{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T08:16:16Z","timestamp":1762157776920,"version":"3.41.2"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,7,17]]},"abstract":"\n Background<\/jats:title>\n \n Ischemic cardiomyopathy (\n ICM<\/jats:styled-content>\n ) and dilated cardiomyopathy (\n DCM<\/jats:styled-content>\n ) differ in histopathology and prognosis. Although transendocardial delivery of mesenchymal stem cells is safe and provides cardiovascular benefits in both, a comparison of mesenchymal stem cell efficacy in\n ICM<\/jats:styled-content>\n versus\n DCM<\/jats:styled-content>\n has not been done.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We conducted a subanalysis of 3 single\u2010center, randomized, and blinded clinical trials: (1) TAC\u2010HFT (Transendocardial Autologous Mesenchymal Stem Cells and Mononuclear Bone Marrow Cells in Ischemic Heart Failure Trial); (2)\u00a0POSEIDON (A Phase I\/II, Randomized Pilot Study of the Comparative Safety and Efficacy of Transendocardial Injection of Autologous Mesenchymal Stem Cells Versus Allogeneic Mesenchymal Stem Cells in Patients With Chronic Ischemic Left Ventricular Dysfunction Secondary to Myocardial Infarction); and (3) POSEIDON\u2010DCM (Percutaneous Stem Cell Injection Delivery Effects on Neomyogenesis in Dilated Cardiomyopathy). Baseline and 1\u2010year cardiac structure and function and quality\u2010of\u2010life data were compared in a post hoc pooled analysis including\n ICM<\/jats:styled-content>\n (n=46) and\n DCM<\/jats:styled-content>\n (n=33) patients who received autologous or allogeneic mesenchymal stem cells. Ejection fraction improved in\n DCM<\/jats:styled-content>\n by 7% (within\u2010group,\n P<\/jats:italic>\n =0.002) compared to\n ICM<\/jats:styled-content>\n (1.5%; within\u2010group,\n P<\/jats:italic>\n =0.14; between\u2010group,\n P<\/jats:italic>\n =0.003). Similarly, stroke volume increased in\n DCM<\/jats:styled-content>\n by 10.59\u00a0mL (\n P<\/jats:italic>\n =0.046) versus\n ICM<\/jats:styled-content>\n (\u22120.2\u00a0mL;\n P<\/jats:italic>\n =0.73; between\u2010group,\n P<\/jats:italic>\n =0.02). End\u2010diastolic volume improved only in\n ICM<\/jats:styled-content>\n (10.6\u00a0mL;\n P<\/jats:italic>\n =0.04) and end\u2010systolic volume improved only in\n DCM<\/jats:styled-content>\n (17.8\u00a0mL;\n P<\/jats:italic>\n =0.049). The sphericity index decreased only in\n ICM<\/jats:styled-content>\n (\u22120.04;\n P<\/jats:italic>\n =0.0002). End\u2010diastolic mass increased in\n ICM<\/jats:styled-content>\n (23.1\u00a0g;\n P<\/jats:italic>\n <0.0001) versus\n DCM<\/jats:styled-content>\n (\u22124.1\u00a0g;\n P<\/jats:italic>\n =0.34; between\u2010group,\n P<\/jats:italic>\n =0.007). The 6\u2010minute walk test improved in\n DCM<\/jats:styled-content>\n (31.1\u00a0m;\n P<\/jats:italic>\n =0.009) and\n ICM<\/jats:styled-content>\n (36.3\u00a0m;\n P<\/jats:italic>\n =0.006) with no between\u2010group difference (\n P<\/jats:italic>\n =0.79). The New York Heart Association class improved in\n DCM<\/jats:styled-content>\n (\n P<\/jats:italic>\n =0.005) and\n ICM<\/jats:styled-content>\n (\n P<\/jats:italic>\n =0.02; between\u2010group\n P<\/jats:italic>\n =0.20). The Minnesota Living with Heart Failure Questionnaire improved in\n DCM<\/jats:styled-content>\n (\u221219.5;\n P<\/jats:italic>\n =0.002) and\n ICM<\/jats:styled-content>\n (\u22126.4;\n P<\/jats:italic>\n =0.03; \u03b4 between\u2010group difference\n P<\/jats:italic>\n =0.042) patients.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Mesenchymal stem cell therapy is beneficial in\n DCM<\/jats:styled-content>\n and\n ICM<\/jats:styled-content>\n patients, despite variable effects on cardiac phenotypic outcomes. Whereas cardiac function improved preferentially in\n DCM<\/jats:styled-content>\n patients,\n ICM<\/jats:styled-content>\n patients experienced reverse remodeling. Mesenchymal stem cell therapy enhanced quality of life and functional capacity in both etiologies.\n <\/jats:p>\n <\/jats:sec>\n \n Clinical Trial Registration<\/jats:title>\n \n URL<\/jats:styled-content>\n :\n http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n . Unique identifiers:\n TAC<\/jats:styled-content>\n \u2010\n HFT<\/jats:styled-content>\n :\n NCT<\/jats:styled-content>\n 00768066,\n POSEIDON<\/jats:styled-content>\n :\n NCT<\/jats:styled-content>\n 01087996,\n POSEIDON<\/jats:styled-content>\n \u2010\n DCM<\/jats:styled-content>\n :\n NCT<\/jats:styled-content>\n 01392625.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.117.008460","type":"journal-article","created":{"date-parts":[[2018,7,12]],"date-time":"2018-07-12T09:15:49Z","timestamp":1531386949000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":30,"title":["Comparison of Mesenchymal Stem Cell Efficacy in Ischemic Versus Nonischemic Dilated Cardiomyopathy"],"prefix":"10.1161","volume":"7","author":[{"given":"Bryon A.","family":"Tompkins","sequence":"first","affiliation":[{"name":"Interdisciplinary Stem Cell Institute University of Miami Miller School of Medicine Miami FL"},{"name":"Department of Surgery University of 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Cell Institute University of Miami Miller School of Medicine Miami FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evan D.","family":"Nigh","sequence":"additional","affiliation":[{"name":"Interdisciplinary Stem Cell Institute University of Miami Miller School of Medicine Miami FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Marie","family":"Landin","sequence":"additional","affiliation":[{"name":"Interdisciplinary Stem Cell Institute University of Miami Miller School of Medicine Miami FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianna M.","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Interdisciplinary Stem Cell Institute University of Miami Miller School of Medicine Miami FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos E.","family":"Hatzistergos","sequence":"additional","affiliation":[{"name":"Interdisciplinary Stem Cell Institute University of Miami Miller School 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