{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T19:30:02Z","timestamp":1782934202784,"version":"3.54.5"},"reference-count":57,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,7,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Adipokines mediate cardiometabolic risk associated with obesity but their role in the pathogenesis of obesity\u2010associated heart failure remains uncertain. We investigated the associations between circulating adipokine concentrations and echocardiographic measures in a community\u2010based sample.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We evaluated 3514 Framingham Heart Study participants (mean age 40\u00a0years, 53.8% women) who underwent routine echocardiography and had select circulating adipokines measured, ie, leptin, soluble leptin receptor, fatty acid\u2013binding protein 4, retinol\u2010binding protein 4, fetuin\u2010A, and adiponectin. We used multivariable linear regression, adjusting for known correlates (including weight), to relate adipokine concentrations (independent variables) to the following echocardiographic measures (dependent variables): left ventricular mass index, left atrial diameter in end systole, fractional shortening, and E\/e\u2032. In multivariable\u2010adjusted analysis, left ventricular mass index was inversely related to circulating leptin and fatty acid\u2013binding protein 4 concentrations but positively related to retinol\u2010binding protein 4 and leptin receptor levels (\n              <jats:italic>P<\/jats:italic>\n              \u22640.002 for all). Left atrial end\u2010systolic dimension was inversely related to leptin but positively related to retinol\u2010binding protein 4 concentrations (\n              <jats:italic>P<\/jats:italic>\n              \u22640.0001). E\/e\u2032 was inversely related to leptin receptor levels (\n              <jats:italic>P<\/jats:italic>\n              =0.0002). We observed effect modification by body weight for select associations (leptin receptor and fatty acid\u2013binding protein 4 with left ventricular mass index, and leptin with left atrial diameter in end systole;\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05 for interactions). Fractional shortening was not associated with any of the adipokines. No echocardiographic trait was associated with fetuin\u2010A or adiponectin concentrations.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In our cross\u2010sectional study of a large, young to middle\u2010aged, relatively healthy community\u2010based sample, key indices of subclinical cardiac remodeling were associated with higher or lower circulating concentrations of prohypertrophic and antihypertrophic adipokines in a context\u2010specific manner. These observations may offer insights into the pathogenesis of the cardiomyopathy of obesity.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.118.008997","type":"journal-article","created":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T09:15:34Z","timestamp":1529572534000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":22,"title":["Association of Circulating Adipokines With Echocardiographic Measures of Cardiac Structure and Function in a Community\u2010Based Cohort"],"prefix":"10.1161","volume":"7","author":[{"given":"Beatrice","family":"von Jeinsen","sequence":"first","affiliation":[{"name":"Boston University's and National Heart, Lung, and Blood Institute's Framingham Heart Study Framingham MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meghan I.","family":"Short","sequence":"additional","affiliation":[{"name":"Boston University's and National Heart, Lung, and Blood Institute's Framingham 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