{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:29:25Z","timestamp":1778621365809,"version":"3.51.4"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"24","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,12,18]]},"abstract":"\n Background<\/jats:title>\n \n Evidence suggests that patients with higher blood pressure variability (\n BPV<\/jats:styled-content>\n ) have a higher risk for stroke, but any link between\n BPV<\/jats:styled-content>\n and stroke recurrence is unknown among those who had a stroke or transient ischemic attack (\n TIA<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Data for patients with a history of stroke or\n TIA<\/jats:styled-content>\n at enrollment were extracted from the\n ASCOT<\/jats:styled-content>\n (Anglo Scandinavian Cardiac Outcomes Trial) and the\n ALLHAT<\/jats:styled-content>\n (Antihypertensive and Lipid\u2010Lowering Treatment to Prevent Heart Attack Trial).\n BPV<\/jats:styled-content>\n was defined as the within\u2010subject standard deviation or coefficient of variation of systolic blood pressure across visits from 12\u00a0weeks poststroke or\n TIA<\/jats:styled-content>\n onward.\n BPV<\/jats:styled-content>\n was significantly higher in patients with a history of stroke or\n TIA<\/jats:styled-content>\n than those without. BPV was a predictor of recurrent stroke in the pooled analysis. In the\n ASCOT<\/jats:styled-content>\n study, 252 patients (12.3%) had a recurrent stroke among 2046 with a history of stroke. Incidence of recurrent stroke was significantly higher in the highest BPV quartile (17.8%) compared with the lowest quartile (10.5%); by treatment arm, this reached significance for the amlodipine\u2010arm only (high\u2010\n BPV<\/jats:styled-content>\n : 18.7% versus low\u2010\n BPV<\/jats:styled-content>\n : 12.9%;\n P<\/jats:italic>\n =0.029). Of the 2173 patients from the\n ALLHAT<\/jats:styled-content>\n with a history of stroke or\n TIA<\/jats:styled-content>\n , patients with the highest quartile of\n BPV<\/jats:styled-content>\n had a higher incidence of recurrent stroke (9.6%) compared with the lowest quartile BPV (5.5%); by treatment arm, this reached significance for the chlorthalidone\u2010arm only (high\u2010\n BPV<\/jats:styled-content>\n : 12.1% versus low\u2010\n BPV<\/jats:styled-content>\n : 5.4%;\n P<\/jats:italic>\n =0.007).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Visit\u2010to\u2010visit\n BPV<\/jats:styled-content>\n is a predictor of recurrent stroke in patients with a history of stroke or\n TIA<\/jats:styled-content>\n on antihypertensive treatment. Considering\n BPV<\/jats:styled-content>\n following a stroke may be important to reduce the risk for a recurrent stroke.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.118.009480","type":"journal-article","created":{"date-parts":[[2018,12,7]],"date-time":"2018-12-07T10:00:47Z","timestamp":1544176847000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Relationship of Inter\u2010Individual Blood Pressure Variability and the Risk for Recurrent Stroke"],"prefix":"10.1161","volume":"7","author":[{"given":"Bum Joon","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Neurology Kyung Hee University Hospital Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun U.","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Neurology Asan Medical Center University of Ulsan College of Medicine Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalia","family":"Wajsbrot","sequence":"additional","affiliation":[{"name":"Pfizer Essential Health Pfizer New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaseong","family":"Koo","sequence":"additional","affiliation":[{"name":"Department of Neurology Catholic University of Korea Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Moo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology Eulji General Hospital Eulji University Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barrett W.","family":"Jeffers","sequence":"additional","affiliation":[{"name":"Pfizer Essential Health Pfizer New York NY"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2007.039545"},{"key":"e_1_3_2_3_2","first-page":"43","article-title":"Disorders of the autonomic nervous system after hemispheric cerebrovascular disorders: an update","volume":"8","author":"Al\u2010Qudah ZA","year":"2015","unstructured":"Al\u2010Qudah ZA, Yacoub HA, Souayah N. Disorders of the autonomic nervous system after hemispheric cerebrovascular disorders: an update. J Vasc Interv Neurol. 2015;8:43\u201352.","journal-title":"J Vasc Interv Neurol"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000160748.88374.ce"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60308-X"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jash.2016.08.004"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/jch.12484"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2015.04.011"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.113.01343"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.005982"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200312000-00012"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.005420"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpu070"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-013-0401-0"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.7326\/M14-2803"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1106"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpt167"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.23.2981"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67185-1"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200106000-00020"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.37.1.19"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70066-1"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31822b007a"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000675"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2014.09.149"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/jch.12290"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2006.07.017"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.118.009480","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:40:29Z","timestamp":1715600429000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.118.009480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,18]]},"references-count":26,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2018,12,18]]}},"alternative-id":["10.1161\/JAHA.118.009480"],"URL":"https:\/\/doi.org\/10.1161\/jaha.118.009480","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,18]]},"assertion":[{"value":"2018-05-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e009480"}}