{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:04:30Z","timestamp":1789704270225,"version":"4.0.1"},"reference-count":52,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"16","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,8,21]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Statins are commonly used for the prevention of cardiovascular events; however, statins are underutilized in patients with noncoronary atherosclerosis. We sought to establish the rates of statin use in patients with carotid artery disease and to examine the association between statin therapy and outcomes after carotid revascularization.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">In this population\u2010level retrospective cohort study, we identified all individuals aged \u226566\u00a0years who underwent carotid endarterectomy or stenting in Ontario, Canada (2002\u20132014). The primary outcome was a composite of 1\u2010year stroke, myocardial infarction, or death (major adverse cardiac and cerebrovascular events). Five\u2010year risks were also examined. Adjusted hazard ratios were computed using inverse probability of treatment weighting based on propensity scores. A total of 7893 of 10\u00a0723 patients (73.6%) who underwent carotid revascularization were on preprocedural statin therapy; moderate\u2010 or high\u2010dose therapy was utilized by 7384 patients (68.9%). The composite rate of 1\u2010year major adverse cardiac and cerebrovascular events was lower among statin users (adjusted hazard ratio: 0.76; 95% confidence interval, 0.70\u20130.83). Patients who were on persistent long\u2010term statin therapy after the carotid procedure continued to experience significantly lower risk of major adverse cardiac and cerebrovascular events at 5\u00a0years (adjusted hazard ratio: 0.75, 95% confidence interval, 0.71\u20130.80). The beneficial associations with statin use were observed regardless of type of carotid revascularization procedure, carotid artery symptom status, or statin\u00a0dose.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Continuous statin therapy was associated with a 25% lower risk of long\u2010term adverse cardiovascular events in patients with significant carotid disease. Along with other supportive evidence, statins should be considered in patients undergoing carotid revascularization, and efforts are required to increase statin use in this undertreated population.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.118.009745","type":"journal-article","created":{"date-parts":[[2018,9,14]],"date-time":"2018-09-14T20:16:46Z","timestamp":1536956206000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":37,"title":["Association Between Statin Use and Cardiovascular Events After Carotid Artery Revascularization"],"prefix":"10.1161","volume":"7","author":[{"given":"Mohamad A.","family":"Hussain","sequence":"first","affiliation":[{"name":"Division of Vascular Surgery St. Michael's Hospital Toronto Ontario Canada"},{"name":"Department of Surgery University of Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Saposnik","sequence":"additional","affiliation":[{"name":"Division of Neurology St. Michael's Hospital Toronto Ontario Canada"},{"name":"Li Ka Shing Knowledge Institute of St. Michael's Hospital Toronto Ontario Canada"},{"name":"Department of Medicine University of Toronto Ontario Canada"},{"name":"Institute of Health Policy, Management, and Evaluation University of Toronto Ontario Canada"},{"name":"Institute for Clinical Evaluative Sciences Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sneha","family":"Raju","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konrad","family":"Salata","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery St. Michael's Hospital Toronto Ontario Canada"},{"name":"Department of Surgery University of Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Mamdani","sequence":"additional","affiliation":[{"name":"Li Ka Shing Knowledge Institute of St. Michael's Hospital Toronto Ontario Canada"},{"name":"Institute of Health Policy, Management, and Evaluation University of Toronto Ontario Canada"},{"name":"Leslie Dan Faculty of Pharmacy University of Toronto Ontario Canada"},{"name":"Institute for Clinical Evaluative Sciences Toronto Ontario Canada"},{"name":"King Saud University\u2010Li Ka Shing Collaborative Research Program King Saud University Riyadh Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack V.","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Toronto Ontario Canada"},{"name":"Institute of Health Policy, Management, and Evaluation University of Toronto Ontario Canada"},{"name":"Institute for Clinical Evaluative Sciences Toronto Ontario Canada"},{"name":"Division of Cardiology Schulich Heart Centre Sunnybrook Health Sciences Centre Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak L.","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital Heart &amp; Vascular Center Harvard Medical School Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subodh","family":"Verma","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery St. Michael's Hospital Toronto Ontario Canada"},{"name":"Li Ka Shing Knowledge Institute of St. Michael's Hospital Toronto Ontario Canada"},{"name":"Department of Surgery University of Toronto Ontario Canada"},{"name":"King Saud University\u2010Li Ka Shing Collaborative Research Program King Saud University Riyadh Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Al\u2010Omran","sequence":"additional","affiliation":[{"name":"Division of Vascular Surgery St. Michael's Hospital Toronto Ontario Canada"},{"name":"Li Ka Shing Knowledge Institute of St. Michael's Hospital Toronto Ontario Canada"},{"name":"Department of Surgery University of Toronto Ontario Canada"},{"name":"King Saud University\u2010Li Ka Shing Collaborative Research Program King Saud University Riyadh Kingdom of Saudi Arabia"},{"name":"Department of Surgery King Saud University Riyadh Kingdom of Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehl445"},{"issue":"23","key":"e_1_3_2_3_2","first-page":"III\u201039","article-title":"Beneficial cardiovascular pleiotropic effects of statins","volume":"109","author":"Davignon J","year":"2004","unstructured":"Davignon J. 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