{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T08:09:40Z","timestamp":1788941380031,"version":"build-2803163510"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"17","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,9,4]]},"abstract":"\n Background<\/jats:title>\n \n Transthoracic echocardiography (\n TTE<\/jats:styled-content>\n ) is often considered for risk stratification of patients with acute pulmonary embolism (\n PE<\/jats:styled-content>\n ). We sought to determine the contemporary utilization of early\n TTE<\/jats:styled-content>\n (within 72\u00a0hours of\n PE<\/jats:styled-content>\n diagnosis) and explored the association between\n TTE<\/jats:styled-content>\n findings and\n PE<\/jats:styled-content>\n \u2010related mortality.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Data from the RIETE (Registro Informatizado Enfermedad TromboEmbolica) registry, a multicenter registry of consecutive patients with acute\n PE<\/jats:styled-content>\n , were used (2001\u2013July 2017). We used a generalized linear mixed model to determine predictors of early\n TTE<\/jats:styled-content>\n performance. Moreover, the association between 3\n TTE<\/jats:styled-content>\n variables (right atrial enlargement, right ventricular hypokinesis, and presence of right heart thrombi) and 30\u2010day\n PE<\/jats:styled-content>\n \u2010related mortality was assessed in generalized linear mixed models adjusted for\n PE<\/jats:styled-content>\n severity index, and other comorbidities. Among 35\u00a0935 enrollees with acute\n PE<\/jats:styled-content>\n , 15\u00a0375 (42.8%) underwent early\n TTE<\/jats:styled-content>\n . There was an increase in early\n TTE<\/jats:styled-content>\n utilization rate over time (\n P<\/jats:italic>\n <0.001 for trend). Younger age, female sex, enrollment in countries other than Spain, history of coronary disease, heart failure, atrial fibrillation, tachycardia, and hypotension were the main predictors of early\n TTE<\/jats:styled-content>\n (\n P<\/jats:italic>\n <0.01 for all). In multivariable analyses, right atrial enlargement (adjusted odds ratio: 3.74; 95% confidence interval, 2.10\u20136.66), right ventricular hypokinesis (adjusted odds ratio: 3.11, 95% confidence interval: 1.85\u20135.21) and right heart thrombi (adjusted odds ratio: 4.39, 95% confidence interval, 1.99\u20139.71) were associated with increased odds for\n PE<\/jats:styled-content>\n \u2010related mortality.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Early\n TTE<\/jats:styled-content>\n is commonly performed for acute\n PE<\/jats:styled-content>\n and utilization rates have increased over time. Right atrial enlargement, right ventricular hypokinesis, and right heart thrombi are predictive of worse outcomes.\n <\/jats:p>\n <\/jats:sec>\n \n Clinical Trial Registration<\/jats:title>\n \n URL<\/jats:styled-content>\n :\n http:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n . Unique identifier:\n NCT<\/jats:styled-content>\n 02832245.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.118.009042","type":"journal-article","created":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T18:20:49Z","timestamp":1537208449000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":46,"title":["Early Use of Echocardiography in Patients With Acute Pulmonary Embolism: Findings From the RIETE Registry"],"prefix":"10.1161","volume":"7","author":[{"given":"Behnood","family":"Bikdeli","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Medicine Columbia University Medical Center\/New York\u2010Presbyterian Hospital New York NY"},{"name":"Yale\/YNHH Center for Outcomes Research & Evaluation New Haven CT"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"Lobo","sequence":"additional","affiliation":[{"name":"Department of Pneumonology Hospital Universitario 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