{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T16:26:19Z","timestamp":1787934379169,"version":"build-2784847793"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,7,17]]},"abstract":"\n Background<\/jats:title>\n \n Arterial stiffening and atherosclerosis tend to coexist. Strain imaging, using a 2\u2010dimensional speckle tracking (2D\u2010\n ST<\/jats:styled-content>\n ) method, has been used for arterial stiffness assessment and early identification of atherosclerosis. We investigated whether the ascending aortic strain assessed by 2D\u2010\n ST<\/jats:styled-content>\n echocardiography at rest can predict the presence of coronary artery disease (\n CAD<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Two hundred seventy\u2010one consecutive patients with suspected stable angina pectoris sequentially underwent exercise treadmill testing, 2\u2010dimensional echocardiography, M\u2010mode echocardiography, 2D\u2010\n ST<\/jats:styled-content>\n echocardiography, and coronary angiography. Circumferential ascending aortic strain (\n CAAS<\/jats:styled-content>\n ) and radial ascending aortic strain were assessed by 2D\u2010\n ST<\/jats:styled-content>\n echocardiography. Ninety\u2010two patients with coronary lumen area stenosis \u226570% were categorized as having significant\n CAD<\/jats:styled-content>\n . Global\n CAAS<\/jats:styled-content>\n was significantly lower in patients with significant\n CAD<\/jats:styled-content>\n (7.41\u00b12.30% versus 11.54\u00b14.03%;\n P<\/jats:italic>\n <0.001) and remained an independent predictor of significant\n CAD<\/jats:styled-content>\n (odds ratio, 0.64 [0.54\u20130.75];\n P<\/jats:italic>\n <0.001) after multivariate regression. Based on the receiver operating characteristic curve for diagnosing significant\n CAD<\/jats:styled-content>\n , the optimal cut\u2010off value of global\n CAAS<\/jats:styled-content>\n was \u22649.22% (sensitivity, 86%; specificity, 70%; area under curve=0.82;\n P<\/jats:italic>\n <0.001). Global\n CAAS<\/jats:styled-content>\n decreased with increasing severity of\n CAD<\/jats:styled-content>\n and was significantly associated with 3\u2010vessel disease (odds ratio, 0.58 [0.42\u20130.79];\n P<\/jats:italic>\n <0.001). Diagnostics for significant\n CAD<\/jats:styled-content>\n were remarkably better for global\n CAAS<\/jats:styled-content>\n combined with exercise treadmill testing than for exercise treadmill testing alone (area under curve=0.88 versus 0.78;\n P<\/jats:italic>\n <0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Global\n CAAS<\/jats:styled-content>\n assessed by 2D\u2010\n ST<\/jats:styled-content>\n echocardiography at rest was able to predict the presence of significant\n CAD<\/jats:styled-content>\n and identify multivessel disease. In addition, global\n CAAS<\/jats:styled-content>\n combined with exercise treadmill testing remarkably improved the diagnostics for significant\n CAD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.118.008802","type":"journal-article","created":{"date-parts":[[2018,7,7]],"date-time":"2018-07-07T05:15:12Z","timestamp":1530940512000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Ascending Aortic Strain Analysis Using 2\u2010Dimensional Speckle Tracking Echocardiography Improves the Diagnostics for Coronary Artery Stenosis in Patients With Suspected Stable Angina Pectoris"],"prefix":"10.1161","volume":"7","author":[{"given":"Zhaohui","family":"Bu","sequence":"first","affiliation":[{"name":"Institute of Biomedical Engineering University of Shanghai for Science and Technology Shanghai China"},{"name":"Department of Cardiology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibo","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqing","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongping","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Zheng","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering University of Shanghai for Science and Technology Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuedong","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"He","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"},{"name":"Department of Cardiology Shanghai Chest Hospital Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Pu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.12.017"},{"key":"e_1_3_1_3_2","first-page":"233","article-title":"Ultrasonographic vascular mechanics to assess arterial stiffness: a review","volume":"2016","author":"Teixeira R","year":"2015","unstructured":"Teixeira R, Vieira MJ, Gon\u00e7alves A, Cardim N, Gon\u00e7alves L. 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