{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T14:56:58Z","timestamp":1792421818026,"version":"4.5.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,7,17]]},"abstract":"\n Background<\/jats:title>\n The usefulness of vascular function tests for management of patients with a history of coronary artery disease is not fully known.<\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We measured flow\u2010mediated vasodilation (\n FMD<\/jats:styled-content>\n ) and brachial\u2013ankle pulse wave velocity (ba\n PWV<\/jats:styled-content>\n ) in 462 patients with coronary artery disease for assessment of the predictive value of\n FMD<\/jats:styled-content>\n and ba\n PWV<\/jats:styled-content>\n for future cardiovascular events in a prospective multicenter observational study. The first primary outcome was coronary events, and the second primary outcome was a composite of coronary events, stroke, heart failure, and sudden death. During a median follow\u2010up period of 49.2\u00a0months, the first primary outcome occurred in 56 patients and the second primary outcome occurred in 66 patients.\n FMD<\/jats:styled-content>\n above the cutoff value of 7.1%, derived from receiver\u2010operator curve analyses for the first and second primary outcomes, was significantly associated with lower risk of the first (hazard ratio, 0.27; 95% confidence interval, 0.06\u20130.74;\n P<\/jats:italic>\n =0.008) and second (hazard ratio, 0.32; 95% confidence interval, 0.09\u20130.79;\n P<\/jats:italic>\n =0.01) primary outcomes. ba\n PWV<\/jats:styled-content>\n above the cutoff value of 1731\u00a0cm\/s was significantly associated with higher risk of the first (hazard ratio, 1.86; 95% confidence interval, 1.01\u20133.44;\n P<\/jats:italic>\n =0.04) and second (hazard ratio, 2.19; 95% confidence interval, 1.23\u20133.90;\n P<\/jats:italic>\n =0.008) primary outcomes. Among 4 groups stratified according to the combination of cutoff values of\n FMD<\/jats:styled-content>\n and ba\n PWV<\/jats:styled-content>\n , stepwise increases in the calculated risk ratio for the first and second primary outcomes were observed.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n In patients with coronary artery disease, both\n FMD<\/jats:styled-content>\n and ba\n PWV<\/jats:styled-content>\n were significant predictors of cardiovascular events. The combination of\n FMD<\/jats:styled-content>\n and ba\n PWV<\/jats:styled-content>\n provided further cardiovascular risk stratification.\n <\/jats:p>\n <\/jats:sec>\n \n Clinical Trial Registration<\/jats:title>\n \n URL<\/jats:styled-content>\n :\n www.umin.ac.jp<\/jats:ext-link>\n . Unique identifier:\n UMIN<\/jats:styled-content>\n 000012950.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.118.008588","type":"journal-article","created":{"date-parts":[[2018,7,12]],"date-time":"2018-07-12T09:15:49Z","timestamp":1531386949000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":108,"title":["Endothelial Dysfunction, Increased Arterial Stiffness, and Cardiovascular Risk Prediction in Patients With Coronary Artery Disease: FMD\u2010J (Flow\u2010Mediated Dilation Japan) Study A"],"prefix":"10.1161","volume":"7","author":[{"given":"Tatsuya","family":"Maruhashi","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junko","family":"Soga","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Graduate School 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