{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T21:23:52Z","timestamp":1775942632698,"version":"3.50.1"},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,10,2]]},"abstract":"\n Background<\/jats:title>\n Niacin is a broad\u2010spectrum lipid\u2010modulating drug, but its mechanism of action is unclear. Genome\u2010wide association studies have identified multiple loci associated with blood lipid levels and lipoprotein (a). It is unknown whether these loci modulate response to niacin.<\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Using data from the\n AIM<\/jats:styled-content>\n \u2010\n HIGH<\/jats:styled-content>\n (Atherothrombosis Intervention in Metabolic Syndrome with Low\n HDL<\/jats:styled-content>\n \/High Triglycerides and Impact on Global Health Outcomes) trial (n=2054 genotyped participants), we determined whether genetic variations at validated loci were associated with a differential change in plasma lipids and lipoprotein (a) 1\u00a0year after randomization to either statin+placebo or statin+niacin in a variant\u2010treatment interaction model. Nominally significant interactions (\n P<\/jats:italic>\n <0.05) were found for genetic variants in\n \n MVK<\/jats:styled-content>\n <\/jats:italic>\n ,\n \n LIPC<\/jats:styled-content>\n ,\n PABPC<\/jats:styled-content>\n 4,\n AMPD<\/jats:styled-content>\n 3\n <\/jats:italic>\n with change in high\u2010density lipoprotein cholesterol;\n \n SPTLC<\/jats:styled-content>\n 3\n <\/jats:italic>\n with change in low\u2010density lipoprotein cholesterol;\n \n TOM<\/jats:styled-content>\n 1\n <\/jats:italic>\n with change in total cholesterol;\n \n PDXDC<\/jats:styled-content>\n 1\n <\/jats:italic>\n and\n \n CYP<\/jats:styled-content>\n 26A1\n <\/jats:italic>\n with change in triglycerides; and none for lipoprotein (a). We also investigated whether these loci were associated with cardiovascular events. The risk of coronary disease related death was higher in the minor allele carriers at the\n \n LIPC<\/jats:styled-content>\n <\/jats:italic>\n locus in the placebo group (odds ratio 2.08, 95% confidence interval 1.11\u20103.90,\n P<\/jats:italic>\n =0.02) but not observed in the niacin group (odds ratio 0.89, 95% confidence interval 0.48\u20101.65,\n P<\/jats:italic>\n =0.7);\n P<\/jats:italic>\n \u2010interaction =0.02. There was a greater risk for acute coronary syndrome (odds ratio 1.85, 95% confidence interval 1.16\u20102.77,\n P<\/jats:italic>\n =0.02) and revascularization events (odds ratio 1.64, 95% confidence interval 1.2\u20102.22,\n P<\/jats:italic>\n =0.002) in major allele carriers at the\n \n CYP<\/jats:styled-content>\n 26A1\n <\/jats:italic>\n locus in the placebo group not seen in the niacin group.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Genetic variation at loci previously associated with steady\u2010state lipid levels displays evidence for lipid response to niacin treatment.<\/jats:p>\n <\/jats:sec>\n \n Clinical Trials Registration<\/jats:title>\n \n URL:\n https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n . Unique identifier: NCT00120289.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.117.008461","type":"journal-article","created":{"date-parts":[[2018,9,30]],"date-time":"2018-09-30T08:43:08Z","timestamp":1538296988000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Genetic Variants Associated With Plasma Lipids Are Associated With the Lipid Response to Niacin"],"prefix":"10.1161","volume":"7","author":[{"given":"Sony","family":"Tuteja","sequence":"first","affiliation":[{"name":"Department of Medicine Perelman School of Medicine at the University of Pennsylvania Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liming","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Medicine Perelman School of Medicine at the University of Pennsylvania Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marijana","family":"Vujkovic","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology Perelman School of Medicine at the University of Pennsylvania Philadelphia PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard L.","family":"Dunbar","sequence":"additional","affiliation":[{"name":"Department of Medicine Perelman School of Medicine at the University of Pennsylvania Philadelphia PA"},{"name":"Cardiometabolic and Lipid Clinic Corporal Michael J. 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