{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T03:02:27Z","timestamp":1768532547086,"version":"3.49.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,10,2]]},"abstract":"\n Background<\/jats:title>\n \n Previous studies have provided conflicting results as to whether women are at higher risk than men for thromboembolism in the setting of atrial fibrillation (\n AF<\/jats:styled-content>\n ). We investigated whether women with\n AF<\/jats:styled-content>\n were at higher risk of ischemic stroke in the China\u2010AF (China Atrial Fibrillation Registry) Study.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n A total of 19\u00a0515 patients were prospectively enrolled between August 2011 and December 2016 in the China\u2010\n AF<\/jats:styled-content>\n Study. After exclusion of patients receiving anticoagulation or ablation therapy, 6239 patients (2574 women) with results from at least 6\u00a0months of follow\u2010up were used for the analysis. Cox proportional hazards models were performed to evaluate whether female sex was an independent risk factor for thromboembolism after multivariate adjustment. The primary outcome was the time to the first occurrence of ischemic stroke or systemic embolism. After a mean follow\u2010up of 2.81\u00b11.46\u00a0years, 152 female patients reached the primary outcome, as compared with 172 male patients. Crude incidence rates of thromboembolism between women and men were of borderline statistical significance (2.08 versus 1.68 per 100\u00a0patient\u2010years,\n P<\/jats:italic>\n =0.058). After multivariable analysis, female sex was not independently associated with an increased thromboembolism risk (hazard ratio 1.09, 95% confidence interval 0.86\u20101.39). There was no significant difference in thromboembolism risk by sex stratified by age and presence or absence of risk factors (\n P<\/jats:italic>\n for interaction all >0.1).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Although crude incidence rates of thromboembolism were higher in Chinese female patients with\n AF<\/jats:styled-content>\n compared with male patients, female sex did not emerge as an independent risk factor for thromboembolism on multivariate analysis.\n <\/jats:p>\n <\/jats:sec>\n \n Clinical Trial Registration<\/jats:title>\n \n URL<\/jats:styled-content>\n :\n http:\/\/www.chictr.org.cn\/<\/jats:ext-link>\n . Unique identifier: Chi\n CTR<\/jats:styled-content>\n \u2010\n OCH<\/jats:styled-content>\n \u201013003729.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.118.009391","type":"journal-article","created":{"date-parts":[[2018,9,26]],"date-time":"2018-09-26T09:01:02Z","timestamp":1537952462000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Female Sex as a Risk Factor for Ischemic Stroke and Systemic Embolism in Chinese Patients With Atrial Fibrillation: A Report From the China\u2010AF Study"],"prefix":"10.1161","volume":"7","author":[{"given":"Di\u2010Hui","family":"Lan","sequence":"first","affiliation":[{"name":"Department of Cardiology Heart Center Zhu Jiang Hospital Southern Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Beijing AnZhen Hospital Capital Medical 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