{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:20:01Z","timestamp":1790695201873,"version":"4.1.0"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,11,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Despite growing use of the subcutaneous implantable cardioverter\u2010defibrillator (S\u2010\n              <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>\n              ), its clinical role in arrhythmogenic right ventricular cardiomyopathy\/dysplasia (\n              <jats:styled-content style=\"fixed-case\">ARVC<\/jats:styled-content>\n              \/D) patients remains undefined. We aim to elucidate the cardiac phenotype, implant characteristics, and long\u2010term efficacy regarding appropriate therapy and complications in\n              <jats:styled-content style=\"fixed-case\">ARVC<\/jats:styled-content>\n              \/D patients with an S\u2010\n              <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>\n              implant.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              A transatlantic cohort of\n              <jats:styled-content style=\"fixed-case\">ARVC<\/jats:styled-content>\n              \/D patients who underwent S\u2010\n              <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>\n              implantation was analyzed for clinical characteristics, S\u2010\n              <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>\n              therapy, and long\u2010term outcome including device\u2010related complications. The cohort included 29 patients (52% male, 76% probands, 59% with\n              <jats:styled-content style=\"fixed-case\">ARVC<\/jats:styled-content>\n              \/D\u2010associated mutation, 59% primary prevention [no prior sustained ventricular arrhythmias], and 45% first\u2010generation S\u2010\n              <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>\n              devices). At implant, all inducible patients (27\/29) had conversion of induced ventricular fibrillation. Two patients (7%) had superficial infections of the incision site that were treated conservatively. Over a median follow\u2010up of 3.16 years (interquartile range: 2.21\u20134.51 years), all episodes (6 patients, 4% per year) of sustained ventricular arrhythmias were appropriately detected and treated. Six patients (21%) experienced 39 inappropriate shocks, with 3 requiring device explantation. Oversensing of noncardiac signal (n=4; especially myopotentials) and cardiac signal (n=4) was the most frequent etiology. No lead or device dislodgement, infection, skin erosion, or explantation related to need for antitachycardia pacing was noted.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              S\u2010\n              <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>\n              can effectively treat both induced and spontaneous ventricular arrhythmias in patients with\n              <jats:styled-content style=\"fixed-case\">ARVC<\/jats:styled-content>\n              \/D. The rate of inappropriate shocks, although considerable, is comparable to that in\n              <jats:styled-content style=\"fixed-case\">ARVC<\/jats:styled-content>\n              \/D patients treated with transvenous\n              <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>\n              s. When they occurred, inappropriate shocks were primarily due to cardiac and, uniquely, noncardiac oversensing. We suggest potential strategies for minimizing inappropriate therapy.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.118.008782","type":"journal-article","created":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T09:00:11Z","timestamp":1540544411000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":26,"title":["Subcutaneous Implantable Cardioverter\u2010Defibrillator in Patients With Arrhythmogenic Right Ventricular Cardiomyopathy\/Dysplasia: A Transatlantic Experience"],"prefix":"10.1161","volume":"7","author":[{"given":"Gabriela M.","family":"Orgeron","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Medicine Johns Hopkins Hospital Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditya","family":"Bhonsale","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Johns Hopkins Hospital Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Migliore","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Cardiac Thoracic and Vascular Sciences University of Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia A.","family":"James","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Johns Hopkins Hospital Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crystal","family":"Tichnell","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Johns Hopkins Hospital Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittney","family":"Murray","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Johns Hopkins Hospital Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Bertaglia","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Cardiac Thoracic and Vascular Sciences University of Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Cadrin\u2010Tourigny","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Johns Hopkins Hospital Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"De Franceschi","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Cardiac Thoracic and Vascular Sciences University of Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Crosson","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Johns Hopkins Hospital Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harikrishna","family":"Tandri","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Johns Hopkins Hospital Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Corrado","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Cardiac Thoracic and Vascular Sciences University of Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugh","family":"Calkins","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Johns Hopkins Hospital Baltimore 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