{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T17:20:58Z","timestamp":1764350458704,"version":"3.41.2"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,8,21]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Visceral adipose tissue (\n              <jats:styled-content style=\"fixed-case\">VAT<\/jats:styled-content>\n              ) and other measures of central obesity predict incident atherosclerotic cardiovascular disease (\n              <jats:styled-content style=\"fixed-case\">ASCVD<\/jats:styled-content>\n              ) events in middle\u2010aged individuals, but these associations are less certain in older individuals age 70 years and older. Our objective was to estimate the associations of\n              <jats:styled-content style=\"fixed-case\">VAT<\/jats:styled-content>\n              and the android\u2013gynoid fat mass ratio, another measure of central obesity, with incident\n              <jats:styled-content style=\"fixed-case\">ASCVD<\/jats:styled-content>\n              events among a large cohort of older men.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Two thousand eight hundred ninety\u2010nine men (mean [\n              <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n              ] age 76.3 [5.5] years) enrolled in the Outcomes of Sleep Disorders in Older Men study had rigorous adjudication of incident\n              <jats:styled-content style=\"fixed-case\">ASCVD<\/jats:styled-content>\n              events (myocardial infarction, coronary heart disease death, or fatal or nonfatal stroke). We used proportional hazards models to estimate the hazard ratios for incident\n              <jats:styled-content style=\"fixed-case\">ASCVD<\/jats:styled-content>\n              per\n              <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n              increase of\n              <jats:styled-content style=\"fixed-case\">VAT<\/jats:styled-content>\n              or android\u2013gynoid fat mass ratio (measured at baseline with dual\u2010energy absorptiometry), adjusted for age, race, education, systolic blood pressure, smoking status, oxidized low\u2010density lipoprotein level, treatment for hypertension, statin use, aspirin use, presence of diabetes mellitus, and study enrollment site. Over a mean (\n              <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n              ) follow\u2010up period of 7.9 (3.4) years, 424 men (14.6%) had an incident\n              <jats:styled-content style=\"fixed-case\">ASCVD<\/jats:styled-content>\n              event. Neither\n              <jats:styled-content style=\"fixed-case\">VAT<\/jats:styled-content>\n              nor android\u2013gynoid fat mass ratio were associated with incident\n              <jats:styled-content style=\"fixed-case\">ASCVD<\/jats:styled-content>\n              events, either unadjusted or after multivariable\u2010adjustment (hazard ratios [95% confidence interval ] per\n              <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n              increase 1.02 [0.92\u20131.13] and 1.05 [0.95\u20131.17], respectively).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Central adipose tissue, as measured by\n              <jats:styled-content style=\"fixed-case\">VAT<\/jats:styled-content>\n              or android\u2013gynoid fat mass ratio, was not associated with incident\n              <jats:styled-content style=\"fixed-case\">ASCVD<\/jats:styled-content>\n              events in this study of older men.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.118.009172","type":"journal-article","created":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T20:16:46Z","timestamp":1536956206000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":25,"title":["Central Obesity and Visceral Adipose Tissue Are Not Associated With Incident Atherosclerotic Cardiovascular Disease Events in Older Men"],"prefix":"10.1161","volume":"7","author":[{"given":"John T.","family":"Schousboe","sequence":"first","affiliation":[{"name":"Park Nicollet Clinic &amp; HealthPartners Institute Minneapolis MN"},{"name":"University of Minnesota Minneapolis MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allyson M.","family":"Kats","sequence":"additional","affiliation":[{"name":"University of Minnesota Minneapolis MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Langsetmo","sequence":"additional","affiliation":[{"name":"University of Minnesota Minneapolis MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tien N.","family":"Vo","sequence":"additional","affiliation":[{"name":"University of Minnesota Minneapolis MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brent C.","family":"Taylor","sequence":"additional","affiliation":[{"name":"University of Minnesota Minneapolis MN"},{"name":"VA Health Care System Minneapolis MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann V.","family":"Schwartz","sequence":"additional","affiliation":[{"name":"University of California San Francisco CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peggy M.","family":"Cawthon","sequence":"additional","affiliation":[{"name":"California Pacific Medical Center Research Institute San Francisco CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cora E.","family":"Lewis","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham AL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Barrett\u2010Connor","sequence":"additional","affiliation":[{"name":"University of California San Diego CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew R.","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Stanford University Stanford CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric S.","family":"Orwoll","sequence":"additional","affiliation":[{"name":"Oregon Health &amp; Sciences University Portland OR"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristine E.","family":"Ensrud","sequence":"additional","affiliation":[{"name":"University of Minnesota Minneapolis MN"},{"name":"VA Health Care System Minneapolis MN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the Osteoporotic Fractures in Men (MrOS) Study Research Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","first-page":"537","article-title":"Body composition assessment for the definition of cardiometabolic risk","volume":"36","author":"Amato MC","year":"2013","unstructured":"Amato MC, Guarnotta V, Giordano C. 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