{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T02:36:05Z","timestamp":1784255765171,"version":"3.55.0"},"reference-count":56,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"23","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,12,4]]},"abstract":"\n Background<\/jats:title>\n \n The role of adipokine dysregulation in determining the metabolic fate of obesity is not well studied. We aimed to examine whether the matricellular protein osteonectin and the profiles of certain adipokines could differentiate metabolically healthy obese (\n MHO<\/jats:styled-content>\n ) versus metabolically unhealthy obese phenotypes in childhood.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n This study included 1137 obese children and 982 normal\u2010weight healthy (\n NWH<\/jats:styled-content>\n ) controls recruited from the BCAMS (Beijing Child and Adolescent Metabolic Syndrome) study.\n MHO<\/jats:styled-content>\n was defined by the absence of insulin resistance and\/or any metabolic syndrome components. Six adipokines\u2014osteonectin, leptin, adiponectin, resistin, FGF21 (fibroblast growth factor 21), and RBP\u20104 (retinol binding protein 4)\u2014were assessed. Approximately 20% of obese children displayed the\n MHO<\/jats:styled-content>\n phenotype.\n MHO<\/jats:styled-content>\n children had a more favorable adipokine profile than metabolically unhealthy obese children, with lower osteonectin, leptin, and\n RBP<\/jats:styled-content>\n \u20104 and higher adiponectin (all\n P<\/jats:italic>\n <0.05). Compared with normal\u2010weight healthy controls,\n MHO<\/jats:styled-content>\n children displayed increased leptin, resistin, and\n RBP<\/jats:styled-content>\n \u20104 levels and reduced adiponectin concentrations (all\n P<\/jats:italic>\n <0.05) but similar osteonectin and\n FGF<\/jats:styled-content>\n 21 levels. Among obese subjects, decreased osteonectin (odds ratio [OR]: 0.82; 95% confidence interval [CI] per standard deviation, 0.70\u20130.97),\n RBP<\/jats:styled-content>\n \u20104 (OR: 0.77; 95% CI per standard deviation, 0.64\u20130.93), and leptin\/adiponectin ratio (OR: 0.58; 95% CI per standard deviation, 0.43\u20130.77) were independent predictors of\n MHO<\/jats:styled-content>\n . In addition, compared with children without abnormalities, those with any 3 adipokine abnormalities were 80% less likely to exhibit the\n MHO<\/jats:styled-content>\n phenotype (\n OR<\/jats:styled-content>\n : 0.20; 95%\n CI<\/jats:styled-content>\n , 0.10\u20130.43) and 3 times more likely to have metabolic syndrome (\n OR<\/jats:styled-content>\n : 2.77; 95%\n CI<\/jats:styled-content>\n , 1.52\u20135.03).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n These findings suggest that dysregulation of adipokines might govern the metabolic consequences of obesity in children. Low osteonectin levels, along with a healthy adipokine profile, might be used as an early marker of the\n MHO<\/jats:styled-content>\n phenotype.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.118.009169","type":"journal-article","created":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T17:05:47Z","timestamp":1543943147000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":33,"title":["Circulating Osteonectin and Adipokine Profiles in Relation to Metabolically Healthy Obesity in Chinese Children: Findings From BCAMS"],"prefix":"10.1161","volume":"7","author":[{"given":"Junling","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Endocrinology NHC Key Laboratory of Endocrinology Peking Union Medical College Hospital Chinese Academy of Medical Science Beijing China"},{"name":"Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology NHC Key Laboratory of Endocrinology Peking Union Medical College Hospital Chinese Academy of Medical Science Beijing China"},{"name":"Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Issy C.","family":"Esangbedo","sequence":"additional","affiliation":[{"name":"Health Weight Program The Children's Hospital of Philadelphia Perelman School of Medicine at University of Pennsylvania Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology NHC Key Laboratory of Endocrinology Peking Union Medical College Hospital Chinese Academy of Medical Science Beijing China"},{"name":"Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Beijing Chaoyang Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lujiao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology NHC Key Laboratory of Endocrinology Peking Union Medical College Hospital Chinese Academy of Medical Science Beijing China"},{"name":"Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology NHC Key Laboratory of Endocrinology Peking Union Medical College Hospital Chinese Academy of Medical Science Beijing China"},{"name":"Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanwen","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Beijing Chaoyang Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyao","family":"Li","sequence":"additional","affiliation":[{"name":"Departments of Biostatistics and Epidemiology University of Pennsylvania Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhong","family":"Li","sequence":"additional","affiliation":[{"name":"Departments of Endocrinology\/Diabetes The Children's Hospital of Philadelphia Perelman School of Medicine University of Pennsylvania Philadelphia PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Beijing Chaoyang Hospital Capital Medical University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology NHC Key Laboratory of Endocrinology Peking Union Medical College Hospital Chinese Academy of Medical Science Beijing China"},{"name":"Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven. 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