{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T13:39:43Z","timestamp":1787578783458,"version":"build-2736575974"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,10,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Regulator of G protein signaling 6 (\n              <jats:styled-content style=\"fixed-case\">RGS<\/jats:styled-content>\n              6) is an important member of the\n              <jats:styled-content style=\"fixed-case\">RGS<\/jats:styled-content>\n              family and produces pleiotropic regulatory effects on cardiac pathophysiology. However, the role of\n              <jats:styled-content style=\"fixed-case\">RGS<\/jats:styled-content>\n              6 protein in cardiomyocytes during angiotensin\n              <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\n              \u2013 and pressure overload\u2013induced cardiac hypertrophy remain unknown.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Here, we used a genetic approach to study the regulatory role of\n              <jats:styled-content style=\"fixed-case\">RGS<\/jats:styled-content>\n              6 in cardiomyocytes during pathological cardiac hypertrophy.\n              <jats:styled-content style=\"fixed-case\">RGS<\/jats:styled-content>\n              6 expression was significantly increased in failing human hearts and in hypertrophic murine hearts. The extent of aortic banding\u2013induced cardiac hypertrophy, dysfunction, and fibrosis in cardiac\u2010specific\n              <jats:styled-content style=\"fixed-case\">RGS<\/jats:styled-content>\n              6 knockout mice was alleviated, whereas the hearts of transgenic mice with cardiac\u2010specific\n              <jats:styled-content style=\"fixed-case\">RGS<\/jats:styled-content>\n              6 overexpression exhibited exacerbated responses to pressure overload. Consistent with these findings,\n              <jats:styled-content style=\"fixed-case\">RGS<\/jats:styled-content>\n              6 also facilitated an angiotensin\n              <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\n              \u2013induced hypertrophic response in isolated cardiomyocytes. According to the mechanistic studies,\n              <jats:styled-content style=\"fixed-case\">RGS<\/jats:styled-content>\n              6 mediated cardiac hypertrophy by directly interacting with apoptosis signal\u2013regulating kinase 1, which further activates the P38\u2010c\u2010\n              <jats:styled-content style=\"fixed-case\">JUN<\/jats:styled-content>\n              N\u2010terminal kinase 1\/2 signaling pathway.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Based on our findings,\n              <jats:styled-content style=\"fixed-case\">RGS<\/jats:styled-content>\n              6 aggravates cardiac hypertrophy, and the\n              <jats:styled-content style=\"fixed-case\">RGS<\/jats:styled-content>\n              6\u2010apoptosis signal\u2013regulating kinase 1 pathway represents a potential therapeutic target to attenuate pressure overload\u2013driven cardiac remodeling.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.118.009179","type":"journal-article","created":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T09:00:44Z","timestamp":1537866044000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Regulator of G Protein Signaling 6 Facilities Cardiac Hypertrophy by Activating Apoptosis Signal\u2013Regulating Kinase 1\u2013P38\/c\u2010JUN N\u2010Terminal Kinase 1\/2 Signaling"],"prefix":"10.1161","volume":"7","author":[{"given":"Zhijun","family":"Huang","sequence":"first","affiliation":[{"name":"The Center of Clinical Pharmacology The Third Xiangya Hospital Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxian","family":"Shu","sequence":"additional","affiliation":[{"name":"The Center of Clinical Pharmacology The Third Xiangya Hospital Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Third Xiangya Hospital Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengqing","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Third Xiangya Hospital Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Lu","sequence":"additional","affiliation":[{"name":"The Center of Clinical Pharmacology The Third Xiangya Hospital Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijiang","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Third Xiangya Hospital Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nana","family":"Xu","sequence":"additional","affiliation":[{"name":"The Center of Clinical Pharmacology The Third Xiangya Hospital Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Yuan","sequence":"additional","affiliation":[{"name":"The Center of Clinical Pharmacology The Third Xiangya Hospital Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Third Xiangya Hospital Central South University Changsha China"},{"name":"The Center of Clinical Pharmacology The Third Xiangya Hospital Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31829e8776"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2011.172"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000120390.68287.BB"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.732990"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-009-9052-9"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-016-0566-1"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.06877"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.05957"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.24741"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.116.238345"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.224220"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-3453"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1418795112"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(00)00076-6"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/1478-811X-7-9"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.186700"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.69.1.795"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80117-8"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-016-9899-9"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-20-08024.1997"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.11.6489"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.224212"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2012.00095"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-3397"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2136717100"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/hc0402.102863"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu004"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00601.2014"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.135392"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.710434"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.200741"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2006.8.1729"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200420317"},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbior.2017.05.004"},{"key":"e_1_3_1_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4334"},{"key":"e_1_3_1_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4453"},{"key":"e_1_3_1_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.10080"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.118.009179","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:16:10Z","timestamp":1715598970000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.118.009179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,2]]},"references-count":37,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2018,10,2]]}},"alternative-id":["10.1161\/JAHA.118.009179"],"URL":"https:\/\/doi.org\/10.1161\/jaha.118.009179","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,2]]},"assertion":[{"value":"2018-06-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e009179"}}