{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T05:46:49Z","timestamp":1784958409587,"version":"3.55.0"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2018,10,16]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Antazoline mesylate represents an antihistamine capable of rapid and safe cardioversion of atrial fibrillation, yet evidence concerning its efficacy in comparison to other medications is insufficient. The study aimed to evaluate the success rate and safety of pharmacological cardioversion of atrial fibrillation with intravenous antazoline (\n                      <jats:styled-content style=\"fixed-case\">CANT<\/jats:styled-content>\n                      [Cardioversion With Antazoline Mesylate] study) in the setting of the emergency department.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      After reviewing 1984 medical records, 450 eligible patients (22.7%) with short\u2010duration atrial fibrillation subject to pharmacological cardioversion were enrolled in a retrospective observational analysis. The choice of antiarrhythmic drug was left to the discretion of the attending physician. The primary end point was successful cardioversion in the emergency department. The safety end point comprised bradycardia &lt;45\u00a0bpm, hypotension, syncope, or death. The study population (mean age, 65.5\u00b111.9\u00a0years; 52.9% females) was characterized by a median atrial fibrillation episode duration of 10\u00a0hours. Antazoline, alone or in combination, was administered in 24.2% (n=109) and 40% (n=180), respectively; amiodarone was administered in 46.7% and propafenone in 9.3%, while \u22652 antiarrhythmic drugs were administered in 19.8% of patients. Antazoline had the highest success rate of pharmacological cardioversion among all drugs (85.3%), which was comparable with propafenone (78.6%; relative risk, 1.09, 95% confidence interval, 0.91\u20131.30;\n                      <jats:italic>P<\/jats:italic>\n                      =0.317) and higher than amiodarone treatment (66.7%; relative risk, 1.28, 95% confidence interval, 1.13\u20131.45;\n                      <jats:italic>P<\/jats:italic>\n                      &lt;0.001; number needed to treat, 5.4). The rate of cardioversion with antazoline alone was higher than combined amiodarone and\/or propafenone (68.1%; relative risk, 1.25; 95% confidence interval, 1.12\u20131.40,\n                      <jats:italic>P<\/jats:italic>\n                      =0.0001). No safety end points were reported in the antazoline group, while 5 incidents occurred in the non\u2010antazoline cohort (\n                      <jats:italic>P<\/jats:italic>\n                      =0.075).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Antazoline represents an efficacious and safe method of pharmacological cardioversion in a real\u2010life setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.118.010153","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T05:02:57Z","timestamp":1539061377000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Pharmacological Cardioversion With Antazoline in Atrial Fibrillation: The Results of the CANT Study"],"prefix":"10.1161","volume":"7","author":[{"given":"Maciej T.","family":"Wybraniec","sequence":"first","affiliation":[{"name":"First Department of Cardiology School of Medicine in Katowice Medical University of Silesia Katowice Poland"},{"name":"Upper Silesia Medical Center Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Wr\u00f3bel","sequence":"additional","affiliation":[{"name":"First Department of Cardiology School of Medicine in Katowice Medical University of Silesia Katowice Poland"},{"name":"Upper Silesia Medical Center Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Wilkosz","sequence":"additional","affiliation":[{"name":"First Department of Cardiology School of Medicine in Katowice Medical University of Silesia Katowice Poland"},{"name":"Upper Silesia Medical Center Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Wrona","sequence":"additional","affiliation":[{"name":"First Department of Cardiology School of Medicine in Katowice Medical University of Silesia Katowice Poland"},{"name":"Upper Silesia Medical Center Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Bula","sequence":"additional","affiliation":[{"name":"First Department of Cardiology School of Medicine in Katowice Medical University of Silesia Katowice Poland"},{"name":"Upper Silesia Medical Center Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Mizia\u2010Stec","sequence":"additional","affiliation":[{"name":"First Department of Cardiology School of Medicine in Katowice Medical University of Silesia Katowice Poland"},{"name":"Upper Silesia Medical Center Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61774-8"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/acem.12016"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/MEJ.0000000000000198"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw210"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000040"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-013-0586-x"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2007.01.059"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.3109\/14017431.2012.740572"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.07.046"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.2174\/1573403X10666140513103709"},{"key":"e_1_3_1_12_2","first-page":"639","article-title":"A new synthetic anti\u2010histaminic substance, antistine","volume":"26","author":"Heinberg CJ","year":"1947","unstructured":"Heinberg CJ. 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