{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:39:02Z","timestamp":1753889942499,"version":"3.41.2"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,7,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Newer implantable cardioverter defibrillators can monitor intracardiac ECGs , but their ability to detect ischemia is unclear. This study investigated the usefulness of implantable cardioverter defibrillators with an ST\u2010monitoring function in coronary artery disease patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We conducted a prospective study of implantable cardioverter defibrillator patients with the ST\u2010monitoring function. One hundred seventy\u2010three patients who received implantable cardioverter defibrillators for primary or secondary prevention of sudden cardiac death. All patients underwent medical examinations at least every 6\u00a0months, with standard 12\u2010lead ECGs and device checks that included analysis of the ST\u2010monitoring function. Myocardial perfusion imaging or coronary angiography was performed during the follow\u2010up. The mean follow\u2010up duration was 23.3\u00b17.7\u00a0months. Significant ST changes occurred in 15 patients (8.7%), of whom 14 were asymptomatic. The incidence of angina pectoris was significantly higher in the ST change (+) group than that in the ST change (\u2212) group (28.6% versus 7.2%,\n              <jats:italic>P<\/jats:italic>\n              =0.03). In the patients who underwent myocardial perfusion imaging, the sensitivity, specificity, and negative predictive value of the ST\u2010monitoring feature to detect ischemia were 75.0%, 72.5%, and 93.5%, respectively. The sensitivity, specificity, and negative predictive value of the ST\u2010monitoring feature to predict residual stenosis evaluated using coronary angiography were 76.9%, 83.5%, and 97.5%, respectively. The percentage of patients with a septal right ventricular lead was significantly lower in the ST change (+) group than in the ST change (\u2212) group (13.5% versus 33.5%,\n              <jats:italic>P<\/jats:italic>\n              =0.01).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">If intracardiac ECGs ST changes are detected, it is necessary to use additional modalities even in asymptomatic patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Clinical Trial Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/upload.umin.ac.jp\">upload.umin.ac.jp<\/jats:ext-link>\n              . Unique identifier: UMIN000011824.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.118.009332","type":"journal-article","created":{"date-parts":[[2018,6,30]],"date-time":"2018-06-30T09:15:10Z","timestamp":1530350110000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Continuous ST\u2010Monitoring Function of Implantable Cardioverter Defibrillator Detects Silent Ischemia in Patients With Coronary Artery Disease"],"prefix":"10.1161","volume":"7","author":[{"given":"Tetsuya","family":"Watanabe","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Yao Municipal Hospital Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Hirooka","sequence":"additional","affiliation":[{"name":"Cardiovascular Division Osaka National Hospital Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Division of Cardiology Osaka General Medical Center Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Yabuki","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Higashi Takarazuka Satoh Hospital Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akio","family":"Hirata","sequence":"additional","affiliation":[{"name":"Cardiovascular Division Osaka Police Hospital Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunori","family":"Kashiwase","sequence":"additional","affiliation":[{"name":"Cardiovascular Division Osaka Police Hospital Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryu","family":"Shutta","sequence":"additional","affiliation":[{"name":"Division of Cardiology Osaka Rosai Hospital Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanao","family":"Mine","sequence":"additional","affiliation":[{"name":"Cardiovascular Division Department of Internal Medicine Hyogo College of Medicine Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroya","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Department of Advanced Cardiovascular Therapeutics Osaka University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshikazu","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Cardiology Okazaki City Hospital Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Doi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Graduate School of Medicine Kyoto University Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Department of Internal Medicine Kobe University Graduate School of Medicine Hyogo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Okuyama","sequence":"additional","affiliation":[{"name":"Department of Advanced Cardiovascular Therapeutics Osaka University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinsuke","family":"Nanto","sequence":"additional","affiliation":[{"name":"Department of Advanced Cardiovascular Therapeutics Osaka University Graduate School of Medicine Osaka 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