{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:56:49Z","timestamp":1790787409418,"version":"4.1.0"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,1,8]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">We aimed to determine the change in treatment strategies and times to treatment over the first 5\u00a0years of the Mission: Lifeline program.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We assessed pre\u2010 and in\u2010hospital care and outcomes from 2008 to 2012 for patients with\n              <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>\n              \u2010segment\u2013elevation myocardial infarction at US hospitals, using data from the National Cardiovascular Data Registry Acute Coronary Treatment and Intervention Outcomes Network Registry\u2014Get With The Guidelines Registry. In\u2010hospital adjusted mortality was calculated including and excluding cardiac arrest as a reason for primary percutaneous coronary intervention delay. A total of 147\u00a0466 patients from 485 hospitals were analyzed. There was a decrease in the proportion of eligible patients not treated with reperfusion (6.2% versus 3.3%) and treated with fibrinolytic therapy (13.4% versus 7.0%). Median time from symptom onset to first medical contact was unchanged (\u224850\u00a0minutes). Use of prehospital ECGs increased (45% versus 71%). All major reperfusion times improved: median first\u00a0medical contact\u2010to\u2010device for emergency medical systems transport to percutaneous coronary intervention\u2013capable hospitals (93 to 84\u00a0minutes), first door\u2010to\u2010device for transfers for primary percutaneous coronary intervention (130 to 112\u00a0minutes), and door\u2010in\u2013door\u2010out at non\u2013percutaneous coronary intervention\u2013capable hospitals (76 to 62\u00a0minutes) (all\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001 over 5\u00a0years). Rates of cardiogenic shock and cardiac arrest, and overall in\u2010hospital mortality increased (5.7% to 6.3%). Adjusted mortality excluding patients with known cardiac arrest decreased by 14% at 3\u00a0years and 25% at 5\u00a0years (\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Quality of care for patients with\n              <jats:styled-content style=\"fixed-case\">ST<\/jats:styled-content>\n              \u2010segment\u2013elevation myocardial infarction improved over time in Mission: Lifeline, including increased use of reperfusion therapy and faster times\u2010to\u2010treatment. In\u2010hospital mortality improved for patients without cardiac arrest but did not appear to improve overall as the number of these high\u2010risk patients increased.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.118.008096","type":"journal-article","created":{"date-parts":[[2018,12,31]],"date-time":"2018-12-31T10:00:19Z","timestamp":1546250419000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":93,"title":["Improving Care of STEMI in the United States 2008 to 2012"],"prefix":"10.1161","volume":"8","author":[{"given":"Christopher B.","family":"Granger","sequence":"first","affiliation":[{"name":"Division of Cardiology Duke Clinical Research Institute Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric R.","family":"Bates","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Michigan Ann Arbor MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James G.","family":"Jollis","sequence":"additional","affiliation":[{"name":"Division of Cardiology Duke Clinical Research Institute Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliott M.","family":"Antman","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"Nichol","sequence":"additional","affiliation":[{"name":"University of Washington\u2010Harborview Center for Prehospital Emergency Care University of Washington Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.","family":"O'Connor","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine University of Virginia School of Medicine Charlottesville VA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammy","family":"Gregory","sequence":"additional","affiliation":[{"name":"American Heart Association Dallas TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayme L.","family":"Roettig","sequence":"additional","affiliation":[{"name":"Division of Cardiology Duke Clinical Research Institute Durham NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Andrew","family":"Peng","sequence":"additional","affiliation":[{"name":"MD Anderson Cancer Center Houston TX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gray","family":"Ellrodt","sequence":"additional","affiliation":[{"name":"Department of Medicine Berkshire Medical Center Pittsfield MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy D.","family":"Henry","sequence":"additional","affiliation":[{"name":"Cedars\u2010Sinai Heart Institute Los Angeles CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"French","sequence":"additional","affiliation":[{"name":"Department of Medicine Harbor\u2010University of California at Los Angeles Medical Center Torrance CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice K.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Department of Medicine Boston University School of Medicine Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91161-4"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12113-7"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.184043"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.111.964668"},{"key":"e_1_3_2_6_2","unstructured":"American Heart Association . Mission: Lifeline website. Available at: http:\/\/www.heart.org\/HEARTORG\/HealthcareResearch\/MissionLifelineHomePage\/Mission-Lifeline-Home-Page_UCM_305495_SubHomePage.jsp. Accessed April 4 2017."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3182742c84"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.108.847145"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2010.10.004"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2014.04.029"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.862"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.118463"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.068049"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.114.002450"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2014.6573"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.033118"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1208200"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61932-2"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.11.073"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.019474"},{"key":"e_1_3_2_21_2","first-page":"10","article-title":"AHA\/ACC clinical performance and quality measures for adults with ST\u2010elevation and non\u2010ST\u2010elevation myocardial infarction: a report of the American College of Cardiology\/American Heart Association Task Force on Performance Measures","volume":"2017","author":"Jneid H","year":"2017","unstructured":"Jneid H, Addison D, Bhatt DL, Fonarow GC, Gokak S, Grady KL, Green LA, Heidenreich PA, Ho PM, Jurgens CY, King ML, Kumbhani DJ, Pancholy S. AHA\/ACC clinical performance and quality measures for adults with ST\u2010elevation and non\u2010ST\u2010elevation myocardial infarction: a report of the American College of Cardiology\/American Heart Association Task Force on Performance Measures. Circ Cardiovasc Qual Outcomes. 2017;2017:10.","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3181cdb7db"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.118.008096","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:10:05Z","timestamp":1715598605000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.118.008096"}},"subtitle":["A Report From the American Heart Association Mission: Lifeline Program"],"short-title":[],"issued":{"date-parts":[[2019,1,8]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1,8]]}},"alternative-id":["10.1161\/JAHA.118.008096"],"URL":"https:\/\/doi.org\/10.1161\/jaha.118.008096","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,8]]},"assertion":[{"value":"2018-04-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e008096"}}