{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:03:28Z","timestamp":1793318608841,"version":"4.5.0"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,7,3]]},"abstract":"\n Background<\/jats:title>\n \n Although implantation of a left ventricular assist device (\n LVAD<\/jats:styled-content>\n ) generally improves tricuspid regurgitation (\n TR<\/jats:styled-content>\n ) in short\u2010term follow\u2010up, the clinical significance of residual\n TR<\/jats:styled-content>\n in patients with mid\u2010 to long\u2010term\n LVAD<\/jats:styled-content>\n support is unknown. This study aimed to identify the prevalence, predictors, and prognostic value of residual\n TR<\/jats:styled-content>\n in\n LVAD<\/jats:styled-content>\n patients in association with tricuspid valve (\n TV<\/jats:styled-content>\n ) deformation.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n The study cohort consisted of 127 patients who underwent\n LVAD<\/jats:styled-content>\n implantation without\n TV<\/jats:styled-content>\n procedure and were supported with\n LVAD<\/jats:styled-content>\n at least 1\u00a0year. All patients underwent echocardiographic examination preoperatively and 1\u00a0year after\n LVAD<\/jats:styled-content>\n implantation.\n TR<\/jats:styled-content>\n was quantitatively assessed by ratio of\n TR<\/jats:styled-content>\n color jet area\/right atrial area, and significant residual\n TR<\/jats:styled-content>\n was defined as \u226520% of %\n TR<\/jats:styled-content>\n at follow\u2010up echocardiographic examination. Detailed echocardiographic measurements were also performed, including\n TV<\/jats:styled-content>\n annulus diameter,\n TV<\/jats:styled-content>\n leaflet displacement, and left ventricular and right ventricular systolic function.\n LVAD<\/jats:styled-content>\n implantation significantly improved ratio of\n TR<\/jats:styled-content>\n color jet area\/right atrial area as well as left ventricular and right ventricular systolic function and tethering distance (all\n P<\/jats:italic>\n <0.05), whereas it enlarged\n TV<\/jats:styled-content>\n annulus diameter (\n P<\/jats:italic>\n =0.002). Significant residual\n TR<\/jats:styled-content>\n was observed in 30 (23.6%) patients. Age, preoperative\n TV<\/jats:styled-content>\n annulus diameter, and residual mitral regurgitation were significantly associated with significant residual\n TR<\/jats:styled-content>\n (all\n P<\/jats:italic>\n <0.05), whereas\n TV<\/jats:styled-content>\n tethering was not. During a mean follow\u2010up of 21\u00b117\u00a0months, patients with residual\n TR<\/jats:styled-content>\n had significantly higher mortality than those without residual\n TR<\/jats:styled-content>\n (log\u2010rank\n P<\/jats:italic>\n <0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Significant residual\n TR<\/jats:styled-content>\n was observed in \u224825% patients supported with\n LVAD<\/jats:styled-content>\n over 1\u00a0year and was associated with unfavorable outcome.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.118.008813","type":"journal-article","created":{"date-parts":[[2018,6,24]],"date-time":"2018-06-24T09:19:51Z","timestamp":1529831991000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":42,"title":["Prevalence, Predictors, and Prognostic Value of Residual Tricuspid Regurgitation in Patients With Left Ventricular Assist Device"],"prefix":"10.1161","volume":"7","author":[{"given":"Koki","family":"Nakanishi","sequence":"first","affiliation":[{"name":"Department of Medicine Columbia University New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunichi","family":"Homma","sequence":"additional","affiliation":[{"name":"Department of Medicine Columbia University New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiho","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Surgery Columbia University New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroo","family":"Takayama","sequence":"additional","affiliation":[{"name":"Department of Surgery Columbia University New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo C.","family":"Colombo","sequence":"additional","affiliation":[{"name":"Department of Medicine Columbia University New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melana","family":"Yuzefpolskaya","sequence":"additional","affiliation":[{"name":"Department of Medicine Columbia University New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur R.","family":"Garan","sequence":"additional","affiliation":[{"name":"Department of Medicine Columbia University New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryjane A.","family":"Farr","sequence":"additional","affiliation":[{"name":"Department of Medicine Columbia University New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Kurlansky","sequence":"additional","affiliation":[{"name":"Department of Surgery Columbia University New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco R.","family":"Di Tullio","sequence":"additional","affiliation":[{"name":"Department of Medicine Columbia University New York 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