{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T18:59:53Z","timestamp":1790449193755,"version":"4.1.0"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,10,16]]},"abstract":"\n Background<\/jats:title>\n \n The incidence of cancer treatment\u2013induced arrhythmia (\n CTIA<\/jats:styled-content>\n ) associated with novel, targeted chemotherapeutic agents (\n TCA<\/jats:styled-content>\n s) has not been well described.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n We identified all patients treated at our institution from January 2010 to December 2015 with selected\n TCA<\/jats:styled-content>\n s. We defined\n CTIA<\/jats:styled-content>\n as any new arrhythmia diagnosis code within 6\u00a0months after treatment initiation. As a comparison, we also identified patients treated with anthracycline chemotherapy during the same period. We identified 5026 patients, of whom 2951 (58.7%) received\n TCA<\/jats:styled-content>\n s and 2075 (41.3%) received anthracycline chemotherapy. In the overall cohort, 601 patients (12.0%) developed\n CTIA<\/jats:styled-content>\n . Patients with\n CTIA<\/jats:styled-content>\n were significantly older and more likely to have hypertension, diabetes mellitus, congestive heart failure, coronary disease, and sleep apnea. The incidence of\n CTIA<\/jats:styled-content>\n at 6\u00a0months was significantly lower in the\n TCA<\/jats:styled-content>\n group (9.3% versus 15.8%;\n P<\/jats:italic>\n <0.001). In multivariate analysis, a history of hypertension (hazard ratio, 1.63; 95% confidence interval, 1.34\u20131.98), congestive heart failure (hazard ratio, 2.12; 95% confidence interval, 1.78\u20132.68), and male sex (hazard ratio, 1.25; 95% confidence interval, 1.06\u20131.47) were associated with a significantly increased risk of\n CTIA<\/jats:styled-content>\n , whereas treatment with\n TCA<\/jats:styled-content>\n s, compared with anthracycline chemotherapy, was associated with a significantly lower risk (hazard ratio, 0.60; 95% confidence interval, 0.51\u20130.71).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Compared with anthracyclines, treatment with TCAs was associated with an \u224840% reduced risk of new\u2010onset arrhythmia diagnoses during the first 6\u00a0months of treatment.<\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.118.010101","type":"journal-article","created":{"date-parts":[[2018,10,13]],"date-time":"2018-10-13T09:00:43Z","timestamp":1539421243000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Incidence of Cancer Treatment\u2013Induced Arrhythmia Associated With Novel Targeted Chemotherapeutic Agents"],"prefix":"10.1161","volume":"7","author":[{"given":"Andrew C.","family":"Nickel","sequence":"first","affiliation":[{"name":"Emory University School of Medicine Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akshar","family":"Patel","sequence":"additional","affiliation":[{"name":"Section\u00a0of Cardiac Electrophysiology Cardiology Division Emory University School of Medicine Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabil F.","family":"Saba","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine Atlanta GA"},{"name":"Department of Hematology and Medical Oncology Winship Cancer Institute Emory University Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel R.","family":"Leon","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine Atlanta GA"},{"name":"Section\u00a0of Cardiac Electrophysiology Cardiology Division Emory University School of Medicine Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhael F.","family":"El\u2010Chami","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine Atlanta GA"},{"name":"Section\u00a0of Cardiac Electrophysiology Cardiology Division Emory University School of Medicine Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal M.","family":"Merchant","sequence":"additional","affiliation":[{"name":"Emory University School of Medicine Atlanta GA"},{"name":"Section\u00a0of Cardiac Electrophysiology Cardiology 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GA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1100265"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61865-0"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2016.09.010"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.117.005443"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-016-6711-0"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-10-604272"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28040"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2013.04.027"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-014-3029-0"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2016.02.024"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1609214"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2016.07.049"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.smj.0000257382.89910.fe"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.09.002"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002192"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.006028"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.04.062"}],"container-title":["Journal of the American Heart 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