{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T01:15:38Z","timestamp":1788570938718,"version":"build-2803163510"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,10,16]]},"abstract":"\n Background<\/jats:title>\n \n Multiple percutaneous coronary interventions (\n PCIs<\/jats:styled-content>\n ) are considered determinant of poor outcome in patients undergoing coronary artery bypass grafting (\n CABG<\/jats:styled-content>\n ), but scarce data exist to substantiate this.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Patients who underwent\n CABG<\/jats:styled-content>\n without history of prior\n PCI<\/jats:styled-content>\n or with\n PCI<\/jats:styled-content>\n performed >30\u00a0days before surgery were selected for the present analysis from the prospective, multicenter E\u2010CABG (European Multicenter Study on Coronary Artery Bypass Grafting) registry. Out of 6563 patients with data on preoperative\n SYNTAX<\/jats:styled-content>\n (Synergy between PCI With Taxus and Cardiac Surgery) score, 1181 patients (18.0%) had undergone\n PCI<\/jats:styled-content>\n >30\u00a0days before\n CABG<\/jats:styled-content>\n . Of these, 11.6% underwent a single\n PCI<\/jats:styled-content>\n , 4.4% 2\n PCI<\/jats:styled-content>\n s, and 2.1% \u22653\n PCI<\/jats:styled-content>\n s.\n PCI<\/jats:styled-content>\n of a single main coronary vessel was performed in 11.3%, of 2 main vessels in 4.9%, and of 3 main vessels in 1.6% of patients. Multivariable analysis showed that differences in early mortality and other outcomes were not significantly different in the study cohorts. The adjusted hospital\/30\u2010day mortality rate was 1.8% in patients without history of prior\n PCI<\/jats:styled-content>\n , 1.9% in those with a history of 1\n PCI<\/jats:styled-content>\n , 1.4% after 2\n PCI<\/jats:styled-content>\n s, and 2.5% after \u22653\n PCI<\/jats:styled-content>\n s (adjusted\n P<\/jats:italic>\n =0.8). The adjusted hospital\/30\u2010day mortality rate was 2.0% in those who had undergone\n PCI<\/jats:styled-content>\n of 1 main coronary vessel, 1.3% after\n PCI<\/jats:styled-content>\n of 2 main vessels, and 3.1% after\n PCI<\/jats:styled-content>\n of 3 main coronary vessels (adjusted\n P<\/jats:italic>\n =0.6).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Multiple prior\n PCI<\/jats:styled-content>\n s are not associated with increased risk of early adverse events in patients undergoing isolated\n CABG<\/jats:styled-content>\n . The present results are conditional to survival after\n PCI<\/jats:styled-content>\n and should not be viewed as a support for a policy of multiple\n PCI<\/jats:styled-content>\n as opposed to earlier\n CABG<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Clinical Trial Registration<\/jats:title>\n \n URL<\/jats:styled-content>\n :\n http:\/\/www.Clinicaltrials.gov<\/jats:ext-link>\n . Unique identifier:\n NCT<\/jats:styled-content>\n 02319083.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.118.010089","type":"journal-article","created":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T05:00:27Z","timestamp":1539666027000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Prognostic Impact of Multiple Prior Percutaneous Coronary Interventions in Patients Undergoing Coronary Artery Bypass Grafting"],"prefix":"10.1161","volume":"7","author":[{"given":"Fausto","family":"Biancari","sequence":"first","affiliation":[{"name":"Department of Surgery Oulu University Hospital and University of Oulu Finland"},{"name":"Heart Center Turku University Hospital and University of Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Dal\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Surgery Department of Cardiac Surgery Karolinska Institutet Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vito G.","family":"Ruggieri","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic and Vascular Surgery Robert Debr\u00e9 University Hospital Reims France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Till","family":"Demal","sequence":"additional","affiliation":[{"name":"Hamburg University Heart Center Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Gatti","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery Ospedali Riuniti Trieste Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Onorati","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery Verona University Hospital Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Faggian","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery Verona University Hospital Verona Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino S.","family":"Rubino","sequence":"additional","affiliation":[{"name":"Centro Clinico\u2010Diagnostico \u201cG.B. Morgagni,\u201d Centro Cuore Pedara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Maselli","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery St. Anna Hospital Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Gherli","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Unit Department of Cardiovascular Sciences S. Camillo\u2010Forlanini Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Salsano","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery University of Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Saccocci","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery Centro Cardiologico \u2010 Fondazione Monzino IRCCS University of Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Santarpino","sequence":"additional","affiliation":[{"name":"Cardiovascular Center Paracelsus Medical University Nuremberg Germany"},{"name":"Citt\u00e0 di Lecce Hospital GVM Care & Research Lecce Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Nicolini","sequence":"additional","affiliation":[{"name":"Division of Cardiac Surgery University of Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuomas","family":"Tauriainen","sequence":"additional","affiliation":[{"name":"Department of Surgery Oulu University Hospital and University of Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"De Feo","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Respiratory Sciences University of Campania Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juhani","family":"Airaksinen","sequence":"additional","affiliation":[{"name":"Heart Center Turku University Hospital and University of Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Rosato","sequence":"additional","affiliation":[{"name":"National Center of Global Health Istituto Superiore di Sanit\u00e0 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Perrotti","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardio\u2010Vascular Surgery University Hospital Jean Minjoz Besan\u00e7on France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Mariscalco","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Sciences Clinical Sciences Wing Glenfield Hospital University of Leicester United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","first-page":"1419","article-title":"The Society of Thoracic Surgeons 2018 adult cardiac surgery risk models: part 2\u2014statistical methods and results","volume":"105","author":"O'Brien SM","year":"2018","unstructured":"O'Brien SM, Feng L, He X, Xian Y, Jacobs JP, Badhwar V, Kurlansky PA, Furnary AP, Cleveland JC Jr, Lobdell KW, Vassileva C, Wyler von Ballmoos MC, Thourani VH, Rankin JS, Edgerton JR, D'Agostino RS, Desai ND, Edwards FH, Shahian DM. 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