{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:29:55Z","timestamp":1790728195608,"version":"4.1.0"},"reference-count":59,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2019,7,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The incidence of type 1 diabetes mellitus (T1DM) in children is increasing, resulting in higher burden of cardiovascular diseases due to diabetes mellitus\u2013related vascular dysfunction.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods and Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              We examined cardiovascular risk factors (\n              <jats:styled-content style=\"fixed-case\">CVRF<\/jats:styled-content>\n              s) and arterial parameters in 1809 youth with T1DM. Demographics, anthropometrics, blood pressure, and laboratory data were collected at T1DM onset and 5\u00a0years later. Pulse wave velocity and augmentation index were collected with tonometry.\n              <jats:styled-content style=\"fixed-case\">ANOVA<\/jats:styled-content>\n              or chi\u2010square tests were used to test for differences in measures of arterial parameters by\n              <jats:styled-content style=\"fixed-case\">CVRF<\/jats:styled-content>\n              . Area under the curve of\n              <jats:styled-content style=\"fixed-case\">CVRF<\/jats:styled-content>\n              s was entered in general linear models to explore determinants of accelerate vascular aging. Participants at the time of arterial measurement were 17.6\u00b14.5\u00a0years old, 50% female, 76% non\u2010Hispanic white, and duration of T1DM was 7.8\u00b11.9\u00a0years. Glycemic control was poor (glycated hemoglobin, 9.1\u00b11.8%). All arterial parameters were higher in participants with glycated hemoglobin \u22659% and pulse wave velocity was higher with lower insulin sensitivity or longer duration of diabetes mellitus. Differences in arterial parameters were found by sex, age, and presence of obesity, hypertension, or dyslipidemia. In multivariable models, higher glycated hemoglobin, lower insulin sensitivity, body mass index, blood pressure, and lipid areas under the curve were associated with accelerated vascular aging.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              In young people with T1DM, persistent poor glycemic control and higher levels of traditional\n              <jats:styled-content style=\"fixed-case\">CVRF<\/jats:styled-content>\n              s are independently associated with arterial aging. Improving glycemic control and interventions to lower\n              <jats:styled-content style=\"fixed-case\">CVRF<\/jats:styled-content>\n              s may prevent future cardiovascular events in young individuals with T1DM.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.118.010150","type":"journal-article","created":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T09:02:09Z","timestamp":1560934929000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":65,"title":["Burden of Cardiovascular Risk Factors Over Time and Arterial Stiffness in Youth With Type 1 Diabetes Mellitus: The SEARCH for\u00a0Diabetes in Youth Study"],"prefix":"10.1161","volume":"8","author":[{"given":"Elaine M.","family":"Urbina","sequence":"first","affiliation":[{"name":"Heart Institute Cincinnati Children's Hospital &amp; University of Cincinnati OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Isom","sequence":"additional","affiliation":[{"name":"Department of Biostatistical Sciences Wake Forest School of Medicine Winston\u2010Salem NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronny A.","family":"Bell","sequence":"additional","affiliation":[{"name":"Department of Public Health East Carolina University Greenville NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah A.","family":"Bowlby","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology &amp; Diabetes Medical University of South Carolina Charleston SC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Ralph","family":"D'Agostino","sequence":"additional","affiliation":[{"name":"Department of Biostatistical Sciences Wake Forest School of Medicine Winston\u2010Salem NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen R.","family":"Daniels","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Colorado School of Medicine Aurora CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence M.","family":"Dolan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Cincinnati Children's Hospital &amp; University of Cincinnati OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina","family":"Imperatore","sequence":"additional","affiliation":[{"name":"Division of Diabetes Translation Centers for Disease Control and Prevention Atlanta GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santica M.","family":"Marcovina","sequence":"additional","affiliation":[{"name":"Northwest Lipid Metabolism and Diabetes Research Laboratory University of Washington Seattle WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anwar T.","family":"Merchant","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology &amp; Diabetes Medical University of South Carolina Charleston SC USA"},{"name":"Department of Epidemiology and Biostatistics University of South Carolina Columbia SC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristi","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Department of Research &amp; Evaluation Kaiser Permanente Southern California Pasadena CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy S.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Cincinnati Children's Hospital &amp; University of Cincinnati OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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