{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T02:06:47Z","timestamp":1793239607098,"version":"4.5.0"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,4,17]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We sought to assess the risk of acute kidney injury (\n              <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>\n              ) and mortality associated with intensive systolic blood pressure reduction in acute intracerebral hemorrhage.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Patients with acute intracerebral hemorrhage had spontaneous cause and symptom onset within 24\u00a0hours. We excluded patients with structural causes, coagulopathy, thrombocytopenia, and preexisting end\u2010stage renal disease. We defined\n              <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>\n              using the Acute Kidney Injury Network criteria. Chronic kidney disease status was included in risk stratification and was defined by Kidney Disease Outcomes Quality Initiative staging. Maximum systolic blood pressure reduction was defined over a 12\u2010hour period and dichotomized using receiver operating characteristic curve analysis. Descriptive statistics were done using independent sample\n              <jats:italic>t<\/jats:italic>\n              tests, \u03c7\n              <jats:sup>2<\/jats:sup>\n              tests, and Mann\u2010Whitney\n              <jats:italic>U<\/jats:italic>\n              tests, whereas multivariable logistic regression analysis was used to evaluate for predictors for\n              <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>\n              and mortality. A total of 448 patients with intracerebral hemorrhage met inclusion criteria. Maximum systolic blood pressure reduction was dichotomized to 90\u00a0mm\u00a0Hg and found to increase the risk of\n              <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>\n              in patients with normal renal function (odds ratio, 2.1; 95% confidence interval, 1.19\u20133.62;\n              <jats:italic>P<\/jats:italic>\n              =0.010) and chronic kidney disease (odds ratio, 3.91; 95% confidence interval, 1.26\u201312.15;\n              <jats:italic>P<\/jats:italic>\n              =0.019). The risk of\n              <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>\n              was not significantly different in normal renal function versus chronic kidney disease groups when adjusted for demographics, presentation characteristics, and medications associated with\n              <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>\n              .\n              <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>\n              positively predicted mortality for patients with normal renal function (odds ratio, 2.41; 95% confidence interval, 1.11\u20135.22;\n              <jats:italic>P<\/jats:italic>\n              =0.026) but not for patients with chronic kidney disease (odds ratio, 3.13; 95% confidence interval, 0.65\u201315.01;\n              <jats:italic>P<\/jats:italic>\n              =0.154).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              These results indicate that intensive systolic blood pressure reduction with a threshold &gt;90\u00a0mm\u00a0Hg in patients with acute intracerebral hemorrhage may be an independent predictor for\n              <jats:styled-content style=\"fixed-case\">AKI<\/jats:styled-content>\n              .\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.117.008439","type":"journal-article","created":{"date-parts":[[2018,4,13]],"date-time":"2018-04-13T09:20:13Z","timestamp":1523611213000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":55,"title":["Evaluation of Acute Kidney Injury and Mortality After Intensive Blood Pressure Control in Patients With Intracerebral Hemorrhage"],"prefix":"10.1161","volume":"7","author":[{"given":"L. 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