{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:51:26Z","timestamp":1791982286492,"version":"4.4.0"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,7,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Catheter ablation of ventricular tachycardia (\n              <jats:styled-content style=\"fixed-case\">VT<\/jats:styled-content>\n              ) is associated with the risk of cerebral embolism. The origin of periprocedural brain embolism in the setting of\n              <jats:styled-content style=\"fixed-case\">VT<\/jats:styled-content>\n              ablation is often unknown and strategies to avoid it are sparse. The aim of this study was to assess the safety and feasibility of an endovascular 2\u2010filter\u2010based cerebral protection system (\n              <jats:styled-content style=\"fixed-case\">CPS<\/jats:styled-content>\n              ) in left ventricular\n              <jats:styled-content style=\"fixed-case\">VT<\/jats:styled-content>\n              ablation procedures in patients with ischemic heart disease. Furthermore, histopathological correlates of periprocedural embolization were investigated.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In this pilot study, 11 patients with ischemic heart disease and sustained\n              <jats:styled-content style=\"fixed-case\">VT<\/jats:styled-content>\n              underwent left ventricular catheter ablation under\n              <jats:styled-content style=\"fixed-case\">CPS<\/jats:styled-content>\n              surveillance. The placement of the\n              <jats:styled-content style=\"fixed-case\">CPS<\/jats:styled-content>\n              was conducted before the ablation procedure via the right radial artery. The\n              <jats:styled-content style=\"fixed-case\">VT<\/jats:styled-content>\n              ablation procedure was performed via a combined transaortic and transseptal approach. All\n              <jats:styled-content style=\"fixed-case\">VT<\/jats:styled-content>\n              s were successfully ablated. Placement and retrieval of the\n              <jats:styled-content style=\"fixed-case\">CPS<\/jats:styled-content>\n              was successful and safe in all cases. No periprocedural complications related to the\n              <jats:styled-content style=\"fixed-case\">CPS<\/jats:styled-content>\n              were observed and no periprocedural transient ischemic attack or stroke occurred. Debris captured by the\n              <jats:styled-content style=\"fixed-case\">CPS<\/jats:styled-content>\n              was detected in all patients. Histology revealed that acute thrombus was the most common type of debris (91%), followed by arterial wall tissue (73%) and foreign material (55%). Less frequently found were myocardium (27%), calcification (9%), necrotic core (9%), and valve tissue (9%).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Cerebral protection during\n              <jats:styled-content style=\"fixed-case\">VT<\/jats:styled-content>\n              ablation seems to be safe and feasible. Ablation procedures of\n              <jats:styled-content style=\"fixed-case\">VT<\/jats:styled-content>\n              are associated with embolization of embolic debris, which was found in every patient.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.118.009005","type":"journal-article","created":{"date-parts":[[2018,6,30]],"date-time":"2018-06-30T09:15:10Z","timestamp":1530350110000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":24,"title":["Cerebral Protection During Catheter Ablation of Ventricular Tachycardia in Patients With Ischemic Heart Disease"],"prefix":"10.1161","volume":"7","author":[{"given":"Christian\u2010Hendrik","family":"Heeger","sequence":"first","affiliation":[{"name":"Department for Cardiology Asklepios Klinik St. Georg Hamburg Germany"},{"name":"University Heart Center Luebeck Luebeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Metzner","sequence":"additional","affiliation":[{"name":"Department for Cardiology Asklepios Klinik St. Georg Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schl\u00fcter","sequence":"additional","affiliation":[{"name":"Asklepios Proresearch Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Rillig","sequence":"additional","affiliation":[{"name":"Department for Cardiology Asklepios Klinik St. Georg Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shibu","family":"Mathew","sequence":"additional","affiliation":[{"name":"Department for Cardiology Asklepios Klinik St. Georg Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland Richard","family":"Tilz","sequence":"additional","affiliation":[{"name":"University Heart Center Luebeck Luebeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Wohlmuth","sequence":"additional","affiliation":[{"name":"Asklepios Proresearch Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria E.","family":"Romero","sequence":"additional","affiliation":[{"name":"CV Path Institute, Inc. 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