{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:13:21Z","timestamp":1791638001372,"version":"4.3.4"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,5,15]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The clinical significance of long\u2010term seasonal variations in self\u2010measured home blood pressure (\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              ) has not been elucidated for the cardiovascular disease prevention.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Eligible 2787 patients were classified into 4 groups according to the magnitude of their seasonal variation in home\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              , defined as an average of all increases in home\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              from summer (July\u2013August) to winter (January\u2013February) combined with all decreases from winter to summer throughout the follow\u2010up period, namely inverse\u2010 (systolic\/diastolic, &lt;0\/&lt;0\u00a0mm\u00a0Hg), small\u2010 (0\u20134.8\/0\u20132.4\u00a0mm\u00a0Hg), middle\u2010 (4.8\u20139.1\/2.4\u20134.5\u00a0mm\u00a0Hg), or large\u2010 (\u22659.1\/\u22654.5\u00a0mm\u00a0Hg) variation groups. The overall cardiovascular risks illustrated U\u2010shaped relationships across the groups, and hazard ratios for all cardiovascular outcomes compared with the small\u2010variation group were 3.07 (\n              <jats:italic>P<\/jats:italic>\n              =0.004) and 2.02 (\n              <jats:italic>P<\/jats:italic>\n              =0.041) in the inverse\u2010variation group and large\u2010variation group, respectively, based on systolic\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              , and results were confirmatory for major adverse cardiovascular events. Furthermore, when the summer\u2010winter home\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              difference was evaluated among patients who experienced titration and tapering of antihypertensive drugs depending on the season, the difference was significantly smaller in the early (September\u2013November) than in the late (December\u2013February) titration group (3.9\/1.2\u00a0mm\u00a0Hg versus 7.3\/3.1\u00a0mm\u00a0Hg,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) as well as in the early (March\u2013May) than in the late (June\u2013August) tapering group (4.4\/2.1\u00a0mm\u00a0Hg versus 7.1\/3.4\u00a0mm\u00a0Hg,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The small\u2010to\u2010middle seasonal variation in home\n              <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>\n              (0\u20139.1\/0\u20134.5\u00a0mm\u00a0Hg), which may be partially attributed to earlier adjustment of antihypertensive medication, were associated with better cardiovascular outcomes.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.117.008509","type":"journal-article","created":{"date-parts":[[2018,5,4]],"date-time":"2018-05-04T09:20:12Z","timestamp":1525425612000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":57,"title":["Association Between Amplitude of Seasonal Variation in Self\u2010Measured Home Blood Pressure and Cardiovascular Outcomes: HOMED\u2010BP (Hypertension Objective Treatment Based on Measurement By Electrical Devices of Blood Pressure) Study"],"prefix":"10.1161","volume":"7","author":[{"given":"Tomohiro","family":"Hanazawa","sequence":"first","affiliation":[{"name":"Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, Japan"},{"name":"Japan Development and Medical Affairs, GlaxoSmithKline KK, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Asayama","sequence":"additional","affiliation":[{"name":"Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, Japan"},{"name":"Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan"},{"name":"Tohoku Institute for Management of Blood Pressure, Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Watabe","sequence":"additional","affiliation":[{"name":"Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, Japan"},{"name":"Department of Pharmacy, National Cancer Center Hospital, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayumi","family":"Tanabe","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health, School of Medicine, Keio University, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michihiro","family":"Satoh","sequence":"additional","affiliation":[{"name":"Division of Public Health, Hygiene and Epidemiology, Tohoku Medical and Pharmaceutical University Faculty of Medicine, Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryusuke","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics, Tohoku University Graduate School of Medicine, Sendai, 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Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Public Health, Teikyo University School of Medicine, Tokyo, Japan"},{"name":"Department of Public Health, Akita University Graduate School of Medicine, Akita, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirohito","family":"Metoki","sequence":"additional","affiliation":[{"name":"Division of Public Health, Hygiene and Epidemiology, Tohoku Medical and Pharmaceutical University Faculty of Medicine, Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Imai","sequence":"additional","affiliation":[{"name":"Department of Planning for Drug Development and Clinical Evaluation, Tohoku University Graduate School of Pharmaceutical Sciences, Sendai, Japan"},{"name":"Tohoku Institute for Management of Blood Pressure, Sendai, 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