{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:34:11Z","timestamp":1790076851619,"version":"4.0.1"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,6,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Cerebral microbleeds (CMBs) are hypothesized downstream markers of brain damage caused by vascular and amyloid pathologic mechanisms. The aim of this study was to determine whether CMB count and location are associated with an increased risk for mild cognitive impairment (MCI) in patients with essential hypertension without a history of transient ischemic attack or stroke.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In this cross\u2010sectional study, patients were prospectively enrolled from consecutive outpatients with essential hypertension 50\u00a0years and older at 3 centers in northern China. Generalized linear Poisson models were used to determine the association between the number and location of\n              <jats:styled-content style=\"fixed-case\">CMB<\/jats:styled-content>\n              s and\n              <jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>\n              in patients with hypertension. The association of microbleeds with different cognitive domains was estimated using linear mixed models. The presence, number, and distribution of\n              <jats:styled-content style=\"fixed-case\">CMB<\/jats:styled-content>\n              s were greater in patients with hypertension who had\n              <jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>\n              (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). The presence of any\n              <jats:styled-content style=\"fixed-case\">CMB<\/jats:styled-content>\n              s, strictly lobar\n              <jats:styled-content style=\"fixed-case\">CMB<\/jats:styled-content>\n              s, and deep or infratentorial\n              <jats:styled-content style=\"fixed-case\">CMB<\/jats:styled-content>\n              s were all related to\n              <jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>\n              after adjusting for age, sex, education, cardiovascular risk factors, body mass index, intima\u2010media thickness, the presence of silent lacunar infarctions, white matter lesion grade, and brain atrophy. Furthermore, the presence of multiple microbleeds (\u22655) was associated with lower Montreal Cognitive Assessment total scores and worse performance on specific domains of cognitive tests, such as global cognitive function, information processing speed, and motor speed.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              This study suggests that the presence of and a greater number of cerebral\n              <jats:styled-content style=\"fixed-case\">CMB<\/jats:styled-content>\n              s independently correlate with\n              <jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>\n              in patients with essential hypertension without a history of transient ischemic attack or stroke.\n            <\/jats:p>\n          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