{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:40:30Z","timestamp":1792647630841,"version":"4.5.0"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,5,15]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Depression in patients with coronary artery disease (\n              <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>\n              ) is associated with increased cardiovascular morbidity. Given the proinflammatory actions of phospholipids, aberrant phospholipid metabolism may be an etiological mechanism linking\n              <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>\n              and depression. Our primary objective was to identify a phospholipid biomarker panel that characterizes\n              <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>\n              patients with significant depressive symptoms from those without.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We performed a targeted lipidomic analysis on\n              <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>\n              patients with significant depressive symptoms (n=37, Center for Epidemiologic Studies Depression score \u226516) and those without (n=49). Phospholipid species were selected using partial least\u2010square discriminant analysis, and the ability of the resulting model to discriminate between groups was evaluated using receiver operator characteristic curves. Biosignature scores were calculated from this model, and analyses of covariance were performed to compare intergroup differences in biosignature scores, with adjustment for clinical differences between patients. Those with significant depressive symptoms had lower cardiopulmonary fitness, more prevalent history of depression, and a greater number of vascular risk factors. A model of 10 phospholipid species had an area under the curve value of 0.84 (95% confidence interval 0.72\u20100.95), sensitivity of 0.73, and specificity of 0.71. This model passed permutation testing (n=1000,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Biosignature scores were higher in those with significant depressive symptoms after adjustment for potential confounders (F[1.86]=14.39,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0005).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The present findings support the role of proinflammatory phospholipid species in the presence of depression in\n              <jats:styled-content style=\"fixed-case\">CAD<\/jats:styled-content>\n              patients from the\n              <jats:styled-content style=\"fixed-case\">CAROTID<\/jats:styled-content>\n              trial (Coronary Artery Disease Randomized Omega\u20103 Trial in Depression). Future investigations should aim to replicate findings in larger data sets and clarify possible pathophysiological mechanisms.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Clinical Trial Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              <jats:styled-content style=\"fixed-case\">URL<\/jats:styled-content>\n              :\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier:\n              <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>\n              00981383.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.117.008278","type":"journal-article","created":{"date-parts":[[2018,5,5]],"date-time":"2018-05-05T09:20:09Z","timestamp":1525512009000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Novel Phospholipid Signature of Depressive Symptoms in Patients With Coronary Artery Disease"],"prefix":"10.1161","volume":"7","author":[{"given":"Parco","family":"Chan","sequence":"first","affiliation":[{"name":"Sunnybrook Research Institute, Toronto, Ontario, Canada"},{"name":"Department of Pharmacology and Toxicology, University of Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivonne","family":"Suridjan","sequence":"additional","affiliation":[{"name":"Sunnybrook Research Institute, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Mohammad","sequence":"additional","affiliation":[{"name":"Sunnybrook Research Institute, Toronto, Ontario, Canada"},{"name":"Department of Pharmacology and Toxicology, University of Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Sunnybrook Research Institute, Toronto, Ontario, Canada"},{"name":"Department of Psychiatry, University of Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"Mazereeuw","sequence":"additional","affiliation":[{"name":"Sunnybrook Research Institute, Toronto, Ontario, Canada"},{"name":"Department of Medicine, University of Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyn M.","family":"Hillyer","sequence":"additional","affiliation":[{"name":"Department of Human Health and Nutritional Sciences, University of Guelph, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W. 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