{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T04:05:19Z","timestamp":1754193919553,"version":"3.41.2"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,10,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Ticagrelor use during acute coronary syndromes demonstrated a decrease in all\u2010cause mortality in the\n              <jats:styled-content style=\"fixed-case\">PLATO<\/jats:styled-content>\n              (Platelet Inhibition and Patient Outcomes) trial. This effect has been attributed to a non\u2013platelet\u2010derived improvement in endothelial function. The aim of this study was to determine differences in the number of endothelial progenitor cells and\/or circulating endothelial cells found in peripheral blood in patients treated with either ticagrelor or clopidogrel during non\u2013ST\u2010segment\u2013elevation myocardial infarction.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In this multicenter, randomized study (\n              <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>\n              02244710), patients were considered for inclusion after non\u2013ST\u2010segment\u2013elevation myocardial infarction whenever they were P2Y\n              <jats:sub>12<\/jats:sub>\n              \u2010inhibitor na\u00efve. Ticagrelor and clopidogrel were allocated at a 1:1 ratio. Blood samples for determining endothelial progenitor cells and circulating endothelial cells were extracted before the antiplatelet loading dose, 48\u00a0hours after presentation of index symptoms, and 1\u00a0month after the event. A multichannel cytometer was used for optimal cell characterization. A total of 96 patients fulfilled the inclusion criteria. Circulating endothelial cell levels corrected by white blood cells were as follows at baseline, 48\u00a0hours, and 1\u00a0month: 44 (28\u201364), 50 (33\u201363), and 38 (23\u201362) cells\/mL, respectively, for clopidogrel and 38 (29\u201360), 45 (32\u201385), and 35 (24\u201371) cells\/mL, respectively, for ticagrelor (\n              <jats:italic>P<\/jats:italic>\n              =0.6). Endothelial progenitor cell levels were 29 (15\u201347), 27 (15\u201333), and 18 (10\u201325) cells\/mL, respectively, for clopidogrel and 20 (11\u201333), 22 (12\u201332), and 18 (11\u201329) cells\/mL, respectively, for ticagrelor (\n              <jats:italic>P<\/jats:italic>\n              =0.9). No differences in intraindividual changes were found.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Patients treated with ticagrelor during non\u2013ST\u2010segment\u2013elevation myocardial infarction, in comparison to clopidogrel, showed similar levels of endothelial progenitor cells and circulating endothelial cells. These data suggest that the endothelial protective effect mediated by ticagrelor is not related to bone marrow physiology modulation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Clinical Trial Registration<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              URL:\n              <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n              . Unique identifier:\n              <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>\n              02244710.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.118.009444","type":"journal-article","created":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T09:00:48Z","timestamp":1537434048000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["No Differences in Levels of Circulating Progenitor Endothelial Cells or Circulating Endothelial Cells Among Patients Treated With Ticagrelor Compared With Clopidogrel During Non\u2013ST\u2010Segment\u2013Elevation Myocardial Infarction"],"prefix":"10.1161","volume":"7","author":[{"given":"Alejandro","family":"Diego\u2010Nieto","sequence":"first","affiliation":[{"name":"Department of Cardiology University Hospital of Salamanca"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria B.","family":"Vidriales","sequence":"additional","affiliation":[{"name":"Department of Haematology University Hospital of Salamanca"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norberto","family":"Alonso\u2010Orcajo","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital of Le\u00f3n"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose C.","family":"Moreno\u2010Samos","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital of Salamanca"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Martin\u2010Herrero","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital of Salamanca"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raul","family":"Carbonell","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital of Le\u00f3n"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belen","family":"Cid","sequence":"additional","affiliation":[{"name":"Department of Cardiology City of Universitu Hospital of Santiago de Compostela"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Cruz\u2010Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital of Salamanca"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier C.","family":"Martin\u2010Moreiras","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital of Salamanca"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Cuellas","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital of Le\u00f3n"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Pascual","sequence":"additional","affiliation":[{"name":"Department 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