{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:31:35Z","timestamp":1787959895756,"version":"build-2784847793"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,8,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              This study assessed trends in heart failure (\n              <jats:styled-content style=\"fixed-case\">HF)<\/jats:styled-content>\n              hospitalizations and health resource use in patients with adult congenital heart disease (\n              <jats:styled-content style=\"fixed-case\">ACHD<\/jats:styled-content>\n              ).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The Nationwide Inpatient Sample was used to compare\n              <jats:styled-content style=\"fixed-case\">ACHD<\/jats:styled-content>\n              with non\u2010\n              <jats:styled-content style=\"fixed-case\">ACHD HF<\/jats:styled-content>\n              hospitalization and health resource trends. Health resource use was assessed using total hospital charges, hospital length of stay, and procedural burden. A total of 87\u00a0175\u00b12676\n              <jats:styled-content style=\"fixed-case\">ACHD<\/jats:styled-content>\n              \u2010related\n              <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>\n              hospitalizations occurred between 1998 and 2011. During this time,\n              <jats:styled-content style=\"fixed-case\">ACHD HF<\/jats:styled-content>\n              hospitalizations increased 91% (4620\u00b1438\u20138809\u00b1740,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001) versus a 21% increase in non\u2010\n              <jats:styled-content style=\"fixed-case\">ACHD HF<\/jats:styled-content>\n              hospitalizations (\n              <jats:italic>P<\/jats:italic>\n              =0.003).\n              <jats:styled-content style=\"fixed-case\">ACHD HF<\/jats:styled-content>\n              hospitalization was associated with longer length of stay (\n              <jats:styled-content style=\"fixed-case\">ACHD HF<\/jats:styled-content>\n              versus non\u2010\n              <jats:styled-content style=\"fixed-case\">ACHD HF,<\/jats:styled-content>\n              7.2\u00b10.09 versus 6.8\u00b10.02\u00a0days;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001), greater procedural burden, and higher charges ($81\u00a0332\u00b1$1650 versus $52\u00a0050\u00b1$379;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001).\n              <jats:styled-content style=\"fixed-case\">ACHD HF<\/jats:styled-content>\n              hospitalization charges increased 258% during the study period ($26\u00a0533\u00b1$1816 in 1998 versus $94\u00a0887\u00b1$8310 in 2011;\n              <jats:italic>P<\/jats:italic>\n              =0.0002), more than double that for non\u2010\n              <jats:styled-content style=\"fixed-case\">ACHD HF<\/jats:styled-content>\n              (\n              <jats:italic>P<\/jats:italic>\n              =0.04). Patients with\n              <jats:styled-content style=\"fixed-case\">ACHD HF<\/jats:styled-content>\n              hospitalized in high\u2010volume\n              <jats:styled-content style=\"fixed-case\">ACHD<\/jats:styled-content>\n              centers versus others were more likely to undergo invasive hemodynamic testing (30.2\u00b10.6% versus 20.7\u00b10.5%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001) and to receive cardiac resynchronization\/defibrillator devices (4.7\u00b10.3% versus 1.8\u00b10.2%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001) and mechanical circulatory support (3.9\u00b10.2% versus 2.4\u00b10.2%;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.0001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              <jats:styled-content style=\"fixed-case\">ACHD<\/jats:styled-content>\n              \u2010related\n              <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>\n              hospitalizations have increased dramatically in recent years and are associated with disproportionately higher costs, procedural burden, and health resource use.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.118.008775","type":"journal-article","created":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T06:43:15Z","timestamp":1537080195000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":81,"title":["Hospitalization Trends and Health Resource Use for Adult Congenital Heart Disease\u2013Related Heart Failure"],"prefix":"10.1161","volume":"7","author":[{"given":"Luke J.","family":"Burchill","sequence":"first","affiliation":[{"name":"Adult Congenital Heart Disease Program Knight Cardiovascular Institute Oregon Health and Science University Portland OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Gao","sequence":"additional","affiliation":[{"name":"Adult Congenital Heart Disease Program Knight Cardiovascular Institute Oregon Health and Science University Portland OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienne H.","family":"Kovacs","sequence":"additional","affiliation":[{"name":"Adult Congenital Heart Disease Program Knight Cardiovascular Institute Oregon Health and Science University Portland OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander R.","family":"Opotowsky","sequence":"additional","affiliation":[{"name":"Boston Children's Hospital and Brigham and Women's Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan G.","family":"Maxwell","sequence":"additional","affiliation":[{"name":"Legacy Emanuel Medical Center and Randall Children's Hospital Portland OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Minnier","sequence":"additional","affiliation":[{"name":"Adult Congenital Heart Disease Program Knight Cardiovascular Institute Oregon Health and Science University Portland OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail M.","family":"Khan","sequence":"additional","affiliation":[{"name":"Adult Congenital Heart Disease Program Knight Cardiovascular Institute Oregon Health and Science University Portland OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig S.","family":"Broberg","sequence":"additional","affiliation":[{"name":"Adult Congenital Heart Disease Program Knight Cardiovascular Institute Oregon Health and Science University Portland OR"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.019307"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.05.040"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)01169-3"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2010.07.018"},{"key":"e_1_3_1_6_2","first-page":"385A","article-title":"One thousand patients with adult congenital heart disease: causes of death and lessons learned","volume":"29","author":"Connolly HM","year":"1997","unstructured":"Connolly HM, Ammash, NM, Warnes C. 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