{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:35:04Z","timestamp":1792143304358,"version":"4.4.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,6,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Vasoplegia is associated with adverse outcomes following cardiac surgery; however, its impact following left ventricular assist device implantation is largely unexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      In 252 consecutive patients receiving a left ventricular assist device, vasoplegia was defined as the occurrence of normal cardiac function and index but with the need for intravenous vasopressors within 48\u00a0hours following surgery for &gt;24\u00a0hours to maintain a mean arterial pressure &gt;70\u00a0mm\u00a0Hg. We further categorized vasoplegia as\n                      <jats:italic>none<\/jats:italic>\n                      ;\n                      <jats:italic>mild<\/jats:italic>\n                      , requiring 1 vasopressor (vasopressin, norepinephrine, or high\u2010dose epinephrine [&gt;5\u00a0\u03bcg\/min]); or\n                      <jats:italic>moderate to severe<\/jats:italic>\n                      , requiring \u22652 vasopressors. Predictors of vasoplegia severity were determined using a cumulative logit (ordinal logistic regression) model, and 1\u2010year mortality was evaluated using competing\u2010risks survival analysis. In total, 67 (26.6%) patients developed mild vasoplegia and 57 (22.6%) developed moderate to severe vasoplegia. The multivariable model for vasoplegia severity utilized preoperative Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) profile, central venous pressure, systolic blood pressure, and intraoperative cardiopulmonary bypass time, which yielded an area under the curve of 0.76. Although no significant differences were noted in stroke or pump thrombosis rates (\n                      <jats:italic>P<\/jats:italic>\n                      =0.87 and\n                      <jats:italic>P<\/jats:italic>\n                      =0.66, respectively), respiratory failure and major bleeding increased with vasoplegia severity (\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.01). Those with moderate to severe vasoplegia had a significantly higher risk of mortality than those without vasoplegia (adjusted hazard ratio: 2.12; 95% confidence interval, 1.08\u20134.18;\n                      <jats:italic>P<\/jats:italic>\n                      =0.03).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Vasoplegia is predictive of unfavorable outcomes, including mortality. Risk factors for future research include preoperative\n                      <jats:styled-content style=\"fixed-case\">INTERMACS<\/jats:styled-content>\n                      profile, central venous pressure, systolic blood pressure, and intraoperative cardiopulmonary bypass time.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.117.008377","type":"journal-article","created":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T05:15:20Z","timestamp":1526534120000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":44,"title":["Determinants and Outcomes of Vasoplegia Following Left Ventricular Assist Device Implantation"],"prefix":"10.1161","volume":"7","author":[{"given":"Kristen M.","family":"Tecson","sequence":"first","affiliation":[{"name":"Baylor Heart and Vascular Institute, Baylor Scott &amp; White Research Institute, Dallas, TX"},{"name":"Department of Internal Medicine, Texas A&amp;M University College of Medicine Health Science Center, Dallas, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Lima","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular and Thoracic Surgery, North Shore University Hospital, Manhasset, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy Y.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Baylor University Medical Center, Dallas, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fayez S.","family":"Raza","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Baylor University Medical Center, Dallas, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Ching","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Texas A&amp;M University College of Medicine Health Science Center, Dallas, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010Han","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Texas A&amp;M University College of Medicine Health Science Center, Dallas, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost","family":"Felius","sequence":"additional","affiliation":[{"name":"Annette C. and Harold C. Simmons Transplant Institute, Baylor Scott &amp; White Research Institute, Dallas, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald D.","family":"Baxter","sequence":"additional","affiliation":[{"name":"Department of Surgery, Baylor University Medical Center, Dallas, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasha","family":"Still","sequence":"additional","affiliation":[{"name":"Department of Surgery, Baylor University Medical Center, Dallas, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin D. G.","family":"Collier","sequence":"additional","affiliation":[{"name":"Department of Surgery, Baylor University Medical Center, Dallas, TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelley A.","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Baylor University Medical Center, Dallas, TX"},{"name":"Annette C. and Harold C. 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