{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T23:09:13Z","timestamp":1781737753129,"version":"3.54.5"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,8,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In randomized controlled trials, perioperative administration of amiodarone has been shown to reduce the incidence of postoperative atrial arrhythmias and length of stay (\n              <jats:styled-content style=\"fixed-case\">LOS<\/jats:styled-content>\n              ) among patients undergoing coronary bypass surgery. However, little is known about the use or effectiveness of perioperative amiodarone in routine clinical practice.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We studied patients \u226518\u00a0years old without a previous history of atrial or ventricular arrhythmias who underwent elective coronary bypass surgery between 2013 and 2014 within a network of 235\n              <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>\n              hospitals. Perioperative amiodarone was defined as receipt of amiodarone either on the day of or the day preceding surgery. We used covariate\u2010adjusted modeling and instrumental variable methods to examine the association between receipt of amiodarone and the development of atrial arrhythmias, in\u2010hospital mortality, readmission,\n              <jats:styled-content style=\"fixed-case\">LOS<\/jats:styled-content>\n              , and cost. Of 12\u00a0758 patients, 2195 (17.2%) received perioperative amiodarone, 3330 (26.1%) developed atrial arrhythmias postoperatively, and the average\n              <jats:styled-content style=\"fixed-case\">LOS<\/jats:styled-content>\n              was 6.4\u00a0days (\u00b12.6\u00a0days). Instrumental variable analysis showed that receipt of perioperative amiodarone was associated with lower risk of atrial arrhythmias (risk difference \u221211 percentage points, 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              \u221219 to \u22124 percentage points;\n              <jats:italic>P<\/jats:italic>\n              =0.002) and a shorter\n              <jats:styled-content style=\"fixed-case\">LOS<\/jats:styled-content>\n              (\u22120.7\u00a0day, 95%\n              <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n              \u22121.39 to \u22120.01\u00a0days;\n              <jats:italic>P<\/jats:italic>\n              =0.048). There was no association between receipt of perioperative amiodarone and in\u2010hospital mortality, cost, or readmission.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Among patients undergoing coronary bypass surgery without previous arrhythmias, perioperative amiodarone is associated with a lower risk of atrial arrhythmias and shorter\n              <jats:styled-content style=\"fixed-case\">LOS<\/jats:styled-content>\n              . These findings are consistent with previous randomized trials and lend support to current guideline recommendations.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.118.009892","type":"journal-article","created":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T09:08:06Z","timestamp":1564996086000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Use and Outcomes Associated With Perioperative Amiodarone in Cardiac Surgery"],"prefix":"10.1161","volume":"8","author":[{"given":"Auras R.","family":"Atreya","sequence":"first","affiliation":[{"name":"Section of Electrophysiology, Samuel and Jean Frankel Cardiovascular Center University of Michigan Ann Arbor MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aruna","family":"Priya","sequence":"additional","affiliation":[{"name":"Institute for Healthcare Delivery and Population Science University of Massachusetts Medical School\u2010Baystate Springfield MA"},{"name":"School of Public Health and Health Sciences University of Massachusetts Amherst MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quinn R.","family":"Pack","sequence":"additional","affiliation":[{"name":"Institute for Healthcare Delivery and Population Science University of Massachusetts Medical School\u2010Baystate Springfield MA"},{"name":"Department of Medicine University of Massachusetts Medical School\u2010Baystate Springfield MA"},{"name":"Division of Cardiology University of Massachusetts Medical School\u2010Baystate Springfield MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penelope S.","family":"Pekow","sequence":"additional","affiliation":[{"name":"Institute for Healthcare Delivery and Population Science University of Massachusetts Medical School\u2010Baystate Springfield MA"},{"name":"School of Public Health and Health Sciences University of Massachusetts Amherst MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela","family":"Stefan","sequence":"additional","affiliation":[{"name":"Institute for Healthcare Delivery and Population Science University of Massachusetts Medical School\u2010Baystate Springfield MA"},{"name":"Department of Medicine University of Massachusetts Medical School\u2010Baystate Springfield MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"Lagu","sequence":"additional","affiliation":[{"name":"Institute for Healthcare Delivery and Population Science University of Massachusetts Medical School\u2010Baystate Springfield MA"},{"name":"Department of Medicine University of Massachusetts Medical School\u2010Baystate Springfield MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir S.","family":"Lotfi","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Massachusetts Medical School\u2010Baystate Springfield MA"},{"name":"Division of Cardiology University of Massachusetts Medical School\u2010Baystate Springfield MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter K.","family":"Lindenauer","sequence":"additional","affiliation":[{"name":"Institute for Healthcare Delivery and Population Science University of Massachusetts Medical School\u2010Baystate Springfield MA"},{"name":"Department of Medicine University of Massachusetts Medical School\u2010Baystate Springfield MA"},{"name":"Department of Quantitative and Population Health Sciences University of Massachusetts Medical School Worcester MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0033-0620(89)90031-5"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0b013e318214876d"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0b013e3280117cc5"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199705153362006"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(93)90894-N"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.4037\/ajcc2002.11.3.228"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.3.390"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199710000-00011"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)00829-8"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)01530-7"},{"key":"e_1_3_1_12_2","first-page":"CD003611","article-title":"Interventions for preventing post\u2010operative atrial fibrillation in patients undergoing heart surgery","volume":"1","author":"Arsenault KA","year":"2013","unstructured":"Arsenault KA, Yusuf AM, Crystal E, Healey JS, Morillo CA, Nair GM, Whitlock RP. Interventions for preventing post\u2010operative atrial fibrillation in patients undergoing heart surgery. Cochrane Database Syst Rev. 2013;1:CD003611.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.4330\/wjc.v8.i10.615"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1413534"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.24.3093"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2006.06.032"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199801000-00004"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.10.004"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3697"},{"key":"e_1_3_1_20_2","unstructured":"Reducing Bias in a Propensity Score Matched\u2010Pair Sample Using Greedy Matching Techniques . 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