{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:23:58Z","timestamp":1790709838142,"version":"4.1.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,5,15]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              New data on extracranial carotid atherosclerosis are needed, as improved ultrasound techniques may detect more atherosclerosis, the definition of plaque has changed over the years, and better cardiovascular risk control in the population may have changed patterns of carotid arterial wall disease and actual prevalence of established cardiovascular disease. We investigated the prevalence of atherosclerotic carotid plaques and carotid intima\u2013media thickness (\n              <jats:styled-content style=\"fixed-case\">cIMT<\/jats:styled-content>\n              ) and their relation to cardiovascular risk factors in a middle\u2010aged cohort from the general population.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We performed carotid ultrasound in 3683 participants who were born in 1950 and included in a population\u2010based Norwegian study. Carotid plaque and c\n              <jats:styled-content style=\"fixed-case\">IMT<\/jats:styled-content>\n              were assessed according to the Mannheim Carotid Intima\u2013Media Thickness and Plaque Consensus,\u00a0and a carotid plaque score was used to calculate atherosclerotic burden. The participants were aged 63 to 65\u00a0years, and 49% were women. The prevalence of established cardiovascular disease was low (10%), but 62% had hypertension, 53% had hypercholesterolemia, 11% had diabetes mellitus, and 23% were obese. Mean\n              <jats:styled-content style=\"fixed-case\">cIMT<\/jats:styled-content>\n              was 0.73\u00b10.11\u00a0mm, and atherosclerotic carotid plaques were present in 87% of the participants (median plaque score: 2; interquartile range: 3). Most of the cardiovascular risk factors, with the exception of diabetes mellitus, obesity and waist\u2013hip ratio, were independently associated with the plaque score. In contrast, only sex, hypertension, obesity, current smoking, and cerebrovascular disease were associated with\n              <jats:styled-content style=\"fixed-case\">cIMT<\/jats:styled-content>\n              .\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We found very high prevalence of carotid plaque in this middle\u2010aged population, and our data support a greater association between cardiovascular risk factors and plaque burden, compared with\n              <jats:styled-content style=\"fixed-case\">cIMT<\/jats:styled-content>\n              .\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Clinical Trial Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              <jats:styled-content style=\"fixed-case\">URL<\/jats:styled-content>\n              :\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier:\n              <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>\n              01555411.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.118.008562","type":"journal-article","created":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T09:20:09Z","timestamp":1525771209000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":43,"title":["Prevalence of Carotid Plaque in a 63\u2010 to 65\u2010Year\u2010Old Norwegian Cohort From the General Population: The ACE (Akershus Cardiac Examination) 1950 Study"],"prefix":"10.1161","volume":"7","author":[{"given":"H\u00e5kon","family":"Ihle\u2010Hansen","sequence":"first","affiliation":[{"name":"Department of Medical Research, B\u00e6rum Hospital, Vestre Viken Hospital Trust, Drammen, Norway"},{"name":"Institute of Clinical Medicine, University of Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thea","family":"Vigen","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Oslo, Norway"},{"name":"Division of Medicine, Akershus University Hospital, L\u00f8renskog, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hege","family":"Ihle\u2010Hansen","sequence":"additional","affiliation":[{"name":"Department of Medical Research, B\u00e6rum Hospital, Vestre Viken Hospital Trust, Drammen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole Morten","family":"R\u00f8nning","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Oslo, Norway"},{"name":"Division of Medicine, Akershus University Hospital, L\u00f8renskog, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trygve","family":"Berge","sequence":"additional","affiliation":[{"name":"Department of Medical Research, B\u00e6rum Hospital, Vestre Viken Hospital Trust, Drammen, Norway"},{"name":"Institute of Clinical Medicine, University of Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bente","family":"Thommessen","sequence":"additional","affiliation":[{"name":"Division of Medicine, Akershus University Hospital, L\u00f8renskog, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus Nakrem","family":"Lyngbakken","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Oslo, Norway"},{"name":"Division of Medicine, Akershus University Hospital, L\u00f8renskog, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eivind Bj\u00f8rkan","family":"Orstad","sequence":"additional","affiliation":[{"name":"Division of Medicine, Akershus University Hospital, L\u00f8renskog, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Enger","sequence":"additional","affiliation":[{"name":"Department of Medical Research, B\u00e6rum Hospital, Vestre Viken Hospital Trust, Drammen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e5le","family":"Nyg\u00e5rd","sequence":"additional","affiliation":[{"name":"Bioinformatics core facility, Oslo University Hospital and the University of Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helge","family":"R\u00f8sj\u00f8","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine, University of Oslo, Norway"},{"name":"Division of Medicine, Akershus University Hospital, L\u00f8renskog, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnljot","family":"Tveit","sequence":"additional","affiliation":[{"name":"Department of Medical Research, B\u00e6rum Hospital, Vestre Viken Hospital Trust, Drammen, Norway"},{"name":"Institute of Clinical Medicine, University of Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/362801a0"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-009-0004-1"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.25.12.2377"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000018650.58984.75"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2005.09.006"},{"key":"e_1_3_4_7_2","first-page":"308","article-title":"Heart and brain interactions\u2014the Akershus Cardiac Examination (ACE) 1950 study design","volume":"49","author":"Berge T","year":"2015","unstructured":"Berge T, Vigen T, Pervez MO, Ihle\u2010Hansen H, Lyngbakken MN, Omland T, Smith P, Steine K, Rosjo H, Tveit A. 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