{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:07:28Z","timestamp":1792098448702,"version":"4.4.0"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,4,17]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Carotid atherosclerosis (\n              <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>\n              ) is a reflector of generalized atherosclerosis that is associated with systemic vascular disease. Data are limited on the epidemiology of carotid lesions in a large, nationally representative population sample. We aimed to evaluate the prevalence of\n              <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>\n              detected by carotid ultrasonography and related risk factors based on a national survey in China.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              A total of 107\u00a0095 residents aged \u226540\u00a0years from the China National Stroke Prevention Project underwent carotid ultrasound examination. Participants with carotid endarterectomy or carotid stenting and those with stroke or coronary heart disease were excluded. Data from 84\u00a0880 participants were included in the analysis.\n              <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>\n              was defined as increased intima\u2013media thickness (\n              <jats:styled-content style=\"fixed-case\">IMT<\/jats:styled-content>\n              ) \u22651\u00a0mm or presence of plaques. Of the 84\u00a0880 participants, 46.4% were men, and the mean age was 60.7\u00b110.3\u00a0years. The standardized prevalence of\n              <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>\n              was 36.2% overall, increased with age, and was higher in men than in women. Prevalence of\n              <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>\n              was higher among participants living in rural areas than in urban areas. Approximately 26.5% of participants had increased\n              <jats:styled-content style=\"fixed-case\">IMT,<\/jats:styled-content>\n              and 13.9% presented plaques. There was an age\u2010related increase in participants with increased\n              <jats:styled-content style=\"fixed-case\">IMT<\/jats:styled-content>\n              , plaque presence, and stenosis. In multiple logistic regression analysis, older age, male sex, residence in rural areas, smoking, alcohol consumption, physical inactivity, obesity, hypertension, diabetes mellitus, and dyslipidemia were associated with\n              <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>\n              .\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>\n              was highly prevalent in a middle\u2010aged and older Chinese population. This result shows the potential clinical importance of focusing on primary prevention of atherosclerosis progression.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.118.008701","type":"journal-article","created":{"date-parts":[[2018,4,5]],"date-time":"2018-04-05T09:05:15Z","timestamp":1522919115000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":93,"title":["Carotid Atherosclerosis Detected by Ultrasonography: A National Cross\u2010Sectional Study"],"prefix":"10.1161","volume":"7","author":[{"given":"Xiaojun","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fujian","family":"Song","sequence":"additional","affiliation":[{"name":"Norwich Medical School, Faculty of Medicine and Health Science, University of East Anglia, Norwich, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longde","family":"Wang","sequence":"additional","affiliation":[{"name":"The National Health and Family Commission, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Fu","sequence":"additional","affiliation":[{"name":"School of Medicine and Health Management, Tongji Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyi","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Gan","sequence":"additional","affiliation":[{"name":"Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound, Tongji Hospital &amp; Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Xuanwu Hospital Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhuan","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Science and Education, The Third Hospital of Shijiazhuang, Shijiazhuang, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Harrison International Peace Hospital, Hengshui, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Science and Education, People's Hospital of Deyang City, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Rizhao People's Hospital, Rizhao, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Shenzhen Second People's Hospital Shenzhen University, Shenzhen, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuxun","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000128517.52533.DB"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/hh1601.095596"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep33960"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000018650.58984.75"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)30073-4"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.016921"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.8.727"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2006.00085.x"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.11.075"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000147723.52033.9e"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(02)00017-5"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(01)06255-9"},{"key":"e_1_3_5_14_2","first-page":"83","article-title":"Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults\u2014study on optimal cut\u2010off points of body mass index and waist circumference in Chinese adults","volume":"15","author":"Zhou BF","year":"2002","unstructured":"Zhou BF. 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