{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:58:03Z","timestamp":1790384283465,"version":"4.1.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,10,16]]},"abstract":"\n Background<\/jats:title>\n \n The likelihoods of valvular heart disease (\n VHD<\/jats:styled-content>\n ) and conduction abnormalities in patients with ankylosing spondylitis (\n AS<\/jats:styled-content>\n p) are poorly defined. Knowing their lifetime risks of\n VHD<\/jats:styled-content>\n and pacemaker use would help inform whether cardiac screening should be done.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Patients with\n AS<\/jats:styled-content>\n p and a comparison group without\n AS<\/jats:styled-content>\n p were identified among US Medicare beneficiaries in 1999 to 2013. Frequencies of\n VHD<\/jats:styled-content>\n and pacemaker use were compared in 4 age groups: 65 to 69 years, 70 to 74 years, 75 to 79 years, and 80 years or older, as were rates of valve surgeries, a measure of\n VHD<\/jats:styled-content>\n severity, and new pacemaker insertions. Outcomes were compared between 42\u00a0327 patients with\n AS<\/jats:styled-content>\n p and 19\u00a0211\u00a0703 patients without\n AS<\/jats:styled-content>\n p. The prevalence of aortic valve disease in patients with\n AS<\/jats:styled-content>\n p increased with age (2.6%, 6.7%, 10.9%, and 17.1%), as did the prevalence of mitral valve disease. Risks of\n VHD<\/jats:styled-content>\n were slightly but significantly higher in patients with\n AS<\/jats:styled-content>\n p (adjusted odds ratios 1.06\u20131.51). Rates of aortic valve replacement\/repair were also higher in patients with\n AS<\/jats:styled-content>\n p than in the comparison group (125 versus 93; 183 versus 149; 261 versus 208; 279 versus 191 per 100\u00a0000 patient\u2010years in the 4 age groups). Rates of mitral valve surgery did not differ between groups. Among patients with\n AS<\/jats:styled-content>\n p, pacemaker use ranged from 1.0% to 7.6% across age groups, and was slightly higher than in controls (odds ratio range 1.11\u20131.32).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Lifetime risks of\n VHD<\/jats:styled-content>\n and pacemaker use in\n AS<\/jats:styled-content>\n p increase markedly with age, but are only slightly higher than in elderly people without\n AS<\/jats:styled-content>\n p.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.118.010016","type":"journal-article","created":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T09:01:05Z","timestamp":1539248465000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Lifetime Risks of Valvular Heart Disease and Pacemaker Use in Patients With Ankylosing Spondylitis"],"prefix":"10.1161","volume":"7","author":[{"given":"Michael M.","family":"Ward","sequence":"first","affiliation":[{"name":"Intramural Research Program National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institutes of Health Bethesda MD"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.51.6.705"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-127-8_Part_1-199710150-00007"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(88)90497-4"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1983.tb00188.x"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(98)00393-3"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.4250\/jcu.2012.20.1.30"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2015.04.032"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(82)91946-4"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.1982.tb02416.x"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.51.5.652"},{"key":"e_1_3_1_12_2","first-page":"120","article-title":"Transthoracic and transesophageal echocardiographic evaluation of the aortic root and subvalvular structures in ankylosing spondylitis","volume":"23","author":"Arnason JA","year":"1996","unstructured":"Arnason JA, Patel AK, Rahko PS, Sundstrom WR. 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