{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T15:49:44Z","timestamp":1762098584991,"version":"3.41.2"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"18","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,9,18]]},"abstract":"\n Background<\/jats:title>\n \n People living with\n HIV<\/jats:styled-content>\n (\n PHIV<\/jats:styled-content>\n ) are at an increased risk for sudden cardiac death, and implantable cardioverter\u2010defibrillators (\n ICDs<\/jats:styled-content>\n ) prevent\n SCD<\/jats:styled-content>\n . There are no data on the incidence, predictors, and effects of\n ICD<\/jats:styled-content>\n therapies among\n PHIV<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We compared\n ICD<\/jats:styled-content>\n discharge rates between 59\n PHIV<\/jats:styled-content>\n and 267 uninfected controls. For\n PHIV<\/jats:styled-content>\n , we tested the association of traditional cardiovascular risk factors and\n HIV<\/jats:styled-content>\n \u2010specific parameters with an\n ICD<\/jats:styled-content>\n discharge and then tested whether an\n ICD<\/jats:styled-content>\n discharge among\n PHIV<\/jats:styled-content>\n was associated with cardiovascular mortality or an admission for heart failure. The indication for\n ICD<\/jats:styled-content>\n insertion was similar among groups. Compared with controls,\n PHIV<\/jats:styled-content>\n with an\n ICD<\/jats:styled-content>\n were more likely to have coronary artery disease and to use cocaine. In follow\u2010up,\n PHIV<\/jats:styled-content>\n had a higher\n ICD<\/jats:styled-content>\n discharge rate (39% versus 20%;\n P<\/jats:italic>\n =0.001; median follow\u2010up period, 19\u00a0months). Among\n PHIV<\/jats:styled-content>\n , cocaine use, coronary artery disease,\n QRS<\/jats:styled-content>\n duration, and higher New York Heart Association class were associated with an\n ICD<\/jats:styled-content>\n discharge. An\n ICD<\/jats:styled-content>\n discharge had a prognostic effect, with a subsequent 1.7\u2010fold increase in heart failure admission and a 2\u2010fold increase in cardiovascular mortality, an effect consistent across racial\/ethnic and sex categories.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n ICD<\/jats:styled-content>\n discharge rates are higher among\n PHIV<\/jats:styled-content>\n compared with uninfected controls. Among\n PHIV<\/jats:styled-content>\n , cocaine use and New York Heart Association class are associated with increased\n ICD<\/jats:styled-content>\n discharge, and an\n ICD<\/jats:styled-content>\n discharge is associated with a subsequent increase in admission for heart failure and cardiovascular mortality.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.118.009857","type":"journal-article","created":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T15:02:17Z","timestamp":1537110137000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Incidence, Predictors, and Outcomes of Implantable Cardioverter\u2010Defibrillator Discharge Among People Living With HIV"],"prefix":"10.1161","volume":"7","author":[{"given":"Raza M.","family":"Alvi","sequence":"first","affiliation":[{"name":"Cardiac MR PET CT Program Department of Radiology and Division of Cardiology Massachusetts General Hospital Harvard Medical School Boston MA"},{"name":"Bronx\u2010Lebanon Hospital Center of Icahn School of Medicine at Mount Sinai Bronx NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne M.","family":"Neilan","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases Department of Medicine and Department of Pediatrics Massachusetts General Hospital Harvard Medical School Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noor","family":"Tariq","sequence":"additional","affiliation":[{"name":"Yale New Haven Hospital of Yale University School of Medicine New Haven CT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magid","family":"Awadalla","sequence":"additional","affiliation":[{"name":"Cardiac MR PET CT Program Department of Radiology and Division of Cardiology Massachusetts General Hospital Harvard Medical School Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Rokicki","sequence":"additional","affiliation":[{"name":"Cardiac MR PET CT Program Department of Radiology and Division of Cardiology Massachusetts General Hospital Harvard Medical School Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malek","family":"Hassan","sequence":"additional","affiliation":[{"name":"Cardiac MR PET CT Program Department of Radiology and Division of Cardiology Massachusetts General Hospital Harvard Medical School Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Afshar","sequence":"additional","affiliation":[{"name":"Bronx\u2010Lebanon Hospital Center of Icahn School of Medicine at Mount Sinai Bronx NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Connor P.","family":"Mulligan","sequence":"additional","affiliation":[{"name":"Cardiac MR PET CT Program Department of Radiology and Division of Cardiology Massachusetts General Hospital Harvard Medical School Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia A.","family":"Triant","sequence":"additional","affiliation":[{"name":"Divisions of Infectious Diseases and General Internal Medicine Department of Medicine Massachusetts General Hospital Harvard Medical School Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markella V.","family":"Zanni","sequence":"additional","affiliation":[{"name":"Program in Nutritional Metabolism Massachusetts General Hospital Harvard Medical School Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomas G.","family":"Neilan","sequence":"additional","affiliation":[{"name":"Cardiac MR PET CT Program Department of Radiology and Division of Cardiology Massachusetts General Hospital Harvard Medical School Boston MA"},{"name":"Division of Cardiology Massachusetts General Hospital Harvard Medical School Boston MA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.02.024"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.023846"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2018.02.014"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.10.078"},{"key":"e_1_3_1_6_2","first-page":"737","article-title":"Risk of heart failure with human immunodeficiency virus in the absence of prior diagnosis of coronary heart disease","volume":"171","author":"Butt AA","year":"2011","unstructured":"Butt AA, Chang CC, Kuller L, Goetz MB, Leaf D, Rimland D, Gibert CL, Oursler KK, Rodriguez\u2010Barradas MC, Lim J, Kazis LE, Gottlieb S, Justice AC, Freiberg MS. 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