{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:54:57Z","timestamp":1787018097614,"version":"build-2736575974"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,7,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Venous thromboembolism (\n                      <jats:styled-content style=\"fixed-case\">VTE<\/jats:styled-content>\n                      ) is the third leading cause of vascular disease and accounts for $10\u00a0billion in annual US healthcare costs. The nationwide burden of 30\u2010day readmissions after such events has not been comprehensively assessed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      We analyzed adults \u226518\u00a0years of age with hospitalizations associated with acute\n                      <jats:styled-content style=\"fixed-case\">VTE<\/jats:styled-content>\n                      between January 1, 2010, and December 31, 2014, in the Nationwide Readmissions Database.\n                      <jats:italic>International Classification of Disease, Ninth Revision, Clinical Modification<\/jats:italic>\n                      (\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>\n                        \u20109\u2010\n                      <\/jats:italic>\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>CM<\/jats:italic>\n                        )\n                      <\/jats:styled-content>\n                      codes were used to identify hospitalizations associated with acute pulmonary embolism or deep vein thrombosis. The primary outcome was the rate of unplanned 30\u2010day readmission. Hierarchical logistic regression was used to calculate hospital\u2010specific 30\u2010day risk\u2010standardized readmission rates, a marker of healthcare quality. Among 1\u00a0176\u00a0335 hospitalizations with acute\n                      <jats:styled-content style=\"fixed-case\">VTE<\/jats:styled-content>\n                      , in\u2010hospital death occurred in 6.2%.\n                      <jats:styled-content style=\"fixed-case\">VTE<\/jats:styled-content>\n                      was associated with malignancy in 19.7%, recent surgery in 19.3%, recent trauma in 4.6%, hypercoagulability in 3.3%, and pregnancy in 1.0%. Among survivors to discharge, the 30\u2010day readmission rate was 17.5%, with no significant difference in rates across study years (17.4%\u201317.7%;\n                      <jats:italic>P<\/jats:italic>\n                      =0.10 for trend). Major predictors of readmission were malignancy (relative risk, 1.49, 95% confidence interval 1.47\u20101.50), Medicaid insurance (relative risk, 1.48, 95% confidence interval 1.46\u20101.50), and nonelective index admission (relative risk, 1.31, 95% confidence interval 1.29\u20101.33). Top causes of readmission included sepsis (9.6%) and procedural complications (8.1%). Median rehospitalization costs were $9781.7 (interquartile range, $5430.7\u2013$18\u00a0784.1), and 8.1% died during readmission. The interquartile range in risk\u2010standardized readmission rates was 16.6% to 18.3%, suggesting modest interhospital heterogeneity in readmission risk.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Nearly 1 in 5 patients with acute\n                      <jats:styled-content style=\"fixed-case\">VTE<\/jats:styled-content>\n                      were readmitted within 30\u00a0days. Predictors and causes of readmission were primarily related to patient characteristics and complications from comorbid conditions, whereas healthcare quality had a moderate impact on readmission risk.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.118.009047","type":"journal-article","created":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T05:15:29Z","timestamp":1529990129000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":39,"title":["High Burden of 30\u2010Day Readmissions After Acute Venous Thromboembolism in the United States"],"prefix":"10.1161","volume":"7","author":[{"given":"Eric A.","family":"Secemsky","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Medicine Massachusetts General Hospital Boston MA"},{"name":"Harvard Medical School Boston MA"},{"name":"Department of Medicine Smith Center for Outcomes Research in Cardiology Beth Israel Deaconess Medical Center Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Rosenfield","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Massachusetts General Hospital Boston MA"},{"name":"Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin F.","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Saint Luke's Mid\u2010America Heart Institute Kansas City MO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Jaff","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Medicine Massachusetts General Hospital Boston MA"},{"name":"Harvard Medical School Boston MA"},{"name":"Newton\u2010Wellesley Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Yeh","sequence":"additional","affiliation":[{"name":"Harvard Medical School Boston MA"},{"name":"Department of Medicine Smith Center for Outcomes Research in Cardiology Beth Israel Deaconess Medical Center Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.304488"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2015.10.014"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.158.6.585"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1549-3741(04)30058-4"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2015.11.033"},{"key":"e_1_3_2_7_2","unstructured":"The Surgeon General's Call to Action to Prevent Deep Vein Thrombosis and Pulmonary Embolism [Internet]. www.surgeongeneral.gov\/topics\/deepvein\/calltoaction\/call-to-action-on-dvt-2008.pdf. Accessed June 8 2017."},{"key":"e_1_3_2_8_2","unstructured":"Medicare and Medicaid Move Aggressively to Encourage Greater Patient Safety in Hospitals and Reduce Never Events [Internet]. https:\/\/www.cms.gov\/Newsroom\/MediaReleaseDatabase\/Press-releases\/2008-Press-releases-items\/2008-07-313.html. Accessed June 8 2017."},{"key":"e_1_3_2_9_2","unstructured":"Centers for Medicare and Medicaid Services . Readmissions Reduction Program [Internet]. https:\/\/www.cms.gov\/medicare\/medicare-fee-for-service-payment\/acuteinpatientpps\/readmissions-reduction-program.html. Accessed March 31 2017."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1201268"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-014-3087-3"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.7326\/M16-0185"},{"key":"e_1_3_2_13_2","unstructured":"HCUP Database Online Ordering [Internet]. https:\/\/www.distributor.hcup-us.ahrq.gov. 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