{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T14:53:04Z","timestamp":1785595984983,"version":"3.56.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,4,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The JROAD\u2010DPC (Japanese Registry of All Cardiac and Vascular Diseases Diagnosis Procedure Combination) is a nationwide claims database comprised of the Japanese\n              <jats:styled-content style=\"fixed-case\">DPC<\/jats:styled-content>\n              \/Per Diem Payment System. This study aimed to investigate the relationship between prescription rates of guideline\u2010directed medications in each hospital and in\u2010hospital mortality among patients with acute myocardial infarction.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              A total of 61\u00a0838 Japanese patients from 741 hospitals with acute myocardial infarction between 2012 and 2013 were enrolled. The relationship between prescription rates of 4 guideline\u2010directed medications for acute myocardial infarction and in\u2010hospital mortality was analyzed. There were variations in the prescription ratio of \u03b2\u2010blockers on admission (median prescription rate 23% [interquartile range 11% to 38%]) and at discharge (51% [36% to 63%]), and of angiotensin converting enzyme\/receptor blocker (60% [47% to 70%]). The highest prescription rate quartile of each medication was associated with a significantly lower mortality compared with the lowest prescription rate quartile (aspirin on admission, incidence rate ratio 0.67 [95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              0.61\u20100.74],\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001; aspirin at discharge, incidence rate ratio 0.50 [95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              0.46\u20100.55],\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001; \u03b2\u2010blocker on admission, 0.83 [0.76\u20100.92],\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001; \u03b2\u2010blocker at discharge, 0.78 [0.71\u20100.85],\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001; angiotensin converting enzyme\/receptor blocker, 0.68 [0.62\u20100.75],\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001; statin, 0.63 [0.57\u20100.70],\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001). The composite prescription score was inversely associated with in\u2010hospital mortality (\u03b2 coefficient=\u22120.48,\n              <jats:italic>P<\/jats:italic>\n              &lt;0.001) and was closer to the plateau in the high\u2010score range (median mortality for composite prescription scores of 6, 15, and 24 were 10.6%, 6.8%, and 4.6%, respectively).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">The prescription rates of guideline\u2010directed medications for treatment of Japanese acute myocardial infarction patients were inversely associated with in\u2010hospital mortality.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.118.009692","type":"journal-article","created":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T09:01:14Z","timestamp":1553590874000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Prescription Rates of Guideline\u2010Directed Medications Are Associated With In\u2010Hospital Mortality Among Japanese Patients With Acute Myocardial Infarction: A Report From JROAD\u2010DPC Study"],"prefix":"10.1161","volume":"8","author":[{"given":"Kazuhiro","family":"Nakao","sequence":"first","affiliation":[{"name":"National Cerebral and Cardiovascular Center Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Yasuda","sequence":"additional","affiliation":[{"name":"National Cerebral and Cardiovascular Center Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunihiro","family":"Nishimura","sequence":"additional","affiliation":[{"name":"National Cerebral and Cardiovascular Center Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruo","family":"Noguchi","sequence":"additional","affiliation":[{"name":"National Cerebral and Cardiovascular Center Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michikazu","family":"Nakai","sequence":"additional","affiliation":[{"name":"National Cerebral and Cardiovascular Center Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"National Cerebral and Cardiovascular Center Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Sumita","sequence":"additional","affiliation":[{"name":"National Cerebral and Cardiovascular Center Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Shishido","sequence":"additional","affiliation":[{"name":"National Cerebral and Cardiovascular Center Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihisa","family":"Anzai","sequence":"additional","affiliation":[{"name":"Hokkaido University Graduate School of Medicine Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ito","sequence":"additional","affiliation":[{"name":"Okayama University Medical School Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Tsutsui","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Faculty of Medical Sciences Kyushu University Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Saito","sequence":"additional","affiliation":[{"name":"Nara Medical University School of Medicine Kashihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Issei","family":"Komuro","sequence":"additional","affiliation":[{"name":"Graduate School of Medicine and Faculty of Medicine Tokyo University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisao","family":"Ogawa","sequence":"additional","affiliation":[{"name":"National Cerebral and Cardiovascular Center Suita Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00195-6"},{"key":"e_1_3_1_3_2","unstructured":"Ministry of Health Labour and Welfare . Statistics. 2015;2015."},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1178"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.01.014"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000133"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx393"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv320"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.191099"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/2048872616643053"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000435779.48007.5c"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2014.11.013"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-16-0196"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.035858"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-14-1214"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.46.855"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.011250"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.1.72"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx008"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62070-X"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-13-0174"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12928-012-0137-9"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-015-0791-9"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.16.1912"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.02.016"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2005.01.070"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h3913"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.21906"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005253422106"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa0907130"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.657601"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.22.2694"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2013.7049"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-154-6-201103150-00003"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.118.009692","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T11:43:18Z","timestamp":1715600598000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.118.009692"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,2]]},"references-count":33,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,4,2]]}},"alternative-id":["10.1161\/JAHA.118.009692"],"URL":"https:\/\/doi.org\/10.1161\/jaha.118.009692","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,2]]},"assertion":[{"value":"2018-08-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e009692"}}