_4_18_2","first-page":"421","volume-title":"Magnetic Resonance Imaging: Physical Principles and Sequence Design","author":"Haacke EM","year":"1999","unstructured":"Haacke EM, Brown RW, Thompson MR, Venkatesan R. 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