{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:23:03Z","timestamp":1793380983535,"version":"4.5.0"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,7,17]]},"abstract":"\n Background<\/jats:title>\n \n Quantitative flow ratio (\n QFR<\/jats:styled-content>\n ) is a novel modality for physiological lesion assessment based on 3\u2010dimensional vessel reconstructions and contrast flow velocity estimates. We evaluated the value of online\n QFR<\/jats:styled-content>\n during routine invasive coronary angiography for procedural feasibility, diagnostic performance, and agreement with pressure\u2010wire\u2013derived fractional flow reserve (\n FFR<\/jats:styled-content>\n ) as a gold standard in an international multicenter study.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n FAVOR II<\/jats:styled-content>\n E\u2010J (Functional Assessment by Various Flow Reconstructions II Europe\u2010Japan) was a prospective, observational, investigator\u2010initiated study. Patients with stable angina pectoris were enrolled in 11 international centers.\n FFR<\/jats:styled-content>\n and online\n QFR<\/jats:styled-content>\n computation were performed in all eligible lesions. An independent core lab performed 2\u2010dimensional quantitative coronary angiography (2D\u2010\n QCA<\/jats:styled-content>\n ) analysis of all lesions assessed with\n QFR<\/jats:styled-content>\n and\n FFR<\/jats:styled-content>\n . The primary comparison was sensitivity and specificity of\n QFR<\/jats:styled-content>\n compared with 2D\u2010\n QCA<\/jats:styled-content>\n using\n FFR<\/jats:styled-content>\n as a reference standard. A total of 329 patients were enrolled. Paired assessment of\n FFR<\/jats:styled-content>\n ,\n QFR,<\/jats:styled-content>\n and 2D\u2010\n QCA<\/jats:styled-content>\n was available for 317 lesions. Mean\n FFR<\/jats:styled-content>\n ,\n QFR,<\/jats:styled-content>\n and percent diameter stenosis were 0.83\u00b10.09, 0.82\u00b110, and 45\u00b110%, respectively.\n FFR<\/jats:styled-content>\n was \u22640.80 in 104 (33%) lesions. Sensitivity and specificity by\n QFR<\/jats:styled-content>\n was significantly higher than by 2D\u2010\n QCA<\/jats:styled-content>\n (sensitivity, 86.5% (78.4\u201392.4) versus 44.2% (34.5\u201354.3);\n P<\/jats:italic>\n <0.001; specificity, 86.9% (81.6\u201391.1) versus 76.5% (70.3\u201382.0);\n P<\/jats:italic>\n =0.002). Area under the receiver curve was significantly higher for\n QFR<\/jats:styled-content>\n compared with 2D\u2010\n QCA<\/jats:styled-content>\n (\n area under the receiver curve,<\/jats:styled-content>\n 0.92 [0.89\u20130.96] versus 0.64 [0.57\u20130.70];\n P<\/jats:italic>\n <0.001). Median time to\n QFR<\/jats:styled-content>\n was significantly lower than median time to\n FFR<\/jats:styled-content>\n (time to\n QFR,<\/jats:styled-content>\n 5.0\u00a0minutes [\n interquartile range<\/jats:styled-content>\n , \u20136.1] versus time to\n FFR,<\/jats:styled-content>\n 7.0\u00a0minutes [\n interquartile range,<\/jats:styled-content>\n 5.0\u201310.0];\n P<\/jats:italic>\n <0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Online computation of\n QFR<\/jats:styled-content>\n in the catheterization laboratory is clinically feasible and is superior to angiographic assessment for evaluation of intermediary coronary artery stenosis using\n FFR<\/jats:styled-content>\n as a reference standard.\n <\/jats:p>\n <\/jats:sec>\n \n Clinical Trial Registration<\/jats:title>\n \n URL<\/jats:styled-content>\n :\n https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n . Unique identifier:\n NCT<\/jats:styled-content>\n 02959814.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.118.009603","type":"journal-article","created":{"date-parts":[[2018,7,6]],"date-time":"2018-07-06T05:21:29Z","timestamp":1530854489000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":352,"title":["Diagnostic Performance of In\u2010Procedure Angiography\u2010Derived Quantitative Flow Reserve Compared to Pressure\u2010Derived Fractional Flow Reserve: The FAVOR II Europe\u2010Japan Study"],"prefix":"10.1161","volume":"7","author":[{"given":"Jelmer","family":"Westra","sequence":"first","affiliation":[{"name":"Department of Cardiology Aarhus University Hospital Skejby Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitte Krogsgaard","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Aarhus University Hospital Skejby Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Campo","sequence":"additional","affiliation":[{"name":"Cardiovascular Institute Azienda Ospedaliero\u2010Universitaria di Ferrara Cona Italy"},{"name":"Maria Cecilia Hospital GVM Care and Research Cotignola (RA) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Gifu Heart Center Gifu City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukasz","family":"Koltowski","sequence":"additional","affiliation":[{"name":"Department of Cardiology Medical University of Warsaw Warszawa Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashkan","family":"Eftekhari","sequence":"additional","affiliation":[{"name":"Department of Cardiology Aarhus University Hospital Skejby 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H\u00f8j","family":"Christiansen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Aarhus University Hospital Skejby Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels Ramsing","family":"Holm","sequence":"additional","affiliation":[{"name":"Department of Cardiology Aarhus University Hospital Skejby 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