{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:22:52Z","timestamp":1790630572094,"version":"4.1.0"},"reference-count":56,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,11,6]]},"abstract":"\n Background<\/jats:title>\n \n Orthostatic hypotension is a prevalent condition in older adults and is associated with impaired physical performance and falls. The ability of older adults to compensate for rapid changes in systolic blood pressure (\n SBP<\/jats:styled-content>\n ; ie,\n SBP<\/jats:styled-content>\n decline rate and\n SBP<\/jats:styled-content>\n variability) may be important for physical performance. This study investigates the association of rapid\n SBP<\/jats:styled-content>\n changes after standing up with physical performance.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Consecutive patients who visited the Center of Geriatrics Amsterdam in 2014 and 2015 were included. The following\n SBP<\/jats:styled-content>\n parameters were computed in 2 intervals (0\u201315 and 15\u2013180\u00a0seconds) after standing up: steepness of steepest\n SBP<\/jats:styled-content>\n decline; ratio of standing\/supine\n SBP<\/jats:styled-content>\n variability; and magnitude of largest\n SBP<\/jats:styled-content>\n decline. Physical performance was assessed using the following measures: chair stand time, timed up and go time, walking speed, handgrip strength, and tandem stance performance. A total of 109 patients (45% men; age, mean, 81.7\u00a0years [\n standard deviation<\/jats:styled-content>\n , 7.0 years]) were included. Steepness of steepest\n SBP<\/jats:styled-content>\n decline (0\u201315\u00a0seconds) was associated with slower chair stand time (\n P<\/jats:italic>\n <0.001), timed up and go time (\n P<\/jats:italic>\n =0.022), and walking speed (\n P<\/jats:italic>\n =0.024). Ratio of standing\/supine\n SBP<\/jats:styled-content>\n variability (0\u201315\u00a0seconds) was associated with slower chair stand time (\n P<\/jats:italic>\n =0.005). Magnitude of largest\n SBP<\/jats:styled-content>\n decline was not associated with physical performance.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n SBP<\/jats:styled-content>\n parameters reflecting rapid SBP changes were more strongly associated with physical performance compared with\n SBP<\/jats:styled-content>\n decline magnitude in geriatric outpatients. These results support the hypothesis of an inadequate cerebral autoregulation during rapid\n SBP<\/jats:styled-content>\n changes and advocate the use of continuous\n blood pressure<\/jats:styled-content>\n measurements.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.118.010060","type":"journal-article","created":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T05:00:25Z","timestamp":1540530025000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":27,"title":["Rapid Systolic Blood Pressure Changes After Standing Up Associate With Impaired Physical Performance in Geriatric Outpatients"],"prefix":"10.1161","volume":"7","author":[{"given":"Arjen","family":"Mol","sequence":"first","affiliation":[{"name":"Department of Human Movement Sciences @AgeAmsterdam Amsterdam Movement Sciences Vrije Universiteit Amsterdam Amsterdam the Netherlands"},{"name":"Department of Biophysics Donders Institute for Brain, Cognition and Behaviour Radboud University Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esmee M.","family":"Reijnierse","sequence":"additional","affiliation":[{"name":"Department of Medicine and Aged Care @AgeMelbourne The Royal Melbourne Hospital The University of Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marijke C.","family":"Trappenburg","sequence":"additional","affiliation":[{"name":"Section\u00a0of Gerontology and Geriatrics Department of Internal Medicine VU University Medical Center Amsterdam Amsterdam the Netherlands"},{"name":"Department of Internal Medicine Amstelland Hospital Amstelveen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J. 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