{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:19:46Z","timestamp":1780471186899,"version":"3.54.1"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,9,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Cystathionine is an intermediate product in the transsulfuration pathway and formed during the B6\u2010dependent conversion of methionine to cysteine. Elevated plasma cystathionine has been related to atherosclerosis, which is a major etiological factor for ischemic stroke. However, the role of cystathionine in stroke development is unknown. Therefore, we prospectively assessed the association of circulating levels of cystathionine with risk of total and ischemic stroke.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">Two\u2010thousand thirty\u2010six patients (64% men; median age, 62\u00a0years) undergoing coronary angiography for suspected stable angina pectoris were included. Stroke cases were identified by linkage to the CVDNOR (Cardiovascular Disease in Norway) project. Hazard ratios with confidence intervals (95% confidence interval) were estimated by using Cox\u2010regression analyses. During 7.3\u00a0years of median follow\u2010up, 124 (6.1%) incident strokes were ascertained, which comprised 100 cases of ischemic stroke. There was a positive association of plasma cystathionine with risk of total stroke and ischemic stroke. Comparing the fourth versus the first cystathionine quartiles, age\u2010 and sex\u2010adjusted hazard ratios (95% confidence interval) were 2.11 (1.19\u20133.75) and 2.56 (1.31\u20134.99) for total and ischemic stroke, respectively. Additional adjustment for major stroke risk factors only slightly attenuated the associations, which tended to be stronger in patients without previous or existing atrial fibrillation at baseline (hazard ratio [95% confidence interval], 2.43 [1.27\u20134.65] and 2.88 [1.39\u20135.98] for total and ischemic stroke, respectively).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In patients with suspected stable angina pectoris, plasma cystathionine was independently related to increased risk of total stroke and, in particular, ischemic stroke.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Clinical Trial Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              <jats:styled-content style=\"fixed-case\">URL<\/jats:styled-content>\n              :\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier:\n              <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>\n              00354081.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.118.008824","type":"journal-article","created":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T18:20:49Z","timestamp":1537208449000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Plasma Cystathionine and Risk of Incident Stroke in Patients With Suspected Stable Angina Pectoris"],"prefix":"10.1161","volume":"7","author":[{"given":"Indu","family":"Dhar","sequence":"first","affiliation":[{"name":"Department of Clinical Science University of Bergen Norway"},{"name":"KG Jebsen Centre for Diabetes Research University of Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gard F.T.","family":"Svingen","sequence":"additional","affiliation":[{"name":"Department of Heart Disease Haukeland University Hospital Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per M.","family":"Ueland","sequence":"additional","affiliation":[{"name":"Department of Clinical Science University of Bergen Norway"},{"name":"Bevital AS Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vegard","family":"Lysne","sequence":"additional","affiliation":[{"name":"Department of Clinical Science University of Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mads M.","family":"Svenningsson","sequence":"additional","affiliation":[{"name":"Department of Heart Disease Haukeland University Hospital Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grethe S.","family":"Tell","sequence":"additional","affiliation":[{"name":"Department of Global Public Health and Primary Care University of Bergen Norway"},{"name":"Norwegian Institute of Public Health Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ottar K.","family":"Nyg\u00e5rd","sequence":"additional","affiliation":[{"name":"Department of Clinical Science University of Bergen Norway"},{"name":"KG Jebsen Centre for Diabetes Research University of Bergen Norway"},{"name":"Department of Heart Disease Haukeland University Hospital Bergen Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4949.2009.00387.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/79.1.76"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1079\/BJN20061729"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(95)05740-4"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/1759091415578711"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2011.01.008"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.147439"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/hh1401.093459"},{"key":"e_1_3_2_10_2","first-page":"40","article-title":"Pathogenesis of atherosclerosis\u2014a multifactorial process","volume":"7","author":"Singh RB","year":"2002","unstructured":"Singh RB, Mengi SA, Xu YJ, Arneja AS, Dhalla NS. 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