{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T06:31:04Z","timestamp":1793169064556,"version":"4.5.0"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,8,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Atrial fibrillation (\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              ) is associated with myocardial infarction, and patients with\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              and no obstructive coronary artery disease can present with symptoms and evidence of cardiac ischemia. We hypothesized that microvascular coronary dysfunction underlies these observations.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Myocardial blood flow (\n              <jats:styled-content style=\"fixed-case\">MBF<\/jats:styled-content>\n              ) at baseline and during adenosine stress and left ventricular and left atrial function were evaluated by magnetic resonance in 49 patients with\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              (25 paroxysmal, 24 persistent) with no history of epicardial coronary artery disease or diabetes mellitus, before and 6 to 9\u00a0months after ablation. Findings were compared with those obtained in matched controls in sinus rhythm (n=25). Before ablation, patients with\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              had impaired left atrial function and left ventricular ejection fraction and strain indices (all\n              <jats:italic>P<\/jats:italic>\n              &lt;0.05 versus controls).\n              <jats:styled-content style=\"fixed-case\">MBF<\/jats:styled-content>\n              was impaired in patients both under baseline conditions (1.21\u00b10.24\u00a0mL\/min per g\u00b7[mm\u00a0Hg\u00b7bpm\/10\n              <jats:sup>4<\/jats:sup>\n              ]\n              <jats:sup>\u22121<\/jats:sup>\n              versus 1.34\u00b10.28\u00a0mL\/min per g\u00b7[mm\u00a0Hg\u00b7bpm\/10\n              <jats:sup>4<\/jats:sup>\n              ]\n              <jats:sup>\u22121<\/jats:sup>\n              in controls,\n              <jats:italic>P<\/jats:italic>\n              =0.044) and during adenosine stress (2.29\u00b10.48\u00a0mL\/min\u00a0per\u00a0g versus 2.73\u00b10.37\u00a0mL\/min\u00a0per\u00a0g in controls,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). Under baseline conditions,\n              <jats:styled-content style=\"fixed-case\">MBF<\/jats:styled-content>\n              correlated with left ventricular strain and left atrial function (all\n              <jats:italic>P<\/jats:italic>\n              \u22640.001), so that cardiac function was most impaired in patients with the lowest\n              <jats:styled-content style=\"fixed-case\">MBF<\/jats:styled-content>\n              . Baseline and stress\n              <jats:styled-content style=\"fixed-case\">MBF<\/jats:styled-content>\n              remained unchanged postablation (both\n              <jats:italic>P<\/jats:italic>\n              =ns), and baseline\n              <jats:styled-content style=\"fixed-case\">MBF<\/jats:styled-content>\n              showed similar correlations with functional indices to those present preablation (all\n              <jats:italic>P<\/jats:italic>\n              \u22640.001).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Baseline and stress\n              <jats:styled-content style=\"fixed-case\">MBF<\/jats:styled-content>\n              are significantly impaired in patients with\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              but no epicardial coronary artery disease. Reduction in\n              <jats:styled-content style=\"fixed-case\">MBF<\/jats:styled-content>\n              is proportional to severity of left ventricular and left atrial dysfunction, even after successful ablation. Coronary microvascular dysfunction may be a relevant pathophysiological mechanism in patients with a history of\n              <jats:styled-content style=\"fixed-case\">AF<\/jats:styled-content>\n              .\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.118.009218","type":"journal-article","created":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T06:43:15Z","timestamp":1537080195000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":41,"title":["Myocardial Perfusion Is Impaired and Relates to Cardiac Dysfunction in Patients With Atrial Fibrillation Both Before and After Successful Catheter Ablation"],"prefix":"10.1161","volume":"7","author":[{"given":"Rohan S.","family":"Wijesurendra","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine University of Oxford Oxford United Kingdom"},{"name":"University of Oxford Centre for Clinical Magnetic Resonance Research Oxford United Kingdom"},{"name":"Oxford Heart Centre Oxford University Hospitals NHS Foundation Trust Oxford United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of Oxford Oxford United Kingdom"},{"name":"University of Oxford Centre for Clinical Magnetic Resonance Research Oxford United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Notaristefano","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of Oxford Oxford United Kingdom"},{"name":"University of Oxford Centre for Clinical Magnetic Resonance Research Oxford United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ntobeko A. B.","family":"Ntusi","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of Oxford Oxford United Kingdom"},{"name":"University of Oxford Centre for Clinical Magnetic Resonance Research Oxford United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodoros D.","family":"Karamitsos","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of Oxford Oxford United Kingdom"},{"name":"University of Oxford Centre for Clinical Magnetic Resonance Research Oxford United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaver","family":"Bashir","sequence":"additional","affiliation":[{"name":"Oxford Heart Centre Oxford University Hospitals NHS Foundation Trust Oxford United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Ginks","sequence":"additional","affiliation":[{"name":"Oxford Heart Centre Oxford University Hospitals NHS Foundation Trust Oxford United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Rajappan","sequence":"additional","affiliation":[{"name":"Oxford Heart Centre Oxford University Hospitals NHS Foundation Trust Oxford United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim R.","family":"Betts","sequence":"additional","affiliation":[{"name":"Oxford Heart Centre Oxford University Hospitals NHS Foundation Trust Oxford United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Jerosch\u2010Herold","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa M.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of Oxford Oxford United Kingdom"},{"name":"University of Oxford Centre for Clinical Magnetic 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