{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T15:24:44Z","timestamp":1781537084902,"version":"3.54.5"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,7,3]]},"abstract":"\n Background<\/jats:title>\n \n Previous intravascular ultrasound studies suggested the association of stent underexpansion with increased risk of stent thrombosis and restenosis. However, no previous study has addressed the association of the suboptimal angiographic result with target\u2010lesion revascularization (\n TLR<\/jats:styled-content>\n ) in patients receiving new\u2010generation drug\u2010eluting stents (\n DES<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n RESET<\/jats:styled-content>\n (Randomized evaluation of sirolimus\u2010eluting versus everolimus\u2010eluting stent trial) and\n NEXT<\/jats:styled-content>\n (NOBORI biolimus\u2010eluting versus XIENCE\/PROMUS everolimus\u2010eluting stent trial) are prospective, multicenter, randomized \u201c\n DES<\/jats:styled-content>\n versus\n DES<\/jats:styled-content>\n \u201d trials; 3196 patients and 3235 patients were enrolled in the\n RESET<\/jats:styled-content>\n and\n NEXT<\/jats:styled-content>\n , respectively. Using the pooled individual patient\u2010level data, the current study population consisted of 3679 patients who received single\u2010lesion treatment using new\u2010generation\n DES<\/jats:styled-content>\n such as everolimus\u2010eluting stent and biolimus\u2010eluting stent. The study population was divided into 3 groups according to the residual in\u2010stent % diameter stenosis (%\n DS<\/jats:styled-content>\n ) after stent implantation by offline quantitative coronary angiography assessed in a core angiographic laboratory (optimal group: %\n DS<\/jats:styled-content>\n <10%, intermediate group: %\n DS<\/jats:styled-content>\n =10% to 20%, suboptimal group: %\n DS<\/jats:styled-content>\n \u226720%). The cumulative 3\u2010year incidence of\n TLR<\/jats:styled-content>\n was significantly higher in the suboptimal group than in the intermediate and optimal groups (9.8% versus 5.8% versus 5.7%, log\u2010rank\n P<\/jats:italic>\n =0.004). Even after adjusting for the clinical, angiographic, and procedural characteristics, the excess\n TLR<\/jats:styled-content>\n risk of the suboptimal group relative to the optimal group remained significant (hazard ratio: 1.65, 95% confidence interval, 1.14\u20132.41,\n P<\/jats:italic>\n =0.009). The excess\n TLR<\/jats:styled-content>\n risk of the suboptimal group relative to the optimal group was consistently seen across all the subgroups including heavy calcification.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n The residual angiographic in\u2010stent %\n DS<\/jats:styled-content>\n \u226520% was associated with increased risk for\n TLR<\/jats:styled-content>\n in patients treated with the new\u2010generation\n DES<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.118.008718","type":"journal-article","created":{"date-parts":[[2018,6,30]],"date-time":"2018-06-30T09:15:10Z","timestamp":1530350110000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Impact of Angiographic Residual Stenosis on Clinical Outcomes After New\u2010Generation Drug\u2010Eluting Stents Implantation: Insights From a Pooled Analysis of the RESET and NEXT Trials"],"prefix":"10.1161","volume":"7","author":[{"given":"Hiroki","family":"Watanabe","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Morimoto","sequence":"additional","affiliation":[{"name":"Division of General Medicine Department of Internal Medicine Hyogo College of Medicine Nishinomiya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Shiomi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Natsuaki","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Saga University Saga 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Memorial Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Morino","sequence":"additional","affiliation":[{"name":"Department of Cardiology Iwate University Hospital Morioka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Hibi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Yokohama City University Medical Center Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Akasaka","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Wakayama Medical University Hospital Wakayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Cardiology National Hospital Organization Kyoto Medical Center Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Suwa","sequence":"additional","affiliation":[{"name":"Department of Cardiology Juntendo University Shizuoka Hospital Nagaoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiya","family":"Muramatsu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Saiseikai Yokohama\u2010City Eastern Hospital Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakazu","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hamamatsu Medical Center Hamamatsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuoki","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hiroshima City Hospital Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Nakao","sequence":"additional","affiliation":[{"name":"Division of Cardiology Chikamori Hospital Kochi Japan"},{"name":"Department of Cardiology Saiseikai Kumamoto Hospital Cardiovascular Center Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Tarutani","sequence":"additional","affiliation":[{"name":"Department of Cardiology Okamura Memorial Hospital Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenshi","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sakurabashi Watanabe Hospital Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the RESET and NEXT Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","first-page":"58","article-title":"ACCF\/AHA\/SCAI guideline for percutaneous coronary intervention","volume":"2011","author":"Levine GN","year":"2011","unstructured":"Levine GN, Bates ER, Blankenship JC, Bailey SR, Bittl JA, Cercek B, Chambers CE, Ellis SG, Guyton RA, Hollenberg SM, Khot UN, Lange RA, Mauri L, Mehran R, Moussa ID, Mukherjee D, Nallamothu BK, Ting HH, Jacobs AK, Anderson JL, Albert N, Creager MA, Ettinger SM, Halperin JL, Hochman JS, Kushner FG, Ohman EM, Stevenson W, Yancy CW. 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