{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T20:20:17Z","timestamp":1777494017663,"version":"3.51.4"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"14","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,7,17]]},"abstract":"\n Background<\/jats:title>\n \n Magnesium sulfate (Mg\n SO<\/jats:styled-content>\n 4<\/jats:sub>\n ) has been used as a common therapy for preeclampsia and eclampsia for many years. Mg\n SO<\/jats:styled-content>\n 4<\/jats:sub>\n decreases peripheral vascular resistance so as to reduce maternal blood pressure. Whether placental blood vessels react to Mg\n SO<\/jats:styled-content>\n 4<\/jats:sub>\n in the same patterns as that in maternal vessels is largely unknown.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n This study compared placental vessels (\n PV<\/jats:styled-content>\n ) versus nonplacental vessels (non\u2010\n PV<\/jats:styled-content>\n ) in human and animal models. Mg\n SO<\/jats:styled-content>\n 4<\/jats:sub>\n \u2010caused vascular dilation was significantly weaker in\n PV<\/jats:styled-content>\n than that in non\u2010\n PV<\/jats:styled-content>\n . Prostaglandin I\n 2<\/jats:sub>\n synthetase affected Mg\n SO<\/jats:styled-content>\n 4<\/jats:sub>\n \u2010mediated vasodilatation in\n PV<\/jats:styled-content>\n , not in umbilical vessels, while cyclooxygenase did not influence Mg\n SO<\/jats:styled-content>\n 4<\/jats:sub>\n \u2010induced relaxation in both\n PV<\/jats:styled-content>\n and non\u2010\n PV<\/jats:styled-content>\n . Mg\n 2+<\/jats:sup>\n \u2010caused vasodilatation was mainly through calcium channels. In\n PV<\/jats:styled-content>\n , calcium channel activities were significantly weaker in\n PV<\/jats:styled-content>\n than that in non\u2010\n PV<\/jats:styled-content>\n . Relative\n mRNA<\/jats:styled-content>\n expression of\n \n CACNA<\/jats:styled-content>\n 1D\n <\/jats:italic>\n ,\n \n CACNB<\/jats:styled-content>\n 2\n <\/jats:italic>\n , and\n \n CACNB<\/jats:styled-content>\n 3\n <\/jats:italic>\n was significantly higher in\n PV<\/jats:styled-content>\n than those in umbilical vessels, despite the fact that the expression of\n \n CACNA<\/jats:styled-content>\n 1F\n <\/jats:italic>\n was less in\n PV<\/jats:styled-content>\n . The contractile phenotype of smooth muscle cell marker (\n CALD<\/jats:styled-content>\n 1) was less and the synthetic phenotype (\n MYH<\/jats:styled-content>\n 10) was more in\n PV<\/jats:styled-content>\n than that in\n UV<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n These results demonstrated that\n PV<\/jats:styled-content>\n were characterized by much weaker responses to Mg\n SO<\/jats:styled-content>\n 4<\/jats:sub>\n compared with nonplacental vessels. The difference was related to weaker calcium channel activity and minor contractile phenotype smooth muscle cells in\n PV<\/jats:styled-content>\n , providing important information for further understanding treatments with Mg\n SO<\/jats:styled-content>\n 4<\/jats:sub>\n in preeclampsia.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.118.009896","type":"journal-article","created":{"date-parts":[[2018,7,12]],"date-time":"2018-07-12T09:15:49Z","timestamp":1531386949000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":21,"title":["Magnesium Sulfate\u2013Mediated Vascular Relaxation and Calcium Channel Activity in Placental Vessels Different From Nonplacental Vessels"],"prefix":"10.1161","volume":"7","author":[{"given":"Jiaqi","family":"Tang","sequence":"first","affiliation":[{"name":"Institute of Fetology First Hospital of Soochow University Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axin","family":"He","sequence":"additional","affiliation":[{"name":"Institute of Fetology First Hospital of Soochow University Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Fetology First Hospital of Soochow University Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueyi","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Fetology First Hospital of Soochow University Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuwen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Fetology First Hospital of Soochow University Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaorong","family":"Fan","sequence":"additional","affiliation":[{"name":"Institute of Fetology First Hospital of Soochow University Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanping","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Fetology First Hospital of Soochow University Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengshu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Fetology First Hospital of Soochow University Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linglu","family":"Qi","sequence":"additional","affiliation":[{"name":"Institute of Fetology First Hospital of Soochow University Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianying","family":"Tao","sequence":"additional","affiliation":[{"name":"Institute of Fetology First Hospital of Soochow University Suzhou China"},{"name":"Obstetrics and Gynecology Department Suzhou Municipal Hospital Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao","family":"Sun","sequence":"additional","affiliation":[{"name":"Institute of Fetology First Hospital of Soochow University Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhice","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Fetology First Hospital of Soochow University Suzhou China"},{"name":"Center for Perinatal Biology Loma Linda University Loma Linda CA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2015.06.056"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2014.11.008"},{"key":"e_1_3_1_4_2","first-page":"128","article-title":"Magnesium and pregnancy","volume":"6","author":"Valenzuela GJ","year":"1987","unstructured":"Valenzuela GJ, Munson LA. 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