{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T06:14:02Z","timestamp":1783577642838,"version":"3.55.0"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"23","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,12,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Cardiac autonomic neuropathy is thought to cause adverse cardiovascular effects in diabetes mellitus. Pulmonary vein ganglia (\n              <jats:styled-content style=\"fixed-case\">PVG<\/jats:styled-content>\n              ), which have been implicated in normal and abnormal heart rhythm regulation, have not been fully investigated in type 1 diabetes mellitus (T1D). We examined the functional and anatomical effects of T1D on\n              <jats:styled-content style=\"fixed-case\">PVG<\/jats:styled-content>\n              and studied the details of T1D\u2010induced remodeling on the\n              <jats:styled-content style=\"fixed-case\">PVG<\/jats:styled-content>\n              structure and function.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We used a mouse model of T1D (Akita mouse), immunofluorescence, isolated Langendorff\u2010perfused hearts, and mathematical simulations to explore the effects of T1D on\n              <jats:styled-content style=\"fixed-case\">PVG<\/jats:styled-content>\n              . Whole\u2010mount atrial immunofluorescence of choline acetyltransferase and tyrosine hydroxylase labeling showed that sympathetic and parasympathetic somas of the\n              <jats:styled-content style=\"fixed-case\">PVG<\/jats:styled-content>\n              neurons were significantly hypotrophied in T1D hearts versus wild type. Stimulation of\n              <jats:styled-content style=\"fixed-case\">PVG<\/jats:styled-content>\n              in isolated Langendorff\u2010perfused hearts caused more pronounced P\u2010P interval prolongation in\n              <jats:styled-content style=\"fixed-case\">wild type<\/jats:styled-content>\n              compared with Akita hearts. Propranolol resulted in a comparable P\u2010P prolongation in both phenotypes, and atropine led to more pronounced P\u2010P interval shortening in\n              <jats:styled-content style=\"fixed-case\">wild type<\/jats:styled-content>\n              compared with Akita hearts. Numerical modeling using network simulations revealed that a decrease in the sympathetic and parasympathetic activities of\n              <jats:styled-content style=\"fixed-case\">PVG<\/jats:styled-content>\n              in T1D could explain the experimental results.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              T1D leads to\n              <jats:styled-content style=\"fixed-case\">PVG<\/jats:styled-content>\n              remodeling with hypotrophy of sympathetic and parasympathetic cell bodies and a concomitant decrease in the\n              <jats:styled-content style=\"fixed-case\">PVG<\/jats:styled-content>\n              sympathetic and parasympathetic activities.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.118.008919","type":"journal-article","created":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T17:05:47Z","timestamp":1543943147000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":11,"title":["Pulmonary Vein Ganglia Are Remodeled in the Diabetic Heart"],"prefix":"10.1161","volume":"7","author":[{"given":"Guillaume","family":"Bassil","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Weill Cornell Medical College New York NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology and Physiology Morsani College of Medicine University of South Florida Tampa FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrys","family":"Pauza","sequence":"additional","affiliation":[{"name":"Laboratories for Integrative Neuroscience and Endocrinology University of Bristol United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesus","family":"Diaz Vera","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology and Physiology Morsani College of Medicine University of South Florida Tampa FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios","family":"Tsalatsanis","sequence":"additional","affiliation":[{"name":"Research Methodology and Biostatistics Morsani College of Medicine University of South Florida Tampa FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce G.","family":"Lindsey","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology and Physiology Morsani College of Medicine University of South Florida Tampa FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami F.","family":"Noujaim","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology and Physiology Morsani College of Medicine University of South Florida Tampa FL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1891\/0739-6686.31.47"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.2337\/db16-0806"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-5491.2002.00821.x"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00059-002-2340-4"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.634949"},{"key":"e_1_3_1_7_2","first-page":"346","article-title":"Myocardial dysfunction and adrenergic innervation in patients with Type 1 diabetes mellitus","volume":"13","author":"Scognamiglio R","year":"2000","unstructured":"Scognamiglio R, Casara D, Avogaro A. 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