{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T04:30:14Z","timestamp":1781325014947,"version":"3.54.1"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,8,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In pregnancy, a high plasma volume maintains uteroplacental perfusion and prevents placental ischemia, a condition linked to elevated maternal blood pressure (\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              ). Reducing\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              by increasing Na\n              <jats:sup>+<\/jats:sup>\n              intake via plasma volume expansion appears contra\u2010intuitive. We hypothesize that an appropriate Na\n              <jats:sup>+<\/jats:sup>\n              intake in pregnancy reduces maternal\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              and adapts the renin\u2010angiotensin system in a pregnancy\u2010specific manner.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              was measured by implanted telemetry in Sprague\u2010Dawley rats before and throughout pregnancy. Pregnant and nonpregnant animals received either a normal\u2010salt (0.4%;\n              <jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>\n              ), high\u2010salt (8%;\n              <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n              ), or low\u2010salt (0.01%;\n              <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>\n              ) diet, or\n              <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n              (days 1\u201314) followed by\n              <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>\n              (days 14\u201320) diet (\n              <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n              \/\n              <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>\n              ). Before delivery (day 20), animals were euthanized and organs collected. Food, water, and Na\n              <jats:sup>+<\/jats:sup>\n              intake were monitored in metabolic cages, and urinary creatinine and Na\n              <jats:sup>+<\/jats:sup>\n              were analyzed. Na\n              <jats:sup>+<\/jats:sup>\n              intake and retention increased in pregnancy (\n              <jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>\n              ,\n              <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>\n              ), leading to a positive Na\n              <jats:sup>+<\/jats:sup>\n              balance (\n              <jats:styled-content style=\"fixed-case\">NS<\/jats:styled-content>\n              ,\n              <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>\n              ).\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              was stable during\n              <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>\n              , but reduced in\n              <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n              conditions in pregnancy. The renin\u2010angiotensin system was adapted as expected. Activating cleavage of \u03b1\u2010 and \u03b3\u2010subunits of the renal epithelial Na\n              <jats:sup>+<\/jats:sup>\n              channel and expression of\u2010full length medullary \u03b2\u2010subunits, accentuated further in all\n              <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>\n              conditions, were upregulated in pregnancy.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Pregnancy led to Na\n              <jats:sup>+<\/jats:sup>\n              retention adapted to dietary changes.\n              <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n              exposure paradoxically reduced\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              . Na\n              <jats:sup>+<\/jats:sup>\n              uptake while only modestly linked to the renin\u2010angiotensin system is enhanced in the presence of posttranslational renal epithelial Na\n              <jats:sup>+<\/jats:sup>\n              channel modifications. This suggests (1) storage of Na\n              <jats:sup>+<\/jats:sup>\n              in pregnancy upon\n              <jats:styled-content style=\"fixed-case\">HS<\/jats:styled-content>\n              exposure, bridging periods of\n              <jats:styled-content style=\"fixed-case\">LS<\/jats:styled-content>\n              availability; and\u00a0(2)\u00a0that potentially non\u2013renin\u2010angiotensin\u2013related mechanisms participate in\n              <jats:styled-content style=\"fixed-case\">EN<\/jats:styled-content>\n              aC activation and consecutive Na\n              <jats:sup>+<\/jats:sup>\n              retention.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.117.008363","type":"journal-article","created":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T06:43:15Z","timestamp":1537080195000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Physiological and Molecular Responses to Altered Sodium Intake in Rat Pregnancy"],"prefix":"10.1161","volume":"7","author":[{"given":"Nicole","family":"Eisele","sequence":"first","affiliation":[{"name":"Department of Nephrology and Hypertension University of Bern Switzerland"},{"name":"Department of BioMedical Research University of Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahel","family":"Klossner","sequence":"additional","affiliation":[{"name":"Department of BioMedical Research University of Bern Switzerland"},{"name":"Teaching Hospital Internal Medicine Lindenhofgruppe Berne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevi\u00e8ve","family":"Escher","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension University of Bern Switzerland"},{"name":"Department of BioMedical Research University of Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Rudloff","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Hypertension University of Bern Switzerland"},{"name":"Department of BioMedical Research University of Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexey","family":"Larionov","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine University of Fribourg Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Theilig","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine University of Fribourg Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus G.","family":"Mohaupt","sequence":"additional","affiliation":[{"name":"Department of BioMedical Research University of Bern Switzerland"},{"name":"Teaching Hospital Internal Medicine Lindenhofgruppe Berne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiten D.","family":"Mistry","sequence":"additional","affiliation":[{"name":"Department of BioMedical Research University of Bern Switzerland"},{"name":"Division of Child Health, Obstetrics and Gynaecology School of Medicine City Hospital Nottingham Nottingham United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine","family":"Gennari\u2010Moser","sequence":"additional","affiliation":[{"name":"Department of BioMedical Research University of Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00325.2007"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1042\/cs0450115"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.00157"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.00575"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1998.00217.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2016.02.004"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn763"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-0525"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfl106"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.02320"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-012-1145-4"},{"key":"e_1_3_2_13_2","first-page":"307","article-title":"Replik","volume":"14","author":"Beer M","year":"2014","unstructured":"Beer M. 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